ENSG00000166526

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000299667 ENSG00000166526 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF3 protein_coding protein_coding 21.26209 18.79191 23.42901 1.019263 0.9849453 0.3180324 9.332232 6.7815666 10.8394448 1.10208942 0.5072599 0.6758049 0.43667500 0.35743333 0.46606667 0.10863333 0.37835811 0.001341054 FALSE TRUE
ENST00000412947 ENSG00000166526 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF3 protein_coding protein_coding 21.26209 18.79191 23.42901 1.019263 0.9849453 0.3180324 2.055430 3.8137288 0.8296755 0.46437665 0.5055113 -2.1870764 0.09878750 0.20623333 0.03386667 -0.17236667 0.00424747 0.001341054 FALSE TRUE
ENST00000424697 ENSG00000166526 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF3 protein_coding protein_coding 21.26209 18.79191 23.42901 1.019263 0.9849453 0.3180324 1.847432 2.9132453 1.8874891 0.69395888 0.3547651 -0.6234793 0.08965000 0.15410000 0.07963333 -0.07446667 0.18462800 0.001341054 FALSE TRUE
ENST00000428683 ENSG00000166526 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF3 protein_coding protein_coding 21.26209 18.79191 23.42901 1.019263 0.9849453 0.3180324 1.804765 1.0978054 2.0910288 0.08924604 0.2586117 0.9233914 0.08315833 0.05840000 0.08866667 0.03026667 0.10576717 0.001341054 FALSE FALSE
ENST00000487620 ENSG00000166526 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF3 protein_coding retained_intron 21.26209 18.79191 23.42901 1.019263 0.9849453 0.3180324 1.718396 0.6637328 2.0550379 0.28152954 0.1327518 1.6159197 0.07977083 0.03456667 0.08796667 0.05340000 0.07269363 0.001341054 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000166526 E001 0.9212829 0.0433385438 5.977955e-01 7.195126e-01 7 100057887 100057932 46 - 0.212 0.305 0.692
ENSG00000166526 E002 5.5992171 0.0029252127 3.820393e-01 5.262919e-01 7 100063705 100064032 328 - 0.757 0.869 0.439
ENSG00000166526 E003 30.7799919 0.0007861841 1.926944e-04 9.325918e-04 7 100064033 100064663 631 - 1.362 1.599 0.814
ENSG00000166526 E004 20.7076699 0.0062708897 1.818788e-04 8.859963e-04 7 100064664 100064912 249 - 1.143 1.461 1.112
ENSG00000166526 E005 1.8175762 0.0376820764 1.892646e-01 3.128107e-01 7 100069972 100069972 1 - 0.546 0.304 -1.310
ENSG00000166526 E006 2.9977810 0.0186927887 7.698747e-01 8.514184e-01 7 100069973 100069978 6 - 0.618 0.568 -0.221
ENSG00000166526 E007 4.0201276 0.0044003687 5.674290e-01 6.942325e-01 7 100069979 100069991 13 - 0.649 0.731 0.339
ENSG00000166526 E008 68.1532330 0.0006831365 6.136459e-09 7.880516e-08 7 100069992 100070176 185 - 1.694 1.950 0.862
ENSG00000166526 E009 268.0699642 0.0006021033 2.758371e-21 2.038711e-19 7 100070177 100070681 505 - 2.305 2.524 0.730
ENSG00000166526 E010 368.2499266 0.0001869317 7.320449e-10 1.113568e-08 7 100070682 100071266 585 - 2.510 2.619 0.361
ENSG00000166526 E011 398.4063394 0.0003840117 5.752343e-01 7.008949e-01 7 100071267 100071929 663 - 2.610 2.599 -0.036
ENSG00000166526 E012 144.7674707 0.0002963795 1.869557e-02 4.866608e-02 7 100071930 100072079 150 - 2.201 2.132 -0.231
ENSG00000166526 E013 104.7011375 0.0003090549 8.230072e-02 1.631418e-01 7 100072080 100072170 91 - 2.058 1.998 -0.200
ENSG00000166526 E014 74.6726779 0.0003919095 2.790643e-02 6.782677e-02 7 100072171 100072212 42 - 1.928 1.839 -0.300
ENSG00000166526 E015 117.3095865 0.0003092876 3.765151e-03 1.248287e-02 7 100075135 100075229 95 - 2.122 2.028 -0.315
ENSG00000166526 E016 60.2344077 0.0004596112 9.145023e-03 2.664520e-02 7 100075230 100075235 6 - 1.846 1.728 -0.398
ENSG00000166526 E017 67.9784626 0.0007655525 2.800277e-04 1.298696e-03 7 100075236 100075261 26 - 1.915 1.755 -0.538
ENSG00000166526 E018 11.8292336 0.0056297455 1.854535e-02 4.833216e-02 7 100075262 100075311 50 - 1.215 0.974 -0.872
ENSG00000166526 E019 6.8416973 0.0026356375 2.728583e-03 9.458424e-03 7 100075312 100075316 5 - 1.044 0.673 -1.442
ENSG00000166526 E020 16.7935760 0.0563495048 2.033347e-02 5.218390e-02 7 100075317 100075541 225 - 1.385 1.058 -1.160
ENSG00000166526 E021 100.5510407 0.0038267891 3.600981e-03 1.201386e-02 7 100075542 100075630 89 - 2.072 1.936 -0.456
ENSG00000166526 E022 6.5687922 0.0174691249 3.509347e-01 4.951259e-01 7 100077018 100077228 211 - 0.948 0.826 -0.466
ENSG00000166526 E023 9.9487200 0.0092196560 2.580829e-01 3.952804e-01 7 100077229 100077302 74 - 1.102 0.974 -0.467
ENSG00000166526 E024 112.8624290 0.0002592683 1.582341e-03 5.901096e-03 7 100077303 100077433 131 - 2.111 2.007 -0.348
ENSG00000166526 E025 5.3392787 0.0030793602 7.506492e-01 8.372529e-01 7 100077434 100077839 406 - 0.824 0.782 -0.165
ENSG00000166526 E026 8.9322863 0.0025071033 1.848988e-01 3.073594e-01 7 100078682 100079167 486 - 1.068 0.925 -0.531
ENSG00000166526 E027 60.2680058 0.0005350187 2.618966e-04 1.224289e-03 7 100079536 100079572 37 - 1.869 1.703 -0.561
ENSG00000166526 E028 79.1119129 0.0044112506 3.742080e-04 1.674364e-03 7 100079573 100079656 84 - 1.991 1.808 -0.614
ENSG00000166526 E029 62.3969922 0.0010372699 3.168127e-02 7.522525e-02 7 100081635 100081764 130 - 1.852 1.752 -0.337
ENSG00000166526 E030 23.2380117 0.0010272577 4.610924e-01 6.010801e-01 7 100082301 100082548 248 - 1.412 1.359 -0.184