ENSG00000166582

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000299736 ENSG00000166582 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPV protein_coding protein_coding 285.3572 512.8342 162.6323 13.63798 2.932863 -1.656818 124.45618 224.85682 67.08467 14.967160 0.7438357 -1.7448008 0.4129500 0.44056667 0.4128333 -0.02773333 8.397042e-01 2.012528e-12 FALSE TRUE
ENST00000472570 ENSG00000166582 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPV protein_coding retained_intron 285.3572 512.8342 162.6323 13.63798 2.932863 -1.656818 101.47696 219.22396 38.43842 26.695703 4.8646378 -2.5114752 0.3348375 0.42533333 0.2356000 -0.18973333 7.571472e-03 2.012528e-12   FALSE
ENST00000476243 ENSG00000166582 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPV protein_coding nonsense_mediated_decay 285.3572 512.8342 162.6323 13.63798 2.932863 -1.656818 24.90775 28.21854 23.90494 2.558052 0.6472793 -0.2392426 0.1044500 0.05523333 0.1471333 0.09190000 4.855498e-10 2.012528e-12 TRUE TRUE
ENST00000631687 ENSG00000166582 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPV protein_coding processed_transcript 285.3572 512.8342 162.6323 13.63798 2.932863 -1.656818 17.27780 21.76092 16.33849 1.462051 0.8134597 -0.4132452 0.0721250 0.04240000 0.1005667 0.05816667 2.012528e-12 2.012528e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000166582 E001 1.141495 0.0132484782 5.477281e-01 6.777227e-01 17 16340252 16340310 59 - 0.206 0.311 0.782
ENSG00000166582 E002 5.534318 0.0466352747 7.889477e-01 8.648946e-01 17 16342534 16342534 1 - 0.720 0.749 0.117
ENSG00000166582 E003 16.250183 0.0011230160 4.291273e-01 5.718609e-01 17 16342535 16342536 2 - 1.098 1.149 0.181
ENSG00000166582 E004 2872.447900 0.0006292389 4.030840e-19 2.326014e-17 17 16342537 16342834 298 - 3.282 3.371 0.297
ENSG00000166582 E005 1471.412906 0.0006058715 2.052956e-09 2.867342e-08 17 16342835 16342841 7 - 3.013 3.077 0.213
ENSG00000166582 E006 1446.901658 0.0009653244 1.282685e-07 1.276064e-06 17 16342842 16342843 2 - 3.004 3.070 0.217
ENSG00000166582 E007 1484.656675 0.0009097298 3.536287e-07 3.223030e-06 17 16342844 16342845 2 - 3.020 3.080 0.197
ENSG00000166582 E008 2030.412909 0.0007439610 1.939911e-10 3.256916e-09 17 16342846 16342873 28 - 3.150 3.217 0.222
ENSG00000166582 E009 2481.550975 0.0001307594 6.671117e-27 8.533579e-25 17 16342874 16342941 68 - 3.231 3.305 0.244
ENSG00000166582 E010 3006.064855 0.0001026172 2.176413e-19 1.300678e-17 17 16344597 16344711 115 - 3.338 3.383 0.150
ENSG00000166582 E011 13.588369 0.0024403056 1.211126e-04 6.190823e-04 17 16344712 16344742 31 - 1.359 0.963 -1.416
ENSG00000166582 E012 27.759812 0.0007358247 4.712262e-41 1.733445e-38 17 16347211 16347315 105 - 1.899 0.988 -3.168
ENSG00000166582 E013 17.733974 0.0088898894 5.817421e-27 7.476885e-25 17 16347316 16347359 44 - 1.746 0.729 -3.651
ENSG00000166582 E014 14.844197 0.0124204045 1.068584e-16 4.580090e-15 17 16348037 16348037 1 - 1.626 0.779 -3.041
ENSG00000166582 E015 270.945186 0.0033455438 9.864671e-12 2.056826e-10 17 16348038 16348474 437 - 2.544 2.264 -0.934
ENSG00000166582 E016 167.572136 0.0051356271 7.192794e-12 1.533138e-10 17 16348475 16348573 99 - 2.378 2.037 -1.142
ENSG00000166582 E017 151.279894 0.0020748916 1.575388e-11 3.175028e-10 17 16348574 16348615 42 - 2.299 2.012 -0.961
ENSG00000166582 E018 2032.749102 0.0002473253 1.308437e-05 8.456009e-05 17 16348616 16348685 70 - 3.191 3.208 0.056
ENSG00000166582 E019 703.554635 0.0047351649 5.605461e-19 3.181359e-17 17 16348686 16349023 338 - 3.004 2.652 -1.171
ENSG00000166582 E020 556.568242 0.0056927191 1.043397e-20 7.291346e-19 17 16349024 16349139 116 - 2.935 2.533 -1.339
ENSG00000166582 E021 681.821804 0.0031996062 2.237049e-36 5.985908e-34 17 16349140 16349333 194 - 3.033 2.614 -1.391
ENSG00000166582 E022 18.886572 0.0086326569 2.474885e-05 1.503126e-04 17 16349334 16349349 16 - 1.505 1.095 -1.437
ENSG00000166582 E023 13.205934 0.0015810618 1.210462e-06 9.877179e-06 17 16349350 16349356 7 - 1.403 0.920 -1.730
ENSG00000166582 E024 45.455963 0.0067371598 3.320439e-24 3.367490e-22 17 16349502 16349713 212 - 2.011 1.318 -2.358
ENSG00000166582 E025 34.167521 0.0006049540 9.152436e-29 1.379397e-26 17 16349714 16349930 217 - 1.896 1.199 -2.390
ENSG00000166582 E026 2037.153022 0.0017259911 5.005545e-01 6.367908e-01 17 16349931 16350029 99 - 3.244 3.195 -0.163
ENSG00000166582 E027 1674.773595 0.0115396765 1.058619e-02 3.017820e-02 17 16353027 16353480 454 - 3.247 3.084 -0.540
ENSG00000166582 E028 1.697294 0.0081117367 7.521699e-02 1.518794e-01 17 16353628 16353656 29 - 0.606 0.273 -1.798