ENSG00000166813

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000394412 ENSG00000166813 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF7 protein_coding protein_coding 23.81287 37.3928 16.84972 2.517807 0.4431739 -1.149566 11.5194202 15.2090476 9.6384789 1.0286949 0.1358432 -0.6575046 0.49895417 0.40673333 0.57246667 0.16573333 1.170050e-09 1.17005e-09 FALSE TRUE
ENST00000677187 ENSG00000166813 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF7 protein_coding retained_intron 23.81287 37.3928 16.84972 2.517807 0.4431739 -1.149566 5.5897169 12.5669144 1.8948600 1.7382549 0.1163805 -2.7230212 0.20158750 0.33503333 0.11230000 -0.22273333 2.975750e-07 1.17005e-09 FALSE TRUE
MSTRG.11504.5 ENSG00000166813 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF7 protein_coding   23.81287 37.3928 16.84972 2.517807 0.4431739 -1.149566 0.9422293 2.9768060 0.0000000 1.3959591 0.0000000 -8.2224597 0.03150833 0.08100000 0.00000000 -0.08100000 4.087632e-06 1.17005e-09 FALSE TRUE
MSTRG.11504.7 ENSG00000166813 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF7 protein_coding   23.81287 37.3928 16.84972 2.517807 0.4431739 -1.149566 0.3076952 0.0000000 1.5336807 0.0000000 0.7700694 7.2702305 0.01508750 0.00000000 0.09246667 0.09246667 1.207467e-01 1.17005e-09 FALSE TRUE
MSTRG.11504.8 ENSG00000166813 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF7 protein_coding   23.81287 37.3928 16.84972 2.517807 0.4431739 -1.149566 1.2198035 0.9028274 1.0354159 0.0787056 0.1331999 0.1956630 0.06208333 0.02460000 0.06146667 0.03686667 5.355277e-03 1.17005e-09 FALSE TRUE
MSTRG.11504.9 ENSG00000166813 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF7 protein_coding   23.81287 37.3928 16.84972 2.517807 0.4431739 -1.149566 2.3616606 3.6736650 0.8033588 0.5018847 0.8033588 -2.1791780 0.10052083 0.09786667 0.04616667 -0.05170000 1.965772e-01 1.17005e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000166813 E001 0.6696487 0.0294589966 6.675801e-02 1.380040e-01 15 89608789 89608968 180 - 0.401 0.083 -2.858
ENSG00000166813 E002 7.7924201 0.0032872582 3.418808e-02 8.012110e-02 15 89618029 89618195 167 - 1.066 0.809 -0.967
ENSG00000166813 E003 74.7118575 0.0174462536 7.389107e-01 8.286730e-01 15 89627977 89628050 74 - 1.802 1.828 0.088
ENSG00000166813 E004 397.1645483 0.0015642215 1.489409e-02 4.024763e-02 15 89628051 89628411 361 - 2.494 2.553 0.197
ENSG00000166813 E005 264.7287125 0.0006373934 1.539118e-05 9.796771e-05 15 89628412 89628559 148 - 2.276 2.387 0.370
ENSG00000166813 E006 119.9809850 0.0002703150 2.833187e-05 1.695054e-04 15 89628560 89628569 10 - 1.903 2.054 0.508
ENSG00000166813 E007 167.1365250 0.0002427751 4.237946e-08 4.638164e-07 15 89628570 89628600 31 - 2.031 2.202 0.572
ENSG00000166813 E008 324.4681766 0.0009226319 8.892083e-07 7.465779e-06 15 89628601 89628786 186 - 2.356 2.479 0.411
ENSG00000166813 E009 303.3661722 0.0003351796 3.871101e-07 3.499062e-06 15 89628976 89629122 147 - 2.331 2.447 0.388
ENSG00000166813 E010 302.2263921 0.0012456667 6.644220e-03 2.030009e-02 15 89629375 89629573 199 - 2.366 2.436 0.232
ENSG00000166813 E011 21.1368694 0.0242921122 5.152089e-03 1.634428e-02 15 89629574 89630286 713 - 1.490 1.196 -1.025
ENSG00000166813 E012 278.3303489 0.0031538200 2.461952e-02 6.109552e-02 15 89630287 89630493 207 - 2.330 2.403 0.241
ENSG00000166813 E013 29.2569385 0.0012458952 3.168712e-08 3.550408e-07 15 89630494 89631362 869 - 1.668 1.297 -1.276
ENSG00000166813 E014 253.3978356 0.0002712311 2.570114e-04 1.204484e-03 15 89631495 89631710 216 - 2.274 2.361 0.290
ENSG00000166813 E015 12.8742347 0.0013792226 3.723509e-04 1.667236e-03 15 89632304 89632819 516 - 1.306 0.962 -1.238
ENSG00000166813 E016 272.2310161 0.0003607101 2.472444e-01 3.826899e-01 15 89632820 89632996 177 - 2.356 2.376 0.068
ENSG00000166813 E017 218.8246945 0.0001832530 3.742696e-01 5.186888e-01 15 89633141 89633266 126 - 2.267 2.282 0.049
ENSG00000166813 E018 6.2602418 0.0027251088 7.201098e-01 8.147797e-01 15 89633267 89633532 266 - 0.850 0.794 -0.217
ENSG00000166813 E019 265.2221190 0.0001800786 4.939562e-01 6.309785e-01 15 89633686 89633883 198 - 2.356 2.363 0.025
ENSG00000166813 E020 273.7432438 0.0001737595 4.006542e-01 5.443297e-01 15 89642203 89642405 203 - 2.367 2.378 0.037
ENSG00000166813 E021 233.5001375 0.0002265420 7.729582e-01 8.534729e-01 15 89645013 89645162 150 - 2.310 2.308 -0.006
ENSG00000166813 E022 45.7698958 0.0004921718 5.730193e-01 6.990237e-01 15 89645163 89645165 3 - 1.591 1.614 0.081
ENSG00000166813 E023 195.6533094 0.0004130087 7.742695e-01 8.544825e-01 15 89645336 89645451 116 - 2.246 2.229 -0.058
ENSG00000166813 E024 195.1051238 0.0002181570 4.068254e-02 9.229168e-02 15 89645893 89646023 131 - 2.277 2.211 -0.222
ENSG00000166813 E025 52.8417949 0.0004723074 1.481962e-01 2.592294e-01 15 89646024 89646026 3 - 1.730 1.644 -0.289
ENSG00000166813 E026 189.2055798 0.0021752057 1.936942e-02 5.013566e-02 15 89646830 89647057 228 - 2.282 2.192 -0.302
ENSG00000166813 E027 86.8478893 0.0003194712 1.319859e-04 6.675478e-04 15 89647596 89647712 117 - 1.997 1.833 -0.549
ENSG00000166813 E028 46.0490121 0.0126005170 1.576039e-05 1.000741e-04 15 89648255 89648380 126 - 1.834 1.499 -1.140
ENSG00000166813 E029 21.3242346 0.0010762971 1.449792e-29 2.341507e-27 15 89648381 89648502 122 - 1.738 0.874 -3.049
ENSG00000166813 E030 116.8106016 0.0066172185 6.123407e-07 5.325290e-06 15 89648503 89648774 272 - 2.186 1.924 -0.878
ENSG00000166813 E031 244.3936300 0.0070983561 5.287128e-03 1.671362e-02 15 89648974 89649367 394 - 2.422 2.290 -0.441
ENSG00000166813 E032 210.3968687 0.0011280349 6.345483e-10 9.770260e-09 15 89649741 89649941 201 - 2.396 2.204 -0.640
ENSG00000166813 E033 21.9897644 0.0008443713 2.232942e-03 7.945310e-03 15 89649942 89650044 103 - 1.468 1.228 -0.835
ENSG00000166813 E034 238.4149876 0.0042836039 1.310260e-03 5.011404e-03 15 89652603 89652954 352 - 2.411 2.279 -0.440
ENSG00000166813 E035 7.4533951 0.1141598577 5.065096e-01 6.421688e-01 15 89654910 89655038 129 - 0.960 0.825 -0.515
ENSG00000166813 E036 53.5633854 0.0008124390 4.505292e-01 5.916252e-01 15 89655399 89655539 141 - 1.709 1.659 -0.169
ENSG00000166813 E037 0.0000000       15 89662924 89663086 163 -