ENSG00000166313

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000299402 ENSG00000166313 HEK293_OSMI2_2hA HEK293_TMG_2hB APBB1 protein_coding protein_coding 43.78728 80.70165 24.84291 1.205923 1.110454 -1.699362 27.321231 49.936454 15.1656089 1.753716 0.37097512 -1.7186279 0.63550833 0.61856667 0.612533333 -0.006033333 0.981254770 0.0001549362 FALSE  
ENST00000311051 ENSG00000166313 HEK293_OSMI2_2hA HEK293_TMG_2hB APBB1 protein_coding protein_coding 43.78728 80.70165 24.84291 1.205923 1.110454 -1.699362 4.158059 5.825211 3.4308996 1.419372 0.87943971 -0.7619991 0.09207917 0.07173333 0.135533333 0.063800000 0.296176075 0.0001549362 FALSE  
ENST00000524626 ENSG00000166313 HEK293_OSMI2_2hA HEK293_TMG_2hB APBB1 protein_coding retained_intron 43.78728 80.70165 24.84291 1.205923 1.110454 -1.699362 2.185002 7.504013 0.2220177 3.624490 0.04862742 -5.0172766 0.03295000 0.09380000 0.009133333 -0.084666667 0.009848522 0.0001549362 FALSE  
MSTRG.5070.14 ENSG00000166313 HEK293_OSMI2_2hA HEK293_TMG_2hB APBB1 protein_coding   43.78728 80.70165 24.84291 1.205923 1.110454 -1.699362 5.298428 11.367604 3.3005520 1.112997 0.29282464 -1.7810530 0.11970417 0.14093333 0.132666667 -0.008266667 0.903525337 0.0001549362 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000166313 E001 35.0782781 0.0006884611 9.111678e-02 1.768754e-01 11 6395125 6395142 18 - 1.342 1.468 0.436
ENSG00000166313 E002 50.0618504 0.0062817596 1.509148e-02 4.069291e-02 11 6395143 6395157 15 - 1.442 1.627 0.635
ENSG00000166313 E003 66.6768630 0.0151830159 1.294976e-02 3.579413e-02 11 6395158 6395162 5 - 1.540 1.751 0.719
ENSG00000166313 E004 160.6787245 0.0017411791 1.769247e-07 1.713329e-06 11 6395163 6395279 117 - 1.902 2.128 0.760
ENSG00000166313 E005 183.0711005 0.0013555501 4.823571e-06 3.447823e-05 11 6395280 6395303 24 - 2.000 2.179 0.598
ENSG00000166313 E006 418.2982522 0.0011550520 2.098269e-07 2.003481e-06 11 6395304 6395429 126 - 2.387 2.530 0.477
ENSG00000166313 E007 272.6072552 0.0008352887 7.702645e-06 5.252098e-05 11 6395430 6395467 38 - 2.205 2.343 0.461
ENSG00000166313 E008 601.9730693 0.0021437171 4.289444e-04 1.885916e-03 11 6395468 6395701 234 - 2.582 2.680 0.327
ENSG00000166313 E009 573.5832573 0.0007405545 1.454826e-02 3.947190e-02 11 6395786 6395962 177 - 2.600 2.651 0.169
ENSG00000166313 E010 510.0166061 0.0001536622 3.392334e-01 4.831469e-01 11 6396100 6396215 116 - 2.581 2.595 0.047
ENSG00000166313 E011 10.1541221 0.0039006506 1.103676e-01 2.060732e-01 11 6396216 6396574 359 - 1.095 0.903 -0.707
ENSG00000166313 E012 418.3996621 0.0001879562 8.481369e-01 9.057276e-01 11 6400989 6401051 63 - 2.508 2.507 -0.003
ENSG00000166313 E013 321.9540656 0.0004213822 6.405214e-01 7.537462e-01 11 6401052 6401072 21 - 2.409 2.392 -0.057
ENSG00000166313 E014 2.7688446 0.0058300290 3.447475e-01 4.888467e-01 11 6401073 6401073 1 - 0.621 0.453 -0.791
ENSG00000166313 E015 4.9465943 0.0038961884 1.480885e-02 4.006473e-02 11 6401074 6401176 103 - 0.936 0.584 -1.425
ENSG00000166313 E016 4.0806723 0.0669299976 5.769480e-05 3.200711e-04 11 6401177 6401344 168 - 1.071 0.372 -2.992
ENSG00000166313 E017 276.9907549 0.0005717556 4.867724e-01 6.244968e-01 11 6401345 6401346 2 - 2.350 2.325 -0.083
ENSG00000166313 E018 308.5196159 0.0006257050 5.270007e-01 6.601692e-01 11 6401347 6401364 18 - 2.394 2.372 -0.074
ENSG00000166313 E019 416.4412850 0.0004948557 7.314498e-01 8.230978e-01 11 6401365 6401429 65 - 2.503 2.506 0.011
ENSG00000166313 E020 7.3362649 0.0023663372 3.585609e-04 1.613115e-03 11 6401430 6401573 144 - 1.137 0.699 -1.665
ENSG00000166313 E021 262.2189531 0.0002234451 2.783974e-01 4.180893e-01 11 6401574 6401586 13 - 2.284 2.309 0.084
ENSG00000166313 E022 434.9813602 0.0002003362 3.528912e-01 4.971346e-01 11 6401587 6401688 102 - 2.511 2.526 0.051
ENSG00000166313 E023 8.2650870 0.0284989316 1.202095e-05 7.840436e-05 11 6401689 6401976 288 - 1.259 0.674 -2.204
ENSG00000166313 E024 5.0918556 0.0137602197 9.282010e-04 3.713412e-03 11 6401977 6401982 6 - 1.022 0.546 -1.923
ENSG00000166313 E025 462.0997160 0.0001622694 5.167630e-01 6.512937e-01 11 6402082 6402209 128 - 2.540 2.549 0.028
ENSG00000166313 E026 2.0982523 0.0117405792 7.444472e-01 8.327845e-01 11 6402210 6402575 366 - 0.463 0.398 -0.343
ENSG00000166313 E027 525.4080244 0.0002443846 8.728068e-02 1.710093e-01 11 6402576 6402725 150 - 2.635 2.596 -0.131
ENSG00000166313 E028 1.4706388 0.0588985282 6.524313e-03 1.998628e-02 11 6402726 6402784 59 - 0.682 0.177 -2.921
ENSG00000166313 E029 347.3551179 0.0001901320 2.514216e-03 8.806870e-03 11 6403145 6403208 64 - 2.485 2.409 -0.254
ENSG00000166313 E030 291.3981626 0.0001608143 1.385847e-03 5.260755e-03 11 6403319 6403362 44 - 2.418 2.332 -0.287
ENSG00000166313 E031 288.9747531 0.0001828949 2.770993e-02 6.744216e-02 11 6403363 6403404 42 - 2.394 2.332 -0.207
ENSG00000166313 E032 291.3665032 0.0010238105 1.550970e-01 2.685359e-01 11 6403488 6403544 57 - 2.387 2.339 -0.158
ENSG00000166313 E033 271.3292862 0.0021632927 3.247133e-01 4.681295e-01 11 6403647 6403717 71 - 2.350 2.310 -0.133
ENSG00000166313 E034 356.5395464 0.0032559338 3.101215e-02 7.393951e-02 11 6403718 6403822 105 - 2.503 2.421 -0.273
ENSG00000166313 E035 7.8417208 0.0023495140 1.185339e-01 2.178407e-01 11 6403823 6403837 15 - 0.995 0.791 -0.781
ENSG00000166313 E036 0.0000000       11 6403838 6403937 100 -      
ENSG00000166313 E037 0.0000000       11 6403938 6404058 121 -      
ENSG00000166313 E038 0.5503986 0.0205171575 6.046492e-01 7.251029e-01 11 6404607 6404744 138 - 0.214 0.125 -0.926
ENSG00000166313 E039 0.0000000       11 6404745 6404784 40 -      
ENSG00000166313 E040 0.0000000       11 6404785 6404898 114 -      
ENSG00000166313 E041 0.1482932 0.0412266120 1.000000e+00   11 6405133 6405386 254 - 0.000 0.067 7.333
ENSG00000166313 E042 0.6966155 0.0167265942 8.445036e-01 9.031995e-01 11 6405387 6405660 274 - 0.214 0.176 -0.343
ENSG00000166313 E043 930.9478895 0.0024050358 2.079222e-04 9.978021e-04 11 6410627 6411361 735 - 2.931 2.833 -0.325
ENSG00000166313 E044 170.4880703 0.0114338686 2.426131e-01 3.772258e-01 11 6418985 6419099 115 - 2.173 2.103 -0.236
ENSG00000166313 E045 33.1283524 0.0547033837 5.055726e-02 1.101468e-01 11 6419346 6419511 166 - 1.612 1.358 -0.873