ENSG00000166710

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000561424 ENSG00000166710 HEK293_OSMI2_2hA HEK293_TMG_2hB B2M protein_coding nonsense_mediated_decay 147.0379 118.8787 183.9191 28.32614 2.267231 0.6295386 5.614599 0.0000 13.20042 0.00000 3.788356 10.3674604 0.02962917 0.0000000 0.0714 0.07140000 7.754111e-18 7.754111e-18 TRUE  
ENST00000648006 ENSG00000166710 HEK293_OSMI2_2hA HEK293_TMG_2hB B2M protein_coding protein_coding 147.0379 118.8787 183.9191 28.32614 2.267231 0.6295386 139.902912 118.1997 168.51399 28.17606 2.035759 0.5116061 0.95990833 0.9942333 0.9166 -0.07763333 8.254962e-15 7.754111e-18 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000166710 E001 0.2966881 0.0274221066 2.803619e-01   15 44711358 44711415 58 + 0.200 0.000 -10.875
ENSG00000166710 E002 0.3332198 0.0433168704 8.818012e-01   15 44711416 44711440 25 + 0.112 0.134 0.306
ENSG00000166710 E003 0.3332198 0.0433168704 8.818012e-01   15 44711441 44711486 46 + 0.112 0.134 0.306
ENSG00000166710 E004 2.2497729 0.0065795818 4.385287e-02 9.811507e-02 15 44711487 44711508 22 + 0.654 0.319 -1.695
ENSG00000166710 E005 3.1095346 0.0048254032 4.122637e-04 1.821466e-03 15 44711509 44711512 4 + 0.817 0.236 -2.943
ENSG00000166710 E006 3.3966577 0.0045199533 1.063666e-03 4.179543e-03 15 44711513 44711516 4 + 0.836 0.319 -2.432
ENSG00000166710 E007 3.5783621 0.0044932476 3.527861e-03 1.180671e-02 15 44711517 44711518 2 + 0.836 0.388 -2.017
ENSG00000166710 E008 718.2423740 0.0031332795 2.428759e-01 3.775601e-01 15 44711519 44711603 85 + 2.883 2.836 -0.155
ENSG00000166710 E009 679.7129972 0.0020065455 5.568100e-01 6.853878e-01 15 44711604 44711613 10 + 2.849 2.825 -0.081
ENSG00000166710 E010 0.4031496 0.0894501634 1.487671e-01 2.600120e-01 15 44711927 44711958 32 + 0.000 0.238 11.222
ENSG00000166710 E011 0.3666179 0.0461734082 8.774594e-01 9.252738e-01 15 44711959 44712020 62 + 0.111 0.134 0.311
ENSG00000166710 E012 557.0472455 0.0009005563 6.782016e-01 7.827356e-01 15 44715423 44715433 11 + 2.759 2.748 -0.038
ENSG00000166710 E013 943.9603759 0.0001352256 3.188718e-06 2.371503e-05 15 44715434 44715499 66 + 3.008 2.957 -0.171
ENSG00000166710 E014 868.4103358 0.0001213192 2.981180e-01 4.395210e-01 15 44715500 44715545 46 + 2.952 2.945 -0.024
ENSG00000166710 E015 1396.5782018 0.0001097966 1.526292e-02 4.108304e-02 15 44715546 44715701 156 + 3.163 3.146 -0.059
ENSG00000166710 E016 6.3598773 0.0923627240 7.332272e-04 3.018813e-03 15 44715702 44715725 24 + 1.085 0.388 -2.952
ENSG00000166710 E017 1.2221382 0.0104441554 2.444158e-01 3.793710e-01 15 44715726 44715816 91 + 0.440 0.236 -1.280
ENSG00000166710 E018 1.0319116 0.0167805596 2.907125e-01 4.315183e-01 15 44715817 44715877 61 + 0.200 0.389 1.306
ENSG00000166710 E019 7.3913950 0.0843548338 3.031563e-01 4.450476e-01 15 44715878 44716328 451 + 1.017 0.822 -0.739
ENSG00000166710 E020 616.9531185 0.0004045276 5.254454e-01 6.588176e-01 15 44716329 44716356 28 + 2.792 2.809 0.057
ENSG00000166710 E021 36.9987294 0.0008328936 2.489149e-05 1.510496e-04 15 44716357 44716619 263 + 1.693 1.454 -0.815
ENSG00000166710 E022 24.3678639 0.0007833113 4.196255e-01 5.628809e-01 15 44716620 44717606 987 + 1.437 1.389 -0.165
ENSG00000166710 E023 842.3511617 0.0007248441 1.761372e-03 6.476082e-03 15 44717607 44717704 98 + 2.906 2.959 0.175
ENSG00000166710 E024 916.3174918 0.0005354664 2.394631e-01 3.734960e-01 15 44717705 44717791 87 + 2.960 2.981 0.070
ENSG00000166710 E025 750.5186679 0.0001282363 1.960820e-02 5.064715e-02 15 44717792 44717843 52 + 2.868 2.906 0.127
ENSG00000166710 E026 857.1349801 0.0012026593 3.098777e-05 1.837645e-04 15 44717844 44718145 302 + 2.896 2.981 0.283
ENSG00000166710 E027 0.0000000       15 44718758 44718851 94 +