ENSG00000166669

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000396560 ENSG00000166669 HEK293_OSMI2_2hA HEK293_TMG_2hB ATF7IP2 protein_coding protein_coding 9.000583 7.07352 11.64301 1.448345 0.6353905 0.7181636 0.5306996 0.3541306 0.60856955 0.12348866 0.36777946 0.7644798 0.06172500 0.05236667 0.05603333 0.003666667 0.90365982 0.04232911 FALSE  
ENST00000543967 ENSG00000166669 HEK293_OSMI2_2hA HEK293_TMG_2hB ATF7IP2 protein_coding protein_coding 9.000583 7.07352 11.64301 1.448345 0.6353905 0.7181636 0.2803457 0.4104169 0.06719488 0.13419264 0.06719488 -2.4452435 0.05050833 0.05656667 0.00580000 -0.050766667 0.04232911 0.04232911 FALSE  
ENST00000562396 ENSG00000166669 HEK293_OSMI2_2hA HEK293_TMG_2hB ATF7IP2 protein_coding retained_intron 9.000583 7.07352 11.64301 1.448345 0.6353905 0.7181636 0.4324373 0.2814823 0.49901926 0.06105851 0.10696813 0.8043121 0.05402083 0.03986667 0.04356667 0.003700000 0.95714441 0.04232911    
ENST00000566316 ENSG00000166669 HEK293_OSMI2_2hA HEK293_TMG_2hB ATF7IP2 protein_coding retained_intron 9.000583 7.07352 11.64301 1.448345 0.6353905 0.7181636 6.5984858 5.5437926 9.25782514 1.19020148 0.63814692 0.7387575 0.70121250 0.78353333 0.79390000 0.010366667 0.93849404 0.04232911    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000166669 E001 0.0000000       16 10326434 10326512 79 +      
ENSG00000166669 E002 0.0000000       16 10344001 10344190 190 +      
ENSG00000166669 E003 0.0000000       16 10385152 10385253 102 +      
ENSG00000166669 E004 1.4445259 0.0100831139 0.14643934 0.25683926 16 10386039 10386054 16 + 0.265 0.514 1.434
ENSG00000166669 E005 1.5928190 0.0096803355 0.08194913 0.16261112 16 10386055 10386057 3 + 0.265 0.562 1.656
ENSG00000166669 E006 1.5928190 0.0096803355 0.08194913 0.16261112 16 10386058 10386058 1 + 0.265 0.562 1.656
ENSG00000166669 E007 1.5928190 0.0096803355 0.08194913 0.16261112 16 10386059 10386060 2 + 0.265 0.562 1.656
ENSG00000166669 E008 25.6301223 0.0008014910 0.17443610 0.29395424 16 10386061 10386122 62 + 1.470 1.375 -0.330
ENSG00000166669 E009 11.6133573 0.0559708096 0.47531162 0.61402106 16 10386123 10387091 969 + 1.150 1.025 -0.453
ENSG00000166669 E010 2.2163697 0.0069854168 0.05156263 0.11193036 16 10387092 10387143 52 + 0.326 0.644 1.606
ENSG00000166669 E011 53.5302806 0.0005153301 0.88823103 0.93255323 16 10387144 10387290 147 + 1.747 1.735 -0.040
ENSG00000166669 E012 3.6021265 0.0087552150 0.01680233 0.04449845 16 10387291 10387377 87 + 0.471 0.824 1.534
ENSG00000166669 E013 58.2761563 0.0014447078 0.40057793 0.54426346 16 10387378 10387484 107 + 1.764 1.796 0.108
ENSG00000166669 E014 27.6305054 0.0198564184 0.73114590 0.82287794 16 10387485 10387494 10 + 1.445 1.489 0.151
ENSG00000166669 E015 44.0668267 0.0036388213 0.09269074 0.17933356 16 10387495 10387741 247 + 1.619 1.707 0.301
ENSG00000166669 E016 0.5954526 0.0182640508 0.07732372 0.15519384 16 10414574 10414612 39 + 0.326 0.000 -11.516
ENSG00000166669 E017 0.7718584 0.0159028519 0.92344939 0.95575748 16 10414910 10414946 37 + 0.265 0.245 -0.149
ENSG00000166669 E018 0.9254501 0.0133132773 0.66153950 0.76997594 16 10419581 10419623 43 + 0.326 0.245 -0.565
ENSG00000166669 E019 3.1604441 0.0252832762 0.64444948 0.75674918 16 10428868 10428900 33 + 0.579 0.645 0.290
ENSG00000166669 E020 5.8479106 0.0442830221 0.61750175 0.73528506 16 10428901 10429016 116 + 0.871 0.776 -0.371
ENSG00000166669 E021 0.7310603 0.0927820854 0.32893064 0.47241558 16 10429372 10429413 42 + 0.326 0.139 -1.569
ENSG00000166669 E022 0.0000000       16 10430595 10430610 16 +      
ENSG00000166669 E023 22.8561792 0.0256687237 0.05036906 0.10982515 16 10430611 10431455 845 + 1.462 1.242 -0.764
ENSG00000166669 E024 6.8505677 0.0087439811 0.09855354 0.18828456 16 10433525 10433649 125 + 0.985 0.772 -0.818
ENSG00000166669 E025 6.9281261 0.0090849429 0.10981506 0.20529045 16 10438101 10438235 135 + 0.985 0.773 -0.816
ENSG00000166669 E026 5.0427836 0.0708248495 0.15161220 0.26385269 16 10440364 10440462 99 + 0.887 0.608 -1.134
ENSG00000166669 E027 0.2987644 0.0272370077 0.31577065   16 10454022 10454339 318 + 0.193 0.000 -10.618
ENSG00000166669 E028 0.1515154 0.0432900759 0.68267349   16 10457320 10457371 52 + 0.107 0.000 -9.650
ENSG00000166669 E029 5.4262636 0.0201374434 0.71724158 0.81268961 16 10457372 10457529 158 + 0.837 0.772 -0.256
ENSG00000166669 E030 0.0000000       16 10457530 10457611 82 +      
ENSG00000166669 E031 0.9631146 0.0135263995 0.66116318 0.76967033 16 10471924 10472109 186 + 0.326 0.245 -0.563
ENSG00000166669 E032 4.9186100 0.0033907840 0.39183564 0.53577832 16 10472110 10472183 74 + 0.716 0.825 0.436
ENSG00000166669 E033 4.8768840 0.0035406938 0.26247055 0.40025645 16 10473479 10473534 56 + 0.837 0.680 -0.634
ENSG00000166669 E034 6.6701335 0.0131320901 0.28933921 0.43003158 16 10473923 10473989 67 + 0.946 0.800 -0.562
ENSG00000166669 E035 8.4070586 0.0027446383 0.02994348 0.07184639 16 10480879 10480964 86 + 1.076 0.825 -0.942
ENSG00000166669 E036 54.7565146 0.0004721394 0.02763200 0.06727756 16 10481836 10483638 1803 + 1.703 1.794 0.308