ENSG00000166261

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000336139 ENSG00000166261 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF202 protein_coding protein_coding 11.10407 8.075108 14.40405 0.7887643 0.6389307 0.8341365 2.1599749 1.6825032 2.195530 0.62776036 0.4160546 0.3819668 0.2041792 0.20930000 0.15446667 -0.05483333 8.483802e-01 1.499127e-06 FALSE TRUE
ENST00000525391 ENSG00000166261 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF202 protein_coding processed_transcript 11.10407 8.075108 14.40405 0.7887643 0.6389307 0.8341365 1.1855342 1.4297115 1.065385 0.23524718 0.2834688 -0.4209261 0.1134708 0.17466667 0.07260000 -0.10206667 8.860680e-03 1.499127e-06   FALSE
ENST00000526252 ENSG00000166261 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF202 protein_coding protein_coding 11.10407 8.075108 14.40405 0.7887643 0.6389307 0.8341365 0.1560247 0.5633683 0.000000 0.24713046 0.0000000 -5.8413902 0.0183875 0.06733333 0.00000000 -0.06733333 1.499127e-06 1.499127e-06   FALSE
ENST00000529691 ENSG00000166261 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF202 protein_coding protein_coding 11.10407 8.075108 14.40405 0.7887643 0.6389307 0.8341365 3.6168817 2.9281949 4.999365 0.58996078 0.1746370 0.7696977 0.3261750 0.36730000 0.34740000 -0.01990000 9.619583e-01 1.499127e-06 FALSE TRUE
MSTRG.6491.13 ENSG00000166261 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF202 protein_coding   11.10407 8.075108 14.40405 0.7887643 0.6389307 0.8341365 0.5115001 0.2257730 1.182172 0.01906787 0.1148151 2.3381216 0.0440500 0.02823333 0.08233333 0.05410000 1.996381e-03 1.499127e-06 TRUE FALSE
MSTRG.6491.8 ENSG00000166261 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF202 protein_coding   11.10407 8.075108 14.40405 0.7887643 0.6389307 0.8341365 2.4218425 0.5538596 3.645076 0.38749912 0.4321337 2.6964936 0.2027625 0.06626667 0.25166667 0.18540000 2.154031e-01 1.499127e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000166261 E001 0.1451727 0.0439674883 8.407980e-01   11 123721709 123721750 42 - 0.096 0.000 -8.045
ENSG00000166261 E002 1.1414830 0.0853932716 3.091589e-01 4.514285e-01 11 123723914 123724176 263 - 0.241 0.433 1.205
ENSG00000166261 E003 36.2676264 0.0181118302 9.438763e-03 2.737935e-02 11 123724177 123724697 521 - 1.457 1.694 0.806
ENSG00000166261 E004 23.3444513 0.0266540698 5.544410e-02 1.187478e-01 11 123724698 123724779 82 - 1.280 1.512 0.805
ENSG00000166261 E005 14.7095062 0.0352960907 2.995083e-02 7.186220e-02 11 123724780 123724788 9 - 1.056 1.353 1.056
ENSG00000166261 E006 35.3409073 0.0204731391 5.033842e-03 1.602363e-02 11 123724789 123724819 31 - 1.430 1.700 0.922
ENSG00000166261 E007 38.0432333 0.0053502862 8.567924e-05 4.548217e-04 11 123724820 123724841 22 - 1.465 1.730 0.902
ENSG00000166261 E008 88.8823485 0.0002998595 8.851489e-09 1.101766e-07 11 123724842 123724995 154 - 1.851 2.068 0.729
ENSG00000166261 E009 182.0394322 0.0004613053 8.410509e-09 1.051089e-07 11 123724996 123725543 548 - 2.188 2.346 0.525
ENSG00000166261 E010 305.2540217 0.0003173354 5.480581e-01 6.779671e-01 11 123725544 123726546 1003 - 2.476 2.492 0.056
ENSG00000166261 E011 40.7741901 0.0026936067 6.149249e-02 1.291483e-01 11 123726547 123726566 20 - 1.658 1.547 -0.377
ENSG00000166261 E012 51.1418298 0.0015108683 3.410477e-01 4.849725e-01 11 123726567 123726618 52 - 1.732 1.686 -0.155
ENSG00000166261 E013 43.9261506 0.0007487361 9.886776e-01 9.969713e-01 11 123726619 123726642 24 - 1.646 1.650 0.014
ENSG00000166261 E014 40.3273012 0.0005697318 5.298506e-01 6.625826e-01 11 123726643 123726670 28 - 1.597 1.637 0.136
ENSG00000166261 E015 48.1944508 0.0004473659 1.696356e-01 2.877277e-01 11 123726671 123726712 42 - 1.715 1.650 -0.222
ENSG00000166261 E016 45.7663911 0.0038648659 6.628575e-01 7.710789e-01 11 123726713 123726749 37 - 1.676 1.653 -0.078
ENSG00000166261 E017 59.9324407 0.0008417018 7.775053e-03 2.321487e-02 11 123726750 123726856 107 - 1.828 1.705 -0.416
ENSG00000166261 E018 81.1089993 0.0147183721 2.445826e-01 3.795498e-01 11 123726857 123726991 135 - 1.942 1.858 -0.282
ENSG00000166261 E019 62.5395010 0.0004381901 1.799574e-02 4.712342e-02 11 123727476 123727595 120 - 1.837 1.733 -0.351
ENSG00000166261 E020 70.9777037 0.0004063926 1.271014e-01 2.300993e-01 11 123728133 123728262 130 - 1.877 1.817 -0.203
ENSG00000166261 E021 47.3149915 0.0050142618 6.816514e-01 7.852935e-01 11 123729126 123729214 89 - 1.692 1.672 -0.067
ENSG00000166261 E022 67.4915542 0.0016039528 8.606449e-03 2.530444e-02 11 123729615 123729825 211 - 1.879 1.759 -0.404
ENSG00000166261 E023 16.6030583 0.0714245722 9.769259e-01 9.895878e-01 11 123730487 123730490 4 - 1.239 1.227 -0.042
ENSG00000166261 E024 27.8353711 0.0051320361 3.603361e-01 5.046543e-01 11 123730491 123730509 19 - 1.480 1.412 -0.232
ENSG00000166261 E025 72.7499717 0.0003279698 5.027914e-03 1.600879e-02 11 123730510 123730751 242 - 1.908 1.794 -0.383
ENSG00000166261 E026 38.8971360 0.0005145073 7.439106e-03 2.236002e-02 11 123730752 123730807 56 - 1.653 1.503 -0.513
ENSG00000166261 E027 38.7836334 0.0005827122 2.000631e-05 1.240990e-04 11 123730808 123730857 50 - 1.683 1.433 -0.854
ENSG00000166261 E028 27.5290054 0.0006777216 1.900264e-03 6.915747e-03 11 123730858 123730859 2 - 1.527 1.316 -0.728
ENSG00000166261 E029 42.1978011 0.0005647549 3.083314e-04 1.413387e-03 11 123730860 123730923 64 - 1.703 1.503 -0.681
ENSG00000166261 E030 37.9752139 0.0103231129 1.553622e-03 5.809662e-03 11 123730924 123730985 62 - 1.670 1.419 -0.857
ENSG00000166261 E031 15.4350134 0.0012258153 4.539656e-05 2.584433e-04 11 123738624 123738910 287 - 1.037 1.390 1.251
ENSG00000166261 E032 6.4055334 0.0025595681 1.769411e-01 2.972575e-01 11 123739434 123739543 110 - 0.792 0.961 0.648
ENSG00000166261 E033 25.4032775 0.0041600992 9.860594e-01 9.952954e-01 11 123740117 123740127 11 - 1.415 1.419 0.015
ENSG00000166261 E034 31.9450009 0.0071349761 8.742557e-01 9.231497e-01 11 123740128 123740189 62 - 1.508 1.519 0.040
ENSG00000166261 E035 13.4690812 0.0045224002 8.890751e-01 9.330672e-01 11 123740190 123740192 3 - 1.149 1.167 0.063
ENSG00000166261 E036 21.2094327 0.0010133552 6.520546e-01 7.627886e-01 11 123740193 123740232 40 - 1.328 1.367 0.135
ENSG00000166261 E037 9.6422621 0.0178262800 6.704224e-02 1.384526e-01 11 123740233 123740392 160 - 1.102 0.870 -0.858
ENSG00000166261 E038 8.2736656 0.0215532809 3.208676e-01 4.640437e-01 11 123740393 123740416 24 - 1.007 0.872 -0.504
ENSG00000166261 E039 36.5468981 0.0006505965 5.553019e-01 6.841911e-01 11 123740417 123740536 120 - 1.586 1.557 -0.099
ENSG00000166261 E040 23.9938633 0.0007603627 3.635831e-01 5.079987e-01 11 123741549 123741675 127 - 1.419 1.359 -0.207