ENSG00000166260

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000299335 ENSG00000166260 HEK293_OSMI2_2hA HEK293_TMG_2hB COX11 protein_coding protein_coding 39.88433 22.52811 61.75256 2.393073 0.9184412 1.454366 2.261840 0.7180754 3.783994 0.14023186 0.25726309 2.3815576 0.05685833 0.03263333 0.06136667 0.02873333 5.883681e-02 1.106574e-05 FALSE TRUE
ENST00000571584 ENSG00000166260 HEK293_OSMI2_2hA HEK293_TMG_2hB COX11 protein_coding protein_coding 39.88433 22.52811 61.75256 2.393073 0.9184412 1.454366 5.725194 2.1705683 9.176002 0.02514813 1.15271240 2.0747329 0.13416667 0.09820000 0.14830000 0.05010000 1.590827e-01 1.106574e-05 FALSE TRUE
ENST00000572088 ENSG00000166260 HEK293_OSMI2_2hA HEK293_TMG_2hB COX11 protein_coding retained_intron 39.88433 22.52811 61.75256 2.393073 0.9184412 1.454366 1.515505 1.1543386 1.238256 0.11146989 0.09620792 0.1004030 0.05752083 0.05130000 0.02003333 -0.03126667 1.106574e-05 1.106574e-05 FALSE TRUE
ENST00000572558 ENSG00000166260 HEK293_OSMI2_2hA HEK293_TMG_2hB COX11 protein_coding nonsense_mediated_decay 39.88433 22.52811 61.75256 2.393073 0.9184412 1.454366 4.347560 3.8878547 6.532888 0.23940892 0.33664936 0.7472473 0.12777500 0.17480000 0.10570000 -0.06910000 1.867077e-03 1.106574e-05 TRUE TRUE
ENST00000574989 ENSG00000166260 HEK293_OSMI2_2hA HEK293_TMG_2hB COX11 protein_coding processed_transcript 39.88433 22.52811 61.75256 2.393073 0.9184412 1.454366 2.460016 0.7068139 3.590440 0.70681393 1.37522699 2.3285026 0.06905833 0.03483333 0.05776667 0.02293333 2.785592e-01 1.106574e-05   FALSE
MSTRG.14707.9 ENSG00000166260 HEK293_OSMI2_2hA HEK293_TMG_2hB COX11 protein_coding   39.88433 22.52811 61.75256 2.393073 0.9184412 1.454366 21.356415 11.7970777 33.970190 2.29777652 1.01855568 1.5250420 0.48477917 0.51460000 0.55060000 0.03600000 8.157145e-01 1.106574e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000166260 E001 0.4375944 0.0266967722 3.235861e-01 4.668910e-01 17 54951590 54951901 312 - 0.217 0.001 -8.976
ENSG00000166260 E002 0.2934659 0.0281313232 5.409335e-01   17 54951902 54951905 4 - 0.085 0.173 1.180
ENSG00000166260 E003 0.5149111 0.0202718719 1.984871e-01 3.243086e-01 17 54951906 54951908 3 - 0.085 0.297 2.183
ENSG00000166260 E004 2.7979909 0.0057460556 1.691420e-02 4.474465e-02 17 54951909 54951934 26 - 0.400 0.771 1.697
ENSG00000166260 E005 26.9052074 0.0034679150 5.705416e-17 2.526587e-15 17 54951935 54952112 178 - 1.117 1.716 2.075
ENSG00000166260 E006 56.5985742 0.0008016303 4.918239e-22 3.938062e-20 17 54952113 54953660 1548 - 1.529 1.984 1.540
ENSG00000166260 E007 18.3230962 0.0011116383 2.376816e-08 2.730463e-07 17 54953661 54953759 99 - 1.064 1.503 1.544
ENSG00000166260 E008 77.9442916 0.0013606648 1.449673e-04 7.253227e-04 17 54953760 54955149 1390 - 1.815 1.974 0.532
ENSG00000166260 E009 11.9292284 0.0014350404 6.355143e-01 7.498009e-01 17 54955304 54955352 49 - 1.080 1.122 0.154
ENSG00000166260 E010 38.4488860 0.0319941826 4.404179e-01 5.820977e-01 17 54959201 54959466 266 - 1.556 1.615 0.201
ENSG00000166260 E011 38.0987535 0.0013972567 3.117925e-05 1.847901e-04 17 54960422 54961118 697 - 1.650 1.363 -0.984
ENSG00000166260 E012 79.7190540 0.0021286821 1.815251e-07 1.753935e-06 17 54961119 54961312 194 - 1.796 2.020 0.754
ENSG00000166260 E013 33.5456529 0.0009936431 7.066851e-05 3.833339e-04 17 54961313 54961326 14 - 1.430 1.668 0.813
ENSG00000166260 E014 1033.4469383 0.0043337025 4.968955e-01 6.334688e-01 17 54961327 54962902 1576 - 3.003 2.979 -0.083
ENSG00000166260 E015 143.4991965 0.0002227147 1.560814e-05 9.920205e-05 17 54962903 54962915 13 - 2.187 2.042 -0.485
ENSG00000166260 E016 29.4903132 0.0007070244 6.392505e-01 7.526809e-01 17 54962916 54963305 390 - 1.476 1.439 -0.129
ENSG00000166260 E017 355.9089774 0.0001958481 1.868876e-01 3.098199e-01 17 54963306 54963431 126 - 2.546 2.515 -0.105
ENSG00000166260 E018 408.4272774 0.0002731591 3.157482e-03 1.072941e-02 17 54964697 54964852 156 - 2.616 2.555 -0.204
ENSG00000166260 E019 5.4296893 0.2597597462 7.493087e-01 8.363015e-01 17 54965577 54965659 83 - 0.821 0.707 -0.459
ENSG00000166260 E020 0.0000000       17 54965660 54965660 1 -      
ENSG00000166260 E021 539.9392307 0.0014498659 4.778515e-03 1.531328e-02 17 54968281 54968703 423 - 2.738 2.666 -0.240