ENSG00000166402

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000299506 ENSG00000166402 HEK293_OSMI2_2hA HEK293_TMG_2hB TUB protein_coding protein_coding 19.73867 17.22684 22.21848 1.470087 0.1132339 0.3669138 2.794681 0.0000000 7.680736 0.0000000 0.91108555 9.5869779 0.13708750 0.00000000 0.3459000 0.34590000 7.255790e-30 7.25579e-30 FALSE TRUE
MSTRG.5100.3 ENSG00000166402 HEK293_OSMI2_2hA HEK293_TMG_2hB TUB protein_coding   19.73867 17.22684 22.21848 1.470087 0.1132339 0.3669138 10.615797 9.7803118 8.450275 0.5645486 0.71671378 -0.2106502 0.54116250 0.57376667 0.3802333 -0.19353333 2.867792e-02 7.25579e-30 FALSE TRUE
MSTRG.5100.7 ENSG00000166402 HEK293_OSMI2_2hA HEK293_TMG_2hB TUB protein_coding   19.73867 17.22684 22.21848 1.470087 0.1132339 0.3669138 1.302285 1.3141239 2.059942 0.2332586 0.21095196 0.6445522 0.06504167 0.07873333 0.0926000 0.01386667 7.792892e-01 7.25579e-30 FALSE TRUE
MSTRG.5100.8 ENSG00000166402 HEK293_OSMI2_2hA HEK293_TMG_2hB TUB protein_coding   19.73867 17.22684 22.21848 1.470087 0.1132339 0.3669138 2.109958 0.7985191 3.611057 0.2491702 0.04477275 2.1630572 0.10371667 0.04640000 0.1625667 0.11616667 1.965885e-04 7.25579e-30 FALSE TRUE
MSTRG.5100.9 ENSG00000166402 HEK293_OSMI2_2hA HEK293_TMG_2hB TUB protein_coding   19.73867 17.22684 22.21848 1.470087 0.1132339 0.3669138 2.795435 5.2837908 0.000000 1.6321689 0.00000000 -9.0481574 0.14709167 0.29846667 0.0000000 -0.29846667 5.229704e-18 7.25579e-30 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000166402 E001 0.2934659 0.0286605588 8.775285e-01   11 8019244 8019358 115 + 0.092 0.160 0.915
ENSG00000166402 E002 0.0000000       11 8038633 8039028 396 +      
ENSG00000166402 E003 0.0000000       11 8039645 8039692 48 +      
ENSG00000166402 E004 1.0006785 0.0142190988 5.834579e-01 7.075784e-01 11 8080876 8081047 172 + 0.289 0.278 -0.082
ENSG00000166402 E005 0.9609246 0.0130912719 5.801331e-01 7.049588e-01 11 8081198 8081210 13 + 0.289 0.277 -0.083
ENSG00000166402 E006 2.9039945 0.0429247543 1.669320e-02 4.426113e-02 11 8081211 8081252 42 + 0.681 0.369 -1.503
ENSG00000166402 E007 3.3521980 0.0440308858 6.011387e-03 1.864133e-02 11 8081253 8081292 40 + 0.741 0.369 -1.751
ENSG00000166402 E008 11.2815664 0.0110322333 2.724837e-11 5.284187e-10 11 8081293 8081427 135 + 1.245 0.510 -2.892
ENSG00000166402 E009 10.0701320 0.0149486044 1.818036e-06 1.427476e-05 11 8081428 8081478 51 + 1.161 0.702 -1.744
ENSG00000166402 E010 22.4638351 0.0228622254 1.598698e-04 7.912753e-04 11 8081479 8081548 70 + 1.436 1.210 -0.790
ENSG00000166402 E011 28.4493756 0.0026279523 8.039425e-04 3.273055e-03 11 8089610 8089661 52 + 1.482 1.423 -0.204
ENSG00000166402 E012 59.7474461 0.0004276494 1.823213e-06 1.430977e-05 11 8090069 8090231 163 + 1.791 1.748 -0.146
ENSG00000166402 E013 28.8709414 0.0006440680 5.601104e-06 3.942472e-05 11 8094046 8094051 6 + 1.512 1.385 -0.438
ENSG00000166402 E014 72.7888733 0.0029744597 5.106200e-06 3.626989e-05 11 8094052 8094189 138 + 1.876 1.827 -0.163
ENSG00000166402 E015 75.8668911 0.0011314377 7.311252e-06 5.010834e-05 11 8095498 8095665 168 + 1.883 1.866 -0.056
ENSG00000166402 E016 78.2776436 0.0066820113 9.741060e-06 6.495195e-05 11 8096685 8096806 122 + 1.916 1.838 -0.264
ENSG00000166402 E017 110.7620852 0.0207453361 2.771203e-03 9.586869e-03 11 8097228 8097425 198 + 2.058 2.000 -0.192
ENSG00000166402 E018 95.2737920 0.0031159358 1.185434e-06 9.690903e-06 11 8097714 8097826 113 + 1.989 1.944 -0.150
ENSG00000166402 E019 102.1937243 0.0002951751 8.109947e-13 2.021320e-11 11 8098758 8098875 118 + 2.034 1.956 -0.260
ENSG00000166402 E020 95.9005292 0.0002787860 2.931140e-13 7.800193e-12 11 8100503 8100601 99 + 2.011 1.920 -0.305
ENSG00000166402 E021 133.4592060 0.0002994859 7.202764e-13 1.807340e-11 11 8100826 8100997 172 + 2.137 2.092 -0.153
ENSG00000166402 E022 51.3977188 0.0047475083 3.032534e-06 2.266379e-05 11 8100998 8101267 270 + 1.748 1.643 -0.357
ENSG00000166402 E023 86.9605904 0.0036593986 3.090610e-02 7.373320e-02 11 8101486 8101568 83 + 1.904 1.977 0.248
ENSG00000166402 E024 736.1362731 0.0028195179 1.643054e-03 6.098582e-03 11 8101569 8103494 1926 + 2.816 2.915 0.330
ENSG00000166402 E025 1630.4669163 0.0110234761 4.088235e-11 7.694256e-10 11 8103495 8106243 2749 + 3.022 3.387 1.213