ENSG00000166747

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000299980 ENSG00000166747 HEK293_OSMI2_2hA HEK293_TMG_2hB AP1G1 protein_coding protein_coding 26.04688 16.98657 35.22861 2.407095 0.06463961 1.051914 19.316119 14.5944156 24.104027 1.7641304 0.9197879 0.723468 0.7660708 0.86753333 0.6843 -0.1832333 5.820976e-02 1.436348e-13 FALSE TRUE
ENST00000393512 ENSG00000166747 HEK293_OSMI2_2hA HEK293_TMG_2hB AP1G1 protein_coding protein_coding 26.04688 16.98657 35.22861 2.407095 0.06463961 1.051914 3.262503 0.4698124 5.704028 0.1027067 0.3911428 3.573966 0.1026208 0.02766667 0.1619 0.1342333 1.436348e-13 1.436348e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000166747 E001 1728.2575309 0.0050310509 3.983995e-19 2.301085e-17 16 71729000 71731882 2883 - 3.085 3.392 1.021
ENSG00000166747 E002 426.2380346 0.0001963855 1.230215e-13 3.451725e-12 16 71731883 71732384 502 - 2.531 2.737 0.686
ENSG00000166747 E003 197.9372465 0.0008120496 3.589089e-03 1.197967e-02 16 71732385 71732534 150 - 2.221 2.377 0.520
ENSG00000166747 E004 174.0140688 0.0002774375 1.347019e-03 5.133135e-03 16 71732535 71732602 68 - 2.162 2.325 0.543
ENSG00000166747 E005 279.5172864 0.0021801140 1.924119e-01 3.167991e-01 16 71732603 71732799 197 - 2.388 2.502 0.380
ENSG00000166747 E006 344.9160019 0.0002179141 1.616587e-01 2.772767e-01 16 71732800 71733159 360 - 2.485 2.587 0.340
ENSG00000166747 E007 0.7696683 0.0160855470 7.929343e-01 8.675950e-01 16 71734571 71734608 38 - 0.217 0.297 0.603
ENSG00000166747 E008 147.4254399 0.0015996773 1.447084e-01 2.544417e-01 16 71734609 71734707 99 - 2.107 2.229 0.409
ENSG00000166747 E009 177.2027636 0.0002344521 6.814908e-01 7.851569e-01 16 71738942 71739102 161 - 2.210 2.272 0.207
ENSG00000166747 E010 130.9522588 0.0002430786 6.213535e-03 1.917596e-02 16 71739234 71739341 108 - 2.109 2.093 -0.054
ENSG00000166747 E011 0.7406253 0.0153974876 8.505850e-02 1.674998e-01 16 71742282 71743593 1312 - 0.318 0.000 -12.950
ENSG00000166747 E012 146.4071107 0.0020097833 1.481380e-03 5.576943e-03 16 71745144 71745270 127 - 2.166 2.120 -0.156
ENSG00000166747 E013 174.9151073 0.0002065364 4.049693e-06 2.941275e-05 16 71745473 71745614 142 - 2.248 2.189 -0.195
ENSG00000166747 E014 152.1411927 0.0002101546 8.307921e-03 2.456357e-02 16 71746588 71746692 105 - 2.169 2.163 -0.022
ENSG00000166747 E015 3.0397040 0.0051392830 1.272138e-02 3.525700e-02 16 71746693 71747396 704 - 0.688 0.297 -1.981
ENSG00000166747 E016 88.2691548 0.0002839715 9.847873e-02 1.881834e-01 16 71748251 71748267 17 - 1.931 1.939 0.028
ENSG00000166747 E017 133.7802886 0.0006707407 1.584841e-01 2.731025e-01 16 71748268 71748378 111 - 2.104 2.130 0.087
ENSG00000166747 E018 83.2410503 0.0004447783 3.973281e-01 5.410854e-01 16 71749894 71749918 25 - 1.895 1.934 0.130
ENSG00000166747 E019 89.3309723 0.0004199225 1.598312e-01 2.748962e-01 16 71749919 71749983 65 - 1.930 1.947 0.057
ENSG00000166747 E020 132.4598600 0.0004731825 1.477724e-05 9.445016e-05 16 71750210 71750332 123 - 2.131 2.057 -0.248
ENSG00000166747 E021 0.2966881 0.0270410860 4.595978e-01   16 71750333 71750480 148 - 0.156 0.000 -11.568
ENSG00000166747 E022 0.1451727 0.0440092630 1.000000e+00   16 71751263 71751337 75 - 0.085 0.000 -10.476
ENSG00000166747 E023 1.3641904 0.0107054280 1.149376e-01 2.127497e-01 16 71753570 71753832 263 - 0.435 0.174 -1.811
ENSG00000166747 E024 98.7271728 0.0003049443 3.218833e-05 1.900216e-04 16 71753833 71753887 55 - 2.008 1.922 -0.290
ENSG00000166747 E025 0.4470576 0.0215717951 1.000000e+00 1.000000e+00 16 71755965 71756018 54 - 0.156 0.173 0.186
ENSG00000166747 E026 149.7384479 0.0023417595 3.091419e-04 1.416725e-03 16 71756019 71756159 141 - 2.181 2.111 -0.234
ENSG00000166747 E027 1.4652396 0.0184541769 5.336861e-01 6.658415e-01 16 71756160 71756324 165 - 0.318 0.472 0.868
ENSG00000166747 E028 121.4207753 0.0105587359 2.678062e-02 6.553480e-02 16 71758808 71758896 89 - 2.088 2.026 -0.209
ENSG00000166747 E029 78.4942465 0.0171227863 2.622823e-02 6.441186e-02 16 71758897 71758921 25 - 1.912 1.812 -0.336
ENSG00000166747 E030 96.1206763 0.0018657232 7.289233e-07 6.237515e-06 16 71761512 71761567 56 - 2.013 1.862 -0.507
ENSG00000166747 E031 0.3030308 0.3866710047 5.777038e-01   16 71764346 71764349 4 - 0.156 0.000 -9.456
ENSG00000166747 E032 119.2329315 0.0051607765 1.263235e-06 1.026623e-05 16 71764350 71764448 99 - 2.113 1.936 -0.592
ENSG00000166747 E033 112.2636537 0.0058773129 2.047812e-06 1.589380e-05 16 71764646 71764726 81 - 2.089 1.905 -0.617
ENSG00000166747 E034 105.2532094 0.0003449626 1.430261e-10 2.459237e-09 16 71765489 71765584 96 - 2.060 1.887 -0.580
ENSG00000166747 E035 0.4418608 0.0259578909 2.507142e-01 3.867806e-01 16 71765585 71765650 66 - 0.217 0.000 -12.158
ENSG00000166747 E036 15.6097818 0.0402592352 2.719584e-01 4.107770e-01 16 71767877 71767885 9 - 1.230 1.160 -0.249
ENSG00000166747 E037 0.1515154 0.0440674153 1.000000e+00   16 71769619 71769622 4 - 0.085 0.000 -10.476
ENSG00000166747 E038 81.1088818 0.0003344557 1.317791e-05 8.512252e-05 16 71769623 71769699 77 - 1.933 1.822 -0.375
ENSG00000166747 E039 0.4751703 0.0203830497 2.581715e-01 3.954002e-01 16 71771140 71771155 16 - 0.085 0.297 2.187
ENSG00000166747 E040 43.2622378 0.0005400799 5.019753e-03 1.598496e-02 16 71771156 71771159 4 - 1.659 1.572 -0.296
ENSG00000166747 E041 84.5562052 0.0003372661 7.061091e-07 6.058161e-06 16 71771160 71771252 93 - 1.956 1.822 -0.454
ENSG00000166747 E042 0.0000000       16 71772960 71773053 94 -      
ENSG00000166747 E043 67.2692304 0.0015895444 1.508679e-05 9.625659e-05 16 71773221 71773254 34 - 1.861 1.716 -0.488
ENSG00000166747 E044 52.6216163 0.0023682578 1.472578e-03 5.547887e-03 16 71773255 71773269 15 - 1.745 1.636 -0.370
ENSG00000166747 E045 102.0266564 0.0043064843 7.008342e-07 6.017264e-06 16 71773270 71773362 93 - 2.047 1.867 -0.605
ENSG00000166747 E046 0.1472490 0.0454158713 1.000000e+00   16 71774332 71774467 136 - 0.085 0.000 -10.468
ENSG00000166747 E047 87.0577985 0.0028186002 2.945953e-08 3.320454e-07 16 71774468 71774518 51 - 1.985 1.781 -0.685
ENSG00000166747 E048 67.9695969 0.0048468998 4.135635e-05 2.375776e-04 16 71774519 71774536 18 - 1.870 1.704 -0.562
ENSG00000166747 E049 92.6615500 0.0003298824 1.202775e-10 2.094898e-09 16 71774537 71774592 56 - 2.009 1.818 -0.641
ENSG00000166747 E050 87.1711060 0.0006737138 8.153857e-12 1.722484e-10 16 71789279 71789319 41 - 1.992 1.767 -0.759
ENSG00000166747 E051 59.8550333 0.0004276361 9.775390e-09 1.207642e-07 16 71789320 71789322 3 - 1.830 1.611 -0.743
ENSG00000166747 E052 104.2074392 0.0063347148 5.541776e-08 5.912778e-07 16 71789323 71789399 77 - 2.070 1.839 -0.778
ENSG00000166747 E053 94.6467897 0.0034031357 2.754840e-10 4.509990e-09 16 71789400 71789480 81 - 2.032 1.787 -0.823
ENSG00000166747 E054 49.9164622 0.0004651021 3.347976e-08 3.736460e-07 16 71789481 71789482 2 - 1.755 1.518 -0.806
ENSG00000166747 E055 1.0373134 0.0117470147 3.180641e-02 7.548266e-02 16 71806686 71806728 43 - 0.399 0.000 -13.453
ENSG00000166747 E056 3.1807094 0.0644150150 1.060375e-01 1.996650e-01 16 71807801 71807838 38 - 0.669 0.397 -1.295
ENSG00000166747 E057 2.4422743 0.2580918630 4.209131e-01 5.640728e-01 16 71807839 71807906 68 - 0.555 0.405 -0.746
ENSG00000166747 E058 1.4101723 0.0097042911 9.547535e-01 9.756470e-01 16 71807907 71808014 108 - 0.360 0.393 0.188
ENSG00000166747 E059 11.6978574 0.0608869041 1.558299e-01 2.695462e-01 16 71808015 71808150 136 - 1.130 0.992 -0.503
ENSG00000166747 E060 1.0738451 0.0115906017 2.397638e-01 3.738419e-01 16 71808151 71808294 144 - 0.360 0.174 -1.396
ENSG00000166747 E061 0.4815130 0.0203137791 2.583741e-01 3.956209e-01 16 71808357 71808504 148 - 0.085 0.297 2.187
ENSG00000166747 E062 12.1476811 0.0014731864 4.249368e-01 5.678897e-01 16 71808505 71808671 167 - 1.102 1.090 -0.043
ENSG00000166747 E063 4.9177719 0.0038992321 1.666333e-01 2.838074e-01 16 71808672 71808677 6 - 0.791 0.648 -0.588
ENSG00000166747 E064 5.5873174 0.0931508920 9.646567e-01 9.817000e-01 16 71808678 71808762 85 - 0.776 0.816 0.158
ENSG00000166747 E065 81.6992919 0.0003451576 2.049613e-10 3.427426e-09 16 71808763 71808921 159 - 1.957 1.752 -0.692
ENSG00000166747 E066 52.0070053 0.0004548061 3.997796e-08 4.397181e-07 16 71808922 71809201 280 - 1.771 1.543 -0.774