ENSG00000166783

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000396368 ENSG00000166783 HEK293_OSMI2_2hA HEK293_TMG_2hB MARF1 protein_coding protein_coding 8.343196 6.266172 8.060349 0.04962836 0.171584 0.3627462 4.2217093 2.4314669 4.3261306 0.7971591 0.14242315 0.828660 0.4956542 0.389733333 0.53643333 0.14670000 5.791237e-01 2.829098e-07 FALSE TRUE
ENST00000551579 ENSG00000166783 HEK293_OSMI2_2hA HEK293_TMG_2hB MARF1 protein_coding retained_intron 8.343196 6.266172 8.060349 0.04962836 0.171584 0.3627462 0.4270976 0.0513064 0.5326728 0.0513064 0.26956822 3.145973 0.0475000 0.008266667 0.06486667 0.05660000 5.211562e-01 2.829098e-07   FALSE
ENST00000552771 ENSG00000166783 HEK293_OSMI2_2hA HEK293_TMG_2hB MARF1 protein_coding retained_intron 8.343196 6.266172 8.060349 0.04962836 0.171584 0.3627462 1.5911440 2.7333506 0.5504259 0.4503043 0.08650433 -2.291344 0.2114292 0.435400000 0.06866667 -0.36673333 2.829098e-07 2.829098e-07   FALSE
MSTRG.12139.7 ENSG00000166783 HEK293_OSMI2_2hA HEK293_TMG_2hB MARF1 protein_coding   8.343196 6.266172 8.060349 0.04962836 0.171584 0.3627462 0.9514177 0.3947388 1.0264478 0.1833832 0.13724822 1.356584 0.1119333 0.062933333 0.12800000 0.06506667 3.853627e-01 2.829098e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000166783 E001 1.1017542 0.0627538658 3.217559e-02 7.619367e-02 16 15594387 15594387 1 - 0.101 0.532 3.198
ENSG00000166783 E002 439.1249470 0.0190122199 9.431770e-10 1.404733e-08 16 15594388 15596170 1783 - 2.412 2.824 1.372
ENSG00000166783 E003 96.8442061 0.0003491566 3.604036e-06 2.650622e-05 16 15596171 15596634 464 - 1.861 2.104 0.813
ENSG00000166783 E004 18.0134376 0.0131526512 2.797932e-01 4.195635e-01 16 15596635 15596641 7 - 1.187 1.368 0.634
ENSG00000166783 E005 23.7768570 0.0010923872 1.273397e-01 2.304339e-01 16 15596642 15596692 51 - 1.303 1.485 0.630
ENSG00000166783 E006 34.3410642 0.0006521390 9.323021e-01 9.613538e-01 16 15596693 15596766 74 - 1.507 1.587 0.274
ENSG00000166783 E007 41.8373141 0.0043641409 8.883110e-01 9.325855e-01 16 15596767 15596937 171 - 1.587 1.671 0.283
ENSG00000166783 E008 34.7451015 0.0006191755 1.879094e-01 3.110925e-01 16 15598854 15598921 68 - 1.474 1.626 0.521
ENSG00000166783 E009 39.3091143 0.0005185256 2.739079e-01 4.130037e-01 16 15598922 15599024 103 - 1.538 1.673 0.463
ENSG00000166783 E010 4.6146407 0.0073584280 6.348930e-02 1.325092e-01 16 15599025 15599117 93 - 0.830 0.627 -0.831
ENSG00000166783 E011 0.6362506 0.5038934084 6.782110e-01 7.827389e-01 16 15599118 15599171 54 - 0.253 0.148 -0.959
ENSG00000166783 E012 40.8146719 0.0005211018 1.463118e-01 2.566584e-01 16 15600428 15600553 126 - 1.541 1.695 0.526
ENSG00000166783 E013 1.6261932 0.3882395811 7.567394e-01 8.417907e-01 16 15600554 15600640 87 - 0.452 0.351 -0.556
ENSG00000166783 E014 28.9160803 0.0007219651 1.228269e-01 2.239921e-01 16 15600641 15600701 61 - 1.385 1.559 0.597
ENSG00000166783 E015 6.6106882 0.0058774667 3.619153e-03 1.206556e-02 16 15600702 15601863 1162 - 0.984 0.667 -1.243
ENSG00000166783 E016 46.0836756 0.0005805049 7.019219e-01 8.008684e-01 16 15601991 15602127 137 - 1.624 1.719 0.324
ENSG00000166783 E017 41.6868341 0.0004949248 9.031355e-01 9.423834e-01 16 15602128 15602203 76 - 1.593 1.662 0.235
ENSG00000166783 E018 67.8141973 0.0040975566 3.874016e-01 5.315323e-01 16 15604168 15604398 231 - 1.815 1.849 0.112
ENSG00000166783 E019 0.0000000       16 15605848 15606114 267 -      
ENSG00000166783 E020 53.3929787 0.0004759052 4.777163e-02 1.052146e-01 16 15608291 15608518 228 - 1.742 1.723 -0.064
ENSG00000166783 E021 49.1447246 0.0005077164 1.949365e-01 3.199088e-01 16 15609523 15609725 203 - 1.691 1.702 0.037
ENSG00000166783 E022 25.0254542 0.0014115615 5.885019e-02 1.246603e-01 16 15610975 15611029 55 - 1.434 1.374 -0.206
ENSG00000166783 E023 26.3060845 0.0016310629 1.787089e-02 4.685933e-02 16 15611030 15611108 79 - 1.466 1.375 -0.316
ENSG00000166783 E024 37.8330427 0.0067989900 9.591534e-03 2.776155e-02 16 15611592 15611734 143 - 1.626 1.520 -0.363
ENSG00000166783 E025 43.1750368 0.0008314013 2.007269e-02 5.163990e-02 16 15612557 15612705 149 - 1.660 1.610 -0.172
ENSG00000166783 E026 28.8635822 0.0048290229 1.782670e-01 2.989665e-01 16 15612706 15612777 72 - 1.485 1.466 -0.065
ENSG00000166783 E027 40.9629544 0.0011908295 2.091526e-03 7.507119e-03 16 15615830 15616005 176 - 1.665 1.568 -0.330
ENSG00000166783 E028 0.0000000       16 15616785 15617051 267 -      
ENSG00000166783 E029 32.4675852 0.0007733916 1.492263e-04 7.437055e-04 16 15617052 15617171 120 - 1.590 1.430 -0.551
ENSG00000166783 E030 0.1515154 0.0428852142 6.187304e-01   16 15617172 15617298 127 - 0.101 0.000 -18.745
ENSG00000166783 E031 33.5312215 0.0005910490 5.844225e-05 3.237153e-04 16 15617299 15617535 237 - 1.602 1.430 -0.589
ENSG00000166783 E032 5.5337190 0.0036422408 3.374632e-01 4.813567e-01 16 15619552 15619706 155 - 0.830 0.768 -0.243
ENSG00000166783 E033 17.7708196 0.0010704080 1.299735e-01 2.341310e-01 16 15620451 15620531 81 - 1.286 1.236 -0.177
ENSG00000166783 E034 1.1909051 0.0109574856 5.022040e-03 1.599170e-02 16 15621493 15621732 240 - 0.490 0.000 -21.745
ENSG00000166783 E035 29.3494614 0.0324907794 1.768261e-01 2.971207e-01 16 15621733 15621911 179 - 1.501 1.438 -0.214
ENSG00000166783 E036 26.7404653 0.0265427902 2.505255e-01 3.865651e-01 16 15622934 15623057 124 - 1.450 1.412 -0.132
ENSG00000166783 E037 18.7388391 0.0869844868 3.621467e-01 5.065386e-01 16 15623058 15623096 39 - 1.303 1.265 -0.134
ENSG00000166783 E038 13.0101696 0.0394172458 4.093451e-02 9.276220e-02 16 15623097 15623123 27 - 1.209 1.021 -0.677
ENSG00000166783 E039 3.3925141 0.0045608864 3.444600e-01 4.885450e-01 16 15623124 15623126 3 - 0.669 0.584 -0.369
ENSG00000166783 E040 0.3030308 0.3699943410 3.781621e-01   16 15623127 15623150 24 - 0.183 0.000 -19.752
ENSG00000166783 E041 28.8362148 0.0355999406 2.517354e-02 6.223398e-02 16 15624769 15624927 159 - 1.531 1.368 -0.560
ENSG00000166783 E042 24.4677143 0.0165891117 4.642974e-03 1.493932e-02 16 15625016 15625173 158 - 1.474 1.286 -0.652
ENSG00000166783 E043 43.7755034 0.0334681058 7.923718e-03 2.358738e-02 16 15625372 15625797 426 - 1.716 1.541 -0.595
ENSG00000166783 E044 8.9013068 0.0132580175 2.706644e-01 4.092920e-01 16 15625798 15625800 3 - 1.018 0.959 -0.219
ENSG00000166783 E045 0.0000000       16 15630234 15630331 98 -      
ENSG00000166783 E046 25.1187026 0.0055902159 9.428822e-04 3.764276e-03 16 15630332 15630504 173 - 1.485 1.302 -0.634
ENSG00000166783 E047 22.0030623 0.0402128416 1.341259e-01 2.398934e-01 16 15631381 15631498 118 - 1.402 1.301 -0.354
ENSG00000166783 E048 27.6775575 0.0171782711 1.621623e-03 6.030259e-03 16 15633617 15633834 218 - 1.534 1.321 -0.735
ENSG00000166783 E049 11.7764166 0.0021557288 3.103031e-02 7.397720e-02 16 15633835 15633843 9 - 1.157 1.014 -0.518
ENSG00000166783 E050 23.7262538 0.0101987054 9.324761e-05 4.902992e-04 16 15634757 15634931 175 - 1.485 1.216 -0.937
ENSG00000166783 E051 0.0000000       16 15634932 15635655 724 -      
ENSG00000166783 E052 35.7303577 0.0162271935 1.646979e-07 1.604439e-06 16 15635656 15635993 338 - 1.691 1.310 -1.308
ENSG00000166783 E053 16.1203881 0.0087741794 5.530461e-06 3.898266e-05 16 15635994 15636045 52 - 1.361 0.978 -1.369
ENSG00000166783 E054 42.9232461 0.0005290585 1.924294e-09 2.704389e-08 16 15636046 15636342 297 - 1.733 1.473 -0.885
ENSG00000166783 E055 24.9098014 0.0007670219 4.103364e-04 1.813811e-03 16 15639090 15639291 202 - 1.478 1.302 -0.610
ENSG00000166783 E056 0.1515154 0.0428852142 6.187304e-01   16 15642459 15642488 30 - 0.101 0.000 -18.745
ENSG00000166783 E057 5.6768561 0.0030274021 1.138933e-01 2.111992e-01 16 15643018 15643154 137 - 0.877 0.737 -0.554