ENSG00000166436

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000402157 ENSG00000166436 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM66 protein_coding nonsense_mediated_decay 1.858261 1.500329 1.846194 0.1927535 0.2347335 0.2974841 0.43191001 0.37220309 0.3811966 0.24735096 0.03996404 0.03355452 0.22545417 0.21690000 0.21313333 -0.003766667 0.89450692 0.04944957 FALSE TRUE
ENST00000525788 ENSG00000166436 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM66 protein_coding retained_intron 1.858261 1.500329 1.846194 0.1927535 0.2347335 0.2974841 0.02079362 0.00000000 0.1012874 0.00000000 0.06981408 3.47621846 0.01367500 0.00000000 0.05663333 0.056633333 0.31054409 0.04944957 FALSE TRUE
ENST00000529211 ENSG00000166436 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM66 protein_coding retained_intron 1.858261 1.500329 1.846194 0.1927535 0.2347335 0.2974841 0.09381620 0.02248615 0.1883106 0.02248615 0.09420629 2.60986501 0.05015417 0.01373333 0.09720000 0.083466667 0.45081855 0.04944957   FALSE
ENST00000530502 ENSG00000166436 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM66 protein_coding protein_coding 1.858261 1.500329 1.846194 0.1927535 0.2347335 0.2974841 0.22126270 0.22896266 0.0493446 0.03717430 0.04934460 -2.00959662 0.11148333 0.15513333 0.02136667 -0.133766667 0.04944957 0.04944957 FALSE FALSE
ENST00000644261 ENSG00000166436 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM66 protein_coding protein_coding 1.858261 1.500329 1.846194 0.1927535 0.2347335 0.2974841 0.20651337 0.08500565 0.3318746 0.04267084 0.17561657 1.84738200 0.11366667 0.05026667 0.17180000 0.121533333 0.74152994 0.04944957   FALSE
ENST00000646038 ENSG00000166436 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM66 protein_coding protein_coding 1.858261 1.500329 1.846194 0.1927535 0.2347335 0.2974841 0.79901708 0.77467789 0.7642865 0.12372111 0.04598974 -0.01923316 0.44443333 0.55356667 0.42310000 -0.130466667 0.71797534 0.04944957 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000166436 E001 0.1451727 0.042875191 4.847531e-01   11 8612037 8612039 3 - 0.123 0.000 -9.080
ENSG00000166436 E002 163.6889423 0.001050083 5.915493e-20 3.729359e-18 11 8612040 8615538 3499 - 2.068 2.299 0.773
ENSG00000166436 E003 76.7373129 0.008008480 8.510823e-02 1.675848e-01 11 8615539 8617568 2030 - 1.928 1.842 -0.290
ENSG00000166436 E004 11.0415482 0.020272470 5.890222e-01 7.121473e-01 11 8617569 8617763 195 - 1.096 1.035 -0.221
ENSG00000166436 E005 11.0916986 0.001646086 3.826512e-01 5.268515e-01 11 8617764 8618003 240 - 1.118 1.030 -0.320
ENSG00000166436 E006 0.2987644 0.029078516 1.982899e-01   11 8618722 8618749 28 - 0.219 0.000 -12.329
ENSG00000166436 E007 8.3966458 0.007764011 7.735254e-01 8.538703e-01 11 8618750 8618876 127 - 0.993 0.958 -0.132
ENSG00000166436 E008 8.5247765 0.013767026 6.267010e-01 7.426030e-01 11 8618877 8618968 92 - 0.948 1.002 0.202
ENSG00000166436 E009 1.0779977 0.063252411 6.235145e-02 1.306020e-01 11 8618969 8619284 316 - 0.472 0.122 -2.604
ENSG00000166436 E010 11.4626400 0.013681499 2.478557e-01 3.834086e-01 11 8619383 8619535 153 - 1.021 1.144 0.446
ENSG00000166436 E011 7.7599379 0.065004679 2.755987e-01 4.149289e-01 11 8620050 8620124 75 - 0.839 1.005 0.630
ENSG00000166436 E012 9.4825820 0.004781821 6.854793e-01 7.881984e-01 11 8620446 8620572 127 - 1.047 1.002 -0.167
ENSG00000166436 E013 11.7410000 0.001588134 2.830869e-01 4.231595e-01 11 8621032 8621237 206 - 1.159 1.055 -0.376
ENSG00000166436 E014 5.1443227 0.003834827 5.860693e-01 7.097048e-01 11 8621238 8621321 84 - 0.817 0.743 -0.298
ENSG00000166436 E015 10.7627714 0.009301049 4.204006e-01 5.636114e-01 11 8621645 8621819 175 - 1.107 1.017 -0.327
ENSG00000166436 E016 6.3943449 0.002670055 8.601486e-01 9.137886e-01 11 8622816 8622876 61 - 0.878 0.854 -0.093
ENSG00000166436 E017 9.8234652 0.002423146 4.295670e-01 5.722737e-01 11 8624359 8624551 193 - 1.072 0.988 -0.308
ENSG00000166436 E018 1.0351207 0.012871091 9.939207e-01 1.000000e+00 11 8624552 8624712 161 - 0.297 0.295 -0.017
ENSG00000166436 E019 14.8727158 0.001391581 1.104796e-01 2.062376e-01 11 8624713 8625228 516 - 1.264 1.124 -0.498
ENSG00000166436 E020 5.1672254 0.003354925 5.839390e-01 7.079487e-01 11 8638654 8638815 162 - 0.817 0.743 -0.297
ENSG00000166436 E021 11.0307672 0.001581622 2.181696e-01 3.482059e-01 11 8640227 8641152 926 - 1.139 1.016 -0.446
ENSG00000166436 E022 3.0063284 0.080371202 3.842115e-01 5.283814e-01 11 8643009 8643126 118 - 0.694 0.512 -0.807
ENSG00000166436 E023 0.0000000       11 8644330 8644429 100 -      
ENSG00000166436 E024 0.0000000       11 8645722 8645740 19 -      
ENSG00000166436 E025 6.0874958 0.034389007 2.065960e-02 5.286766e-02 11 8645741 8645887 147 - 1.007 0.658 -1.368
ENSG00000166436 E026 7.5613383 0.040963228 2.792844e-01 4.190096e-01 11 8646447 8646561 115 - 0.993 0.842 -0.574
ENSG00000166436 E027 6.6014459 0.132619429 3.191599e-01 4.622021e-01 11 8647970 8648080 111 - 0.948 0.787 -0.620
ENSG00000166436 E028 1.9457971 0.024179111 8.723121e-02 1.709425e-01 11 8648081 8648086 6 - 0.596 0.295 -1.597
ENSG00000166436 E029 4.6469906 0.003839506 2.543148e-01 3.909727e-01 11 8648416 8648548 133 - 0.817 0.659 -0.645
ENSG00000166436 E030 3.3623266 0.004645973 9.016948e-03 2.632020e-02 11 8649740 8649887 148 - 0.817 0.418 -1.785
ENSG00000166436 E031 3.0615876 0.043562170 3.453403e-03 1.159070e-02 11 8651800 8651903 104 - 0.817 0.295 -2.519
ENSG00000166436 E032 2.2467516 0.006876960 2.870740e-02 6.941860e-02 11 8654434 8654578 145 - 0.663 0.295 -1.891
ENSG00000166436 E033 0.3686942 0.027612208 9.962387e-01 1.000000e+00 11 8658737 8658836 100 - 0.123 0.122 -0.016
ENSG00000166436 E034 1.8456783 0.007799313 1.958009e-03 7.094556e-03 11 8663129 8663248 120 - 0.663 0.122 -3.477
ENSG00000166436 E035 4.0775624 0.072023283 4.970547e-01 6.336163e-01 11 8671786 8672016 231 - 0.746 0.635 -0.466
ENSG00000166436 E036 2.9014467 0.007984468 8.202701e-01 8.866038e-01 11 8672017 8672098 82 - 0.559 0.593 0.154
ENSG00000166436 E037 5.6788292 0.008988361 2.499363e-01 3.858382e-01 11 8672248 8672385 138 - 0.896 0.743 -0.602
ENSG00000166436 E038 4.1320967 0.004020838 7.430424e-04 3.054224e-03 11 8674806 8674883 78 - 0.914 0.418 -2.156
ENSG00000166436 E039 1.4749183 0.054400234 3.513275e-01 4.955436e-01 11 8678134 8678169 36 - 0.472 0.296 -1.011
ENSG00000166436 E040 9.0494721 0.001919235 1.409759e-01 2.493670e-01 11 8679620 8679814 195 - 1.084 0.926 -0.583
ENSG00000166436 E041 9.9093580 0.002788885 1.277019e-01 2.309581e-01 11 8679901 8680063 163 - 1.118 0.958 -0.585
ENSG00000166436 E042 7.1308150 0.002410563 8.942857e-01 9.364294e-01 11 8682601 8682694 94 - 0.896 0.909 0.049