ENSG00000166704

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000341164 ENSG00000166704 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF606 protein_coding protein_coding 1.530514 0.7714666 1.587921 0.06730109 0.09973609 1.03194 0.2590299 0.00000000 0.26347375 0.000000000 0.14066791 4.7733304 0.14045000 0.00000000 0.17563333 0.17563333 0.328091398 0.001100443 FALSE TRUE
ENST00000546715 ENSG00000166704 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF606 protein_coding protein_coding 1.530514 0.7714666 1.587921 0.06730109 0.09973609 1.03194 0.0934983 0.03497181 0.05524749 0.004157047 0.01427514 0.5369015 0.06670833 0.04643333 0.03403333 -0.01240000 1.000000000 0.001100443 TRUE FALSE
ENST00000547828 ENSG00000166704 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF606 protein_coding protein_coding 1.530514 0.7714666 1.587921 0.06730109 0.09973609 1.03194 0.4950309 0.35888274 0.27604270 0.033342434 0.01513428 -0.3669318 0.34330833 0.46596667 0.17436667 -0.29160000 0.001100443 0.001100443 FALSE FALSE
ENST00000550599 ENSG00000166704 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF606 protein_coding nonsense_mediated_decay 1.530514 0.7714666 1.587921 0.06730109 0.09973609 1.03194 0.1529686 0.08124359 0.46100961 0.081243593 0.22078430 2.3679613 0.10551250 0.12700000 0.27990000 0.15290000 0.485142809 0.001100443 FALSE TRUE
ENST00000551380 ENSG00000166704 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF606 protein_coding protein_coding 1.530514 0.7714666 1.587921 0.06730109 0.09973609 1.03194 0.4564079 0.29636847 0.46238799 0.123063866 0.07716548 0.6247044 0.30241667 0.36060000 0.29553333 -0.06506667 0.871671573 0.001100443 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000166704 E001 73.5743581 0.0006815237 4.046650e-02 9.187686e-02 19 57977076 57980279 3204 - 1.887 1.807 -0.272
ENSG00000166704 E002 8.7060236 0.1401964332 4.133493e-01 5.568554e-01 19 57988207 57988302 96 - 1.018 0.863 -0.582
ENSG00000166704 E003 7.6644333 0.1121037625 2.511588e-01 3.873214e-01 19 57988595 57988675 81 - 0.988 0.763 -0.865
ENSG00000166704 E004 3.2452295 0.0086347784 1.392884e-02 3.806386e-02 19 57988676 57988721 46 - 0.730 0.284 -2.245
ENSG00000166704 E005 17.5580148 0.0012860081 1.278773e-11 2.616760e-10 19 57997396 57999263 1868 - 0.999 1.503 1.781
ENSG00000166704 E006 11.2583756 0.0020583302 8.408747e-05 4.474375e-04 19 57999264 57999807 544 - 0.910 1.267 1.294
ENSG00000166704 E007 6.5405418 0.0028828654 5.822823e-01 7.066593e-01 19 57999808 57999896 89 - 0.898 0.814 -0.322
ENSG00000166704 E008 0.8481309 0.0146533002 2.113456e-01 3.400727e-01 19 58000224 58000570 347 - 0.164 0.377 1.586
ENSG00000166704 E009 0.5503986 0.0223345778 2.283556e-01 3.604656e-01 19 58000571 58000682 112 - 0.090 0.284 2.004
ENSG00000166704 E010 7.5360155 0.0026163844 2.466707e-03 8.664002e-03 19 58000683 58000739 57 - 1.037 0.625 -1.619
ENSG00000166704 E011 0.3030308 0.3489990120 5.934444e-01   19 58001157 58001288 132 - 0.165 0.000 -9.993
ENSG00000166704 E012 5.5663828 0.0293162308 4.333081e-02 9.716851e-02 19 58001289 58001370 82 - 0.911 0.574 -1.379
ENSG00000166704 E013 4.4703984 0.0040594697 8.617134e-01 9.148371e-01 19 58002396 58002779 384 - 0.748 0.711 -0.152
ENSG00000166704 E014 1.1888288 0.0158578351 2.463657e-02 6.113225e-02 19 58002780 58003349 570 - 0.453 0.000 -12.586