ENSG00000166226

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000299300 ENSG00000166226 HEK293_OSMI2_2hA HEK293_TMG_2hB CCT2 protein_coding protein_coding 244.3296 126.7343 369.0618 22.15444 8.307 1.54198 196.94135 88.054699 299.04510 8.0683707 8.328986 1.763776 0.7840500 0.71370000 0.81006667 0.09636667 3.310604e-01 6.360903e-31 FALSE TRUE
MSTRG.7652.16 ENSG00000166226 HEK293_OSMI2_2hA HEK293_TMG_2hB CCT2 protein_coding   244.3296 126.7343 369.0618 22.15444 8.307 1.54198 10.43787 29.953612 0.00000 13.3444638 0.000000 -11.548996 0.0786000 0.21670000 0.00000000 -0.21670000 6.360903e-31 6.360903e-31 FALSE TRUE
MSTRG.7652.2 ENSG00000166226 HEK293_OSMI2_2hA HEK293_TMG_2hB CCT2 protein_coding   244.3296 126.7343 369.0618 22.15444 8.307 1.54198 14.85379 4.180505 30.71704 0.3103915 1.745235 2.874313 0.0563875 0.03513333 0.08333333 0.04820000 2.666127e-03 6.360903e-31 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000166226 E001 0.7385489 0.0482680601 1.576338e-01 2.719711e-01 12 69585412 69585414 3 + 0.299 0.000 -11.537
ENSG00000166226 E002 1.4769841 0.0089225364 2.050075e-02 5.254706e-02 12 69585415 69585425 11 + 0.475 0.000 -12.505
ENSG00000166226 E003 49.6388285 0.0006147467 1.470841e-09 2.112398e-08 12 69585426 69585458 33 + 1.753 1.398 -1.212
ENSG00000166226 E004 50.0827656 0.0006075399 8.528690e-10 1.279790e-08 12 69585459 69585459 1 + 1.757 1.398 -1.227
ENSG00000166226 E005 203.0437487 0.0005316187 2.725247e-19 1.606357e-17 12 69585460 69585471 12 + 2.343 2.079 -0.883
ENSG00000166226 E006 754.2714329 0.0015636258 8.693195e-15 2.886766e-13 12 69585472 69585524 53 + 2.893 2.717 -0.585
ENSG00000166226 E007 0.4460135 0.0359886716 3.696463e-01 5.140452e-01 12 69585666 69585750 85 + 0.203 0.000 -10.769
ENSG00000166226 E008 5.7739351 0.0224893210 1.697645e-02 4.488428e-02 12 69585751 69586009 259 + 0.889 0.497 -1.657
ENSG00000166226 E009 1013.4967146 0.0003797300 2.079987e-23 1.925059e-21 12 69586270 69586344 75 + 3.013 2.876 -0.454
ENSG00000166226 E010 1004.0529489 0.0007923333 8.252743e-13 2.054477e-11 12 69586753 69586818 66 + 3.003 2.887 -0.385
ENSG00000166226 E011 3.4018545 0.0254489039 2.362787e-01 3.698586e-01 12 69586819 69587147 329 + 0.679 0.494 -0.831
ENSG00000166226 E012 1411.8513264 0.0015524524 2.691060e-09 3.687085e-08 12 69587505 69587616 112 + 3.151 3.035 -0.386
ENSG00000166226 E013 3.8514049 0.0042139373 1.253123e-02 3.480894e-02 12 69587617 69587778 162 + 0.746 0.315 -2.097
ENSG00000166226 E014 1289.3255996 0.0013491982 3.784111e-10 6.059408e-09 12 69587930 69588006 77 + 3.112 2.995 -0.389
ENSG00000166226 E015 9.1354815 0.0018150814 3.740642e-02 8.623395e-02 12 69588007 69588149 143 + 1.039 0.802 -0.897
ENSG00000166226 E016 1480.4349290 0.0024619231 1.552300e-06 1.236597e-05 12 69588150 69588262 113 + 3.170 3.056 -0.380
ENSG00000166226 E017 18.2498621 0.0009595665 3.319108e-05 1.952537e-04 12 69588263 69588436 174 + 1.343 0.954 -1.396
ENSG00000166226 E018 35.6151873 0.0084957384 9.409473e-04 3.757402e-03 12 69589162 69589484 323 + 1.597 1.338 -0.889
ENSG00000166226 E019 1358.9441556 0.0006951963 7.694689e-11 1.383051e-09 12 69589485 69589578 94 + 3.128 3.038 -0.301
ENSG00000166226 E020 1439.8292633 0.0015599169 3.598073e-03 1.200564e-02 12 69589579 69589687 109 + 3.141 3.091 -0.168
ENSG00000166226 E021 5.5924191 0.0050200297 1.959496e-01 3.211551e-01 12 69589688 69589751 64 + 0.842 0.675 -0.676
ENSG00000166226 E022 2.3405316 0.1682820455 9.050504e-02 1.759277e-01 12 69590812 69590847 36 + 0.598 0.184 -2.487
ENSG00000166226 E023 1267.4616581 0.0042218835 5.620564e-01 6.897483e-01 12 69592059 69592159 101 + 3.074 3.061 -0.044
ENSG00000166226 E024 2.6249221 0.0853469869 7.515948e-01 8.379869e-01 12 69592160 69592313 154 + 0.503 0.569 0.306
ENSG00000166226 E025 7.9572894 0.0020929779 5.704857e-02 1.215466e-01 12 69592537 69592975 439 + 0.988 0.763 -0.865
ENSG00000166226 E026 1382.4690954 0.0022186533 1.004978e-01 1.912065e-01 12 69592976 69593103 128 + 3.092 3.142 0.165
ENSG00000166226 E027 624.4969643 0.0008887680 2.695468e-18 1.407520e-16 12 69593510 69593537 28 + 2.695 2.892 0.657
ENSG00000166226 E028 1082.5331999 0.0002434606 3.429388e-12 7.713253e-11 12 69593538 69593613 76 + 2.966 3.081 0.383
ENSG00000166226 E029 1665.7545935 0.0000854671 5.027172e-09 6.559109e-08 12 69597156 69597275 120 + 3.166 3.247 0.272
ENSG00000166226 E030 1858.9947609 0.0003030660 6.231957e-08 6.589783e-07 12 69597638 69597766 129 + 3.211 3.297 0.286
ENSG00000166226 E031 1816.5573306 0.0018859244 3.689607e-02 8.526703e-02 12 69597968 69598071 104 + 3.205 3.274 0.228
ENSG00000166226 E032 2043.2495185 0.0043952237 5.086916e-02 1.107231e-01 12 69598322 69598421 100 + 3.249 3.335 0.284
ENSG00000166226 E033 24.7359174 0.0079735158 2.227572e-04 1.060932e-03 12 69598862 69598989 128 + 1.457 1.123 -1.171
ENSG00000166226 E034 14.0088485 0.0012838799 3.078479e-01 4.500849e-01 12 69599714 69599862 149 + 1.111 1.230 0.424
ENSG00000166226 E035 2157.6097767 0.0057063255 4.630066e-03 1.490285e-02 12 69599863 69600004 142 + 3.258 3.385 0.424
ENSG00000166226 E036 1478.0869290 0.0040707034 8.503792e-09 1.061976e-07 12 69601295 69601574 280 + 3.062 3.270 0.689