ENSG00000166311

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000342245 ENSG00000166311 HEK293_OSMI2_2hA HEK293_TMG_2hB SMPD1 protein_coding protein_coding 13.04126 18.93743 7.393216 0.8793673 0.3672564 -1.355778 7.1112895 9.117433 4.6572021 0.3522756 0.1134531 -0.9676512 0.55486250 0.48273333 0.63173333 0.149000000 0.007222221 0.007222221 FALSE TRUE
ENST00000526280 ENSG00000166311 HEK293_OSMI2_2hA HEK293_TMG_2hB SMPD1 protein_coding protein_coding 13.04126 18.93743 7.393216 0.8793673 0.3672564 -1.355778 0.7156024 1.004580 0.5791972 0.2012307 0.2655885 -0.7840597 0.05123333 0.05400000 0.08180000 0.027800000 0.921992653 0.007222221 FALSE TRUE
ENST00000531336 ENSG00000166311 HEK293_OSMI2_2hA HEK293_TMG_2hB SMPD1 protein_coding retained_intron 13.04126 18.93743 7.393216 0.8793673 0.3672564 -1.355778 2.2666579 3.730880 0.6693770 0.3227385 0.2927246 -2.4610933 0.16573750 0.19843333 0.09023333 -0.108200000 0.209542629 0.007222221 FALSE FALSE
MSTRG.5069.1 ENSG00000166311 HEK293_OSMI2_2hA HEK293_TMG_2hB SMPD1 protein_coding   13.04126 18.93743 7.393216 0.8793673 0.3672564 -1.355778 1.7508299 2.821745 1.0729585 0.6079378 0.3257089 -1.3867134 0.13092500 0.14806667 0.14223333 -0.005833333 0.978354898 0.007222221 FALSE TRUE
MSTRG.5069.3 ENSG00000166311 HEK293_OSMI2_2hA HEK293_TMG_2hB SMPD1 protein_coding   13.04126 18.93743 7.393216 0.8793673 0.3672564 -1.355778 0.3515225 1.633532 0.0000000 0.8380234 0.0000000 -7.3606559 0.02067500 0.08446667 0.00000000 -0.084466667 0.245969376 0.007222221 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000166311 E001 7.014113 0.0340654968 0.6394415251 0.752840257 11 6390440 6390445 6 + 0.784 0.863 0.308
ENSG00000166311 E002 11.992042 0.0086987755 0.5776925768 0.702920647 11 6390446 6390472 27 + 1.086 1.035 -0.188
ENSG00000166311 E003 12.137215 0.0049929125 0.4504553605 0.591544666 11 6390473 6390473 1 + 1.104 1.034 -0.255
ENSG00000166311 E004 13.020833 0.0136921274 0.4329757763 0.575426044 11 6390474 6390474 1 + 1.137 1.060 -0.279
ENSG00000166311 E005 30.451139 0.0102660270 0.2115771056 0.340352625 11 6390475 6390502 28 + 1.499 1.408 -0.313
ENSG00000166311 E006 47.537385 0.0079466467 0.5831858371 0.707350311 11 6390503 6390581 79 + 1.636 1.613 -0.077
ENSG00000166311 E007 47.131111 0.0039970387 0.9075826881 0.945342080 11 6390582 6390639 58 + 1.610 1.615 0.020
ENSG00000166311 E008 78.955666 0.0005083762 0.0242703572 0.060369817 11 6390640 6390813 174 + 1.902 1.818 -0.285
ENSG00000166311 E009 62.837818 0.0095620471 0.0413912756 0.093608053 11 6390814 6390916 103 + 1.827 1.711 -0.394
ENSG00000166311 E010 27.787969 0.0155308437 0.3194204992 0.462508735 11 6391384 6391386 3 + 1.455 1.379 -0.261
ENSG00000166311 E011 55.027094 0.0023023467 0.3522408309 0.496515133 11 6391387 6391503 117 + 1.715 1.676 -0.132
ENSG00000166311 E012 75.573078 0.0003405594 0.0963510496 0.184898526 11 6391504 6391789 286 + 1.865 1.804 -0.206
ENSG00000166311 E013 65.701997 0.0004994312 0.4972595657 0.633808405 11 6391790 6391876 87 + 1.778 1.757 -0.071
ENSG00000166311 E014 87.289151 0.0003563089 0.9361591819 0.963835342 11 6391877 6392005 129 + 1.877 1.885 0.028
ENSG00000166311 E015 94.834318 0.0003073642 0.2685834781 0.407066490 11 6392006 6392156 151 + 1.942 1.910 -0.107
ENSG00000166311 E016 5.888628 0.0028432002 0.3945345949 0.538357453 11 6392157 6392196 40 + 0.852 0.747 -0.415
ENSG00000166311 E017 79.497811 0.0007647832 0.9230698994 0.955495215 11 6393216 6393292 77 + 1.834 1.841 0.025
ENSG00000166311 E018 101.581424 0.0034711778 0.7073008625 0.805254904 11 6393293 6393387 95 + 1.921 1.953 0.106
ENSG00000166311 E019 3.795532 0.0452298620 0.9973571758 1.000000000 11 6393518 6393616 99 + 0.608 0.620 0.053
ENSG00000166311 E020 93.084049 0.0003770910 0.6973050334 0.797459444 11 6393617 6393693 77 + 1.913 1.909 -0.014
ENSG00000166311 E021 112.144021 0.0007871941 0.3504418592 0.494611061 11 6393896 6394041 146 + 1.952 2.000 0.161
ENSG00000166311 E022 17.612986 0.0078691908 0.1449233466 0.254738602 11 6394042 6394177 136 + 1.086 1.247 0.574
ENSG00000166311 E023 10.490394 0.0022809403 0.1575075212 0.271800329 11 6394178 6394197 20 + 0.852 1.033 0.681
ENSG00000166311 E024 323.537336 0.0048479571 0.0007103595 0.002935957 11 6394198 6394998 801 + 2.346 2.480 0.447