ENSG00000166257

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000299333 ENSG00000166257 HEK293_OSMI2_2hA HEK293_TMG_2hB SCN3B protein_coding protein_coding 1.417881 1.045029 1.755095 0.05000587 0.0006741363 0.742463 0.94330778 0.856821660 0.7648287 0.008244462 0.17467364 -0.1618579 0.67784167 0.82353333 0.43583333 -0.38770000 0.01755977 0.01755977 FALSE TRUE
ENST00000392770 ENSG00000166257 HEK293_OSMI2_2hA HEK293_TMG_2hB SCN3B protein_coding protein_coding 1.417881 1.045029 1.755095 0.05000587 0.0006741363 0.742463 0.17398168 0.131338216 0.2958726 0.055167944 0.07551708 1.1137795 0.12116250 0.12116667 0.16853333 0.04736667 0.79747022 0.01755977 FALSE TRUE
ENST00000530277 ENSG00000166257 HEK293_OSMI2_2hA HEK293_TMG_2hB SCN3B protein_coding protein_coding 1.417881 1.045029 1.755095 0.05000587 0.0006741363 0.742463 0.07487742 0.013504638 0.1963807 0.006794421 0.01837760 3.1342909 0.04729583 0.01343333 0.11190000 0.09846667 0.04651720 0.01755977 FALSE TRUE
ENST00000657191 ENSG00000166257 HEK293_OSMI2_2hA HEK293_TMG_2hB SCN3B protein_coding protein_coding 1.417881 1.045029 1.755095 0.05000587 0.0006741363 0.742463 0.09438663 0.000000000 0.3080522 0.000000000 0.17691122 4.9911916 0.06474167 0.00000000 0.17546667 0.17546667 0.28682491 0.01755977 FALSE TRUE
ENST00000667790 ENSG00000166257 HEK293_OSMI2_2hA HEK293_TMG_2hB SCN3B protein_coding nonsense_mediated_decay 1.417881 1.045029 1.755095 0.05000587 0.0006741363 0.742463 0.06444816 0.008236521 0.1071020 0.004649588 0.03390427 2.6828639 0.04623333 0.00800000 0.06103333 0.05303333 0.06783739 0.01755977 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000166257 E001 0.2214452 0.0383117807 3.499334e-01   11 123629187 123629187 1 - 0.000 0.143 9.996
ENSG00000166257 E002 0.2214452 0.0383117807 3.499334e-01   11 123629188 123629188 1 - 0.000 0.143 12.165
ENSG00000166257 E003 1.0339748 0.0648995233 2.406485e-01 3.749251e-01 11 123629189 123629200 12 - 0.188 0.409 1.523
ENSG00000166257 E004 17.3251064 0.0042595432 1.396398e-06 1.123279e-05 11 123629201 123629450 250 - 1.033 1.444 1.456
ENSG00000166257 E005 22.4155969 0.0059864965 3.467452e-09 4.651596e-08 11 123629451 123629625 175 - 1.094 1.565 1.648
ENSG00000166257 E006 57.0350264 0.0027065665 1.918732e-04 9.291160e-04 11 123629626 123630612 987 - 1.674 1.850 0.595
ENSG00000166257 E007 23.9706137 0.0015619907 8.455770e-02 1.666861e-01 11 123630613 123631213 601 - 1.441 1.328 -0.393
ENSG00000166257 E008 57.0826134 0.0007057809 1.169611e-03 4.537678e-03 11 123631214 123633111 1898 - 1.816 1.683 -0.448
ENSG00000166257 E009 24.3359117 0.0102148852 3.082301e-01 4.504923e-01 11 123633112 123633776 665 - 1.429 1.354 -0.259
ENSG00000166257 E010 2.5862019 0.0058608712 3.700501e-02 8.548120e-02 11 123633777 123634120 344 - 0.682 0.336 -1.702
ENSG00000166257 E011 7.7772906 0.0023690604 4.876965e-02 1.069752e-01 11 123634121 123634206 86 - 1.033 0.810 -0.842
ENSG00000166257 E012 0.0000000       11 123638123 123638185 63 -      
ENSG00000166257 E013 10.7698654 0.0017178484 1.372407e-03 5.216349e-03 11 123638186 123638324 139 - 1.188 0.860 -1.207
ENSG00000166257 E014 1.4403492 0.0147308265 2.321260e-01 3.649577e-01 11 123638325 123638776 452 - 0.463 0.251 -1.285
ENSG00000166257 E015 0.1515154 0.0422801950 6.659973e-01   11 123638777 123638829 53 - 0.104 0.000 -12.391
ENSG00000166257 E016 1.4154708 0.0151203222 2.309181e-01 3.635745e-01 11 123638830 123640766 1937 - 0.463 0.250 -1.287
ENSG00000166257 E017 0.3289534 0.0286946792 8.009187e-01   11 123640767 123641124 358 - 0.104 0.143 0.521
ENSG00000166257 E018 2.5904683 0.0058982642 3.699642e-02 8.546870e-02 11 123641342 123641817 476 - 0.682 0.336 -1.702
ENSG00000166257 E019 10.7472908 0.0215199533 6.987301e-03 2.119110e-02 11 123642446 123642671 226 - 1.188 0.860 -1.205
ENSG00000166257 E020 5.4761236 0.0146125103 1.411918e-01 2.496690e-01 11 123645587 123645750 164 - 0.891 0.690 -0.800
ENSG00000166257 E021 5.0438292 0.0172224774 5.366402e-02 1.156637e-01 11 123653747 123653826 80 - 0.891 0.614 -1.125
ENSG00000166257 E022 2.9141216 0.0054179387 4.842510e-01 6.222608e-01 11 123653827 123654225 399 - 0.629 0.524 -0.478
ENSG00000166257 E023 10.7852078 0.0288385661 6.734821e-01 7.791627e-01 11 123654226 123654624 399 - 1.033 1.095 0.227
ENSG00000166257 E024 0.2924217 0.0290785164 3.116952e-01   11 123654890 123655006 117 - 0.188 0.000 -13.353
ENSG00000166257 E025 0.0000000       11 123655108 123655244 137 -