ENSG00000166562

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000587834 ENSG00000166562 HEK293_OSMI2_2hA HEK293_TMG_2hB SEC11C protein_coding protein_coding 92.52296 57.52404 142.2547 5.961897 0.8532104 1.30609 79.704386 48.220879 128.671103 5.0563136 2.0482170 1.4157712 0.84271250 0.83803333 0.90446667 0.06643333 0.01089259 0.002640346 FALSE  
ENST00000588875 ENSG00000166562 HEK293_OSMI2_2hA HEK293_TMG_2hB SEC11C protein_coding protein_coding 92.52296 57.52404 142.2547 5.961897 0.8532104 1.30609 6.870578 4.169995 7.333702 0.7682481 0.8240926 0.8130063 0.08150417 0.07153333 0.05153333 -0.02000000 0.26065350 0.002640346 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000166562 E001 9.6228816 0.0355419226 1.039240e-02 0.0297263883 18 59139476 59139618 143 + 0.851 1.184 1.229
ENSG00000166562 E002 14.3958170 0.0258538967 3.256630e-02 0.0769352067 18 59139866 59139874 9 + 1.064 1.301 0.843
ENSG00000166562 E003 28.2629981 0.0008178239 6.611716e-04 0.0027565961 18 59139875 59139883 9 + 1.355 1.581 0.778
ENSG00000166562 E004 30.6632252 0.0018601422 6.433019e-04 0.0026919866 18 59139884 59139887 4 + 1.388 1.612 0.769
ENSG00000166562 E005 33.7383269 0.0006829915 1.114616e-03 0.0043526890 18 59139888 59139892 5 + 1.441 1.641 0.685
ENSG00000166562 E006 42.5168902 0.0006588155 1.744998e-02 0.0459330288 18 59139893 59139898 6 + 1.569 1.702 0.452
ENSG00000166562 E007 388.4250140 0.0006429343 7.734080e-02 0.1552198949 18 59139899 59140035 137 + 2.590 2.552 -0.126
ENSG00000166562 E008 1.4874889 0.0827346331 2.076232e-01 0.3356280633 18 59140036 59140051 16 + 0.279 0.524 1.376
ENSG00000166562 E009 0.7718584 0.0155786269 7.309096e-01 0.8226930312 18 59146983 59147294 312 + 0.224 0.288 0.474
ENSG00000166562 E010 1.2124595 0.1433898561 7.871293e-01 0.8636684978 18 59147295 59148012 718 + 0.327 0.379 0.306
ENSG00000166562 E011 292.3538025 0.0004739967 3.750539e-03 0.0124407482 18 59149513 59149524 12 + 2.477 2.410 -0.223
ENSG00000166562 E012 533.5178304 0.0001691100 3.588328e-03 0.0119777623 18 59149525 59149622 98 + 2.731 2.685 -0.151
ENSG00000166562 E013 635.2362177 0.0001218196 6.052375e-02 0.1275151104 18 59152536 59152612 77 + 2.800 2.776 -0.082
ENSG00000166562 E014 648.5476085 0.0001789667 1.671014e-02 0.0442988756 18 59152613 59152685 73 + 2.813 2.781 -0.107
ENSG00000166562 E015 8.8336045 0.0019859861 3.573736e-01 0.5017776748 18 59152686 59153361 676 + 1.010 0.906 -0.391
ENSG00000166562 E016 2.6162891 0.0059255182 8.187075e-01 0.8854404623 18 59155605 59155687 83 + 0.541 0.582 0.184
ENSG00000166562 E017 782.6511670 0.0006949674 2.330565e-01 0.3660504701 18 59155688 59155807 120 + 2.874 2.896 0.071
ENSG00000166562 E018 32.6412989 0.0226488672 1.185991e-01 0.2179393722 18 59155808 59157311 1504 + 1.564 1.426 -0.474
ENSG00000166562 E019 412.7400204 0.0003684012 5.518987e-02 0.1183164322 18 59157608 59157665 58 + 2.590 2.629 0.130
ENSG00000166562 E020 480.2222291 0.0004974361 9.960355e-05 0.0005200241 18 59158632 59158832 201 + 2.642 2.715 0.246