ENSG00000166833

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000349880 ENSG00000166833 HEK293_OSMI2_2hA HEK293_TMG_2hB NAV2 protein_coding protein_coding 0.8466418 1.180745 0.7482679 0.2010025 0.2018989 -0.6510854 0.15377046 0.02699042 0.17437013 0.02699042 0.09019553 2.3173816 0.23414167 0.01813333 0.24240000 0.22426667 0.28923681 0.01652179 FALSE TRUE
ENST00000360655 ENSG00000166833 HEK293_OSMI2_2hA HEK293_TMG_2hB NAV2 protein_coding protein_coding 0.8466418 1.180745 0.7482679 0.2010025 0.2018989 -0.6510854 0.09491618 0.05650401 0.10793117 0.02936239 0.05650811 0.8264319 0.12472917 0.05983333 0.15870000 0.09886667 0.71440010 0.01652179 FALSE TRUE
ENST00000528923 ENSG00000166833 HEK293_OSMI2_2hA HEK293_TMG_2hB NAV2 protein_coding retained_intron 0.8466418 1.180745 0.7482679 0.2010025 0.2018989 -0.6510854 0.30079621 0.66933288 0.04598346 0.15276598 0.04598346 -3.6010461 0.27937500 0.55840000 0.08153333 -0.47686667 0.01652179 0.01652179   FALSE
ENST00000533917 ENSG00000166833 HEK293_OSMI2_2hA HEK293_TMG_2hB NAV2 protein_coding protein_coding 0.8466418 1.180745 0.7482679 0.2010025 0.2018989 -0.6510854 0.16245606 0.31146128 0.15091026 0.01935319 0.05054145 -0.9983887 0.20924583 0.27630000 0.23793333 -0.03836667 0.82767688 0.01652179 FALSE TRUE
ENST00000650578 ENSG00000166833 HEK293_OSMI2_2hA HEK293_TMG_2hB NAV2 protein_coding protein_coding 0.8466418 1.180745 0.7482679 0.2010025 0.2018989 -0.6510854 0.02663336 0.00000000 0.21306684 0.00000000 0.21306684 4.4794042 0.02312917 0.00000000 0.18503333 0.18503333 0.70279293 0.01652179   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000166833 E001 0.3289534 0.028515114 8.146987e-01   11 19350724 19351027 304 + 0.140 0.107 -0.445
ENSG00000166833 E002 1.8673450 0.120523819 4.955688e-01 6.323519e-01 11 19712837 19713596 760 + 0.515 0.384 -0.679
ENSG00000166833 E003 1.6480899 0.015065612 2.614498e-01 3.990917e-01 11 19713597 19713962 366 + 0.516 0.326 -1.028
ENSG00000166833 E004 0.0000000       11 19777802 19777982 181 +      
ENSG00000166833 E005 0.1472490 0.042829338 3.615533e-01   11 19813718 19813855 138 + 0.140 0.000 -12.565
ENSG00000166833 E006 1.3942657 0.025433189 3.414695e-02 8.004550e-02 11 19832484 19832601 118 + 0.563 0.193 -2.252
ENSG00000166833 E007 0.8126314 0.015378759 8.616624e-02 1.692634e-01 11 19842871 19842923 53 + 0.401 0.107 -2.444
ENSG00000166833 E008 0.8470867 0.014316586 4.244445e-01 5.674206e-01 11 19868925 19868997 73 + 0.330 0.193 -1.029
ENSG00000166833 E009 2.1014903 0.007159428 1.620298e-01 2.777622e-01 11 19879869 19880127 259 + 0.606 0.379 -1.123
ENSG00000166833 E010 0.0000000       11 19884294 19884362 69 +      
ENSG00000166833 E011 0.7792333 0.017112757 8.652039e-02 1.698341e-01 11 19892434 19892594 161 + 0.401 0.107 -2.445
ENSG00000166833 E012 0.0000000       11 19931765 19931790 26 +      
ENSG00000166833 E013 6.4659033 0.133928874 6.320584e-02 1.320470e-01 11 19933176 19934277 1102 + 1.050 0.705 -1.327
ENSG00000166833 E014 2.1724417 0.027254703 1.324289e-03 5.057507e-03 11 19939661 19939773 113 + 0.745 0.193 -3.027
ENSG00000166833 E015 2.2572470 0.006879631 5.794347e-03 1.807276e-02 11 19946401 19946509 109 + 0.714 0.264 -2.319
ENSG00000166833 E016 4.6888485 0.003615506 1.145317e-02 3.224168e-02 11 19948691 19949080 390 + 0.915 0.579 -1.371
ENSG00000166833 E017 2.9163117 0.005589962 3.715346e-02 8.576769e-02 11 19984125 19984247 123 + 0.745 0.427 -1.445
ENSG00000166833 E018 0.0000000       11 20022556 20022795 240 +      
ENSG00000166833 E019 0.0000000       11 20022838 20022844 7 +      
ENSG00000166833 E020 0.0000000       11 20022845 20022902 58 +      
ENSG00000166833 E021 0.0000000       11 20022903 20023089 187 +      
ENSG00000166833 E022 0.1451727 0.044928453 3.608410e-01   11 20023090 20023132 43 + 0.140 0.000 -12.560
ENSG00000166833 E023 0.0000000       11 20027255 20027467 213 +      
ENSG00000166833 E024 0.0000000       11 20027554 20027701 148 +      
ENSG00000166833 E025 2.2070108 0.007206552 5.740858e-03 1.793043e-02 11 20035959 20036097 139 + 0.714 0.264 -2.319
ENSG00000166833 E026 4.8048659 0.003560469 6.665864e-05 3.639588e-04 11 20043981 20044272 292 + 1.005 0.470 -2.223
ENSG00000166833 E027 8.0692006 0.013975985 4.401736e-01 5.818580e-01 11 20044968 20045670 703 + 1.005 0.915 -0.334
ENSG00000166833 E028 6.1809531 0.002899004 1.910398e-01 3.150548e-01 11 20048728 20049195 468 + 0.934 0.780 -0.597
ENSG00000166833 E029 1.1823698 0.011468219 4.289327e-01 5.716658e-01 11 20049836 20049901 66 + 0.401 0.264 -0.859
ENSG00000166833 E030 2.2476925 0.007136524 7.682524e-01 8.502776e-01 11 20051289 20051333 45 + 0.516 0.471 -0.221
ENSG00000166833 E031 4.1966221 0.004074359 5.520908e-01 6.814478e-01 11 20054080 20054240 161 + 0.745 0.665 -0.329
ENSG00000166833 E032 5.2587227 0.003248137 9.899849e-01 9.978382e-01 11 20055769 20055957 189 + 0.774 0.780 0.025
ENSG00000166833 E033 0.4031496 0.023911848 3.000075e-01 4.416311e-01 11 20056530 20056628 99 + 0.000 0.193 11.913
ENSG00000166833 E034 3.4247612 0.008248727 1.593202e-01 2.742138e-01 11 20062307 20062359 53 + 0.462 0.691 1.044
ENSG00000166833 E035 2.7625019 0.005615357 3.763651e-01 5.206979e-01 11 20068186 20068209 24 + 0.462 0.609 0.693
ENSG00000166833 E036 3.3859653 0.004801799 2.689330e-01 4.073993e-01 11 20068324 20068398 75 + 0.516 0.691 0.777
ENSG00000166833 E037 2.7186215 0.006108006 3.800369e-01 5.242999e-01 11 20077552 20077635 84 + 0.462 0.609 0.692
ENSG00000166833 E038 3.4184592 0.005514752 5.258943e-01 6.592148e-01 11 20077993 20078104 112 + 0.563 0.665 0.449
ENSG00000166833 E039 4.6687086 0.067684693 7.449377e-01 8.331044e-01 11 20080064 20080209 146 + 0.681 0.764 0.340
ENSG00000166833 E040 0.5149242 0.145106917 8.016093e-01 8.735862e-01 11 20082592 20082600 9 + 0.140 0.193 0.558
ENSG00000166833 E041 5.0875413 0.003439400 4.793550e-01 6.177333e-01 11 20083007 20083179 173 + 0.826 0.737 -0.352
ENSG00000166833 E042 3.0739532 0.034248748 6.739410e-01 7.795102e-01 11 20090865 20091018 154 + 0.645 0.577 -0.300
ENSG00000166833 E043 5.2098102 0.007793575 8.519615e-01 9.082249e-01 11 20092206 20092368 163 + 0.801 0.779 -0.085
ENSG00000166833 E044 5.9097366 0.003010256 3.397390e-01 4.836670e-01 11 20093099 20093199 101 + 0.894 0.780 -0.445
ENSG00000166833 E045 6.1646816 0.002812057 1.438789e-01 2.532912e-01 11 20095672 20095767 96 + 0.934 0.759 -0.679
ENSG00000166833 E046 7.2469683 0.051856432 7.020216e-01 8.009387e-01 11 20097577 20097745 169 + 0.935 0.874 -0.232
ENSG00000166833 E047 7.5298261 0.002700943 2.224789e-01 3.533413e-01 11 20100937 20101172 236 + 0.988 0.854 -0.508
ENSG00000166833 E048 7.1201168 0.053975203 7.934383e-01 8.679269e-01 11 20103255 20103409 155 + 0.915 0.875 -0.153
ENSG00000166833 E049 5.0509925 0.003408541 4.053321e-01 5.490232e-01 11 20103653 20103724 72 + 0.681 0.800 0.482
ENSG00000166833 E050 0.1817044 0.039008943 6.485015e-01   11 20104211 20105530 1320 + 0.000 0.107 10.981
ENSG00000166833 E051 6.0567952 0.010177007 8.543334e-01 9.098881e-01 11 20105531 20105727 197 + 0.826 0.853 0.104
ENSG00000166833 E052 0.0000000       11 20107245 20107663 419 +      
ENSG00000166833 E053 4.6561762 0.040863324 9.628458e-01 9.805205e-01 11 20107664 20107782 119 + 0.745 0.755 0.041
ENSG00000166833 E054 0.1482932 0.043939845 6.478281e-01   11 20114383 20114591 209 + 0.000 0.107 10.971
ENSG00000166833 E055 6.9172051 0.002565785 4.753140e-01 6.140211e-01 11 20114592 20114795 204 + 0.826 0.917 0.348
ENSG00000166833 E056 88.5922952 0.003348233 1.656542e-12 3.913541e-11 11 20118133 20121601 3469 + 1.737 2.017 0.945