ENSG00000166224

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373202 ENSG00000166224 HEK293_OSMI2_2hA HEK293_TMG_2hB SGPL1 protein_coding protein_coding 17.03673 14.73266 19.64407 1.876063 0.1628115 0.4148309 12.0087932 10.0330981 11.766043 1.2973622 0.7816490 0.2296505 0.70677917 0.682900000 0.59950000 -0.08340000 0.46999160 0.001505845 FALSE  
MSTRG.4123.2 ENSG00000166224 HEK293_OSMI2_2hA HEK293_TMG_2hB SGPL1 protein_coding   17.03673 14.73266 19.64407 1.876063 0.1628115 0.4148309 0.6134947 0.1274223 1.556910 0.0640285 0.4043646 3.5112337 0.03341667 0.009533333 0.07933333 0.06980000 0.02465236 0.001505845 FALSE  
MSTRG.4123.3 ENSG00000166224 HEK293_OSMI2_2hA HEK293_TMG_2hB SGPL1 protein_coding   17.03673 14.73266 19.64407 1.876063 0.1628115 0.4148309 1.9337343 2.8319883 1.906128 0.2502475 0.5768281 -0.5687067 0.11718333 0.196333333 0.09690000 -0.09943333 0.10826631 0.001505845 FALSE  
MSTRG.4123.4 ENSG00000166224 HEK293_OSMI2_2hA HEK293_TMG_2hB SGPL1 protein_coding   17.03673 14.73266 19.64407 1.876063 0.1628115 0.4148309 0.4012620 0.1584422 1.456046 0.1146806 0.3236155 3.1216054 0.02160000 0.009533333 0.07406667 0.06453333 0.01236876 0.001505845 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000166224 E001 0.1817044 0.0399964088 4.325594e-01   10 70815391 70815432 42 + 0.000 0.150 22.624
ENSG00000166224 E002 0.3268771 0.0296168762 9.411512e-01   10 70815579 70815905 327 + 0.099 0.150 0.678
ENSG00000166224 E003 0.6955713 0.0171635366 9.081441e-01 9.456824e-01 10 70815906 70815918 13 + 0.180 0.261 0.679
ENSG00000166224 E004 2.5671842 0.0257051942 4.769291e-01 6.155367e-01 10 70815919 70815924 6 + 0.553 0.541 -0.057
ENSG00000166224 E005 7.1282644 0.0084981992 1.390141e-01 2.467355e-01 10 70815925 70815947 23 + 0.927 0.880 -0.180
ENSG00000166224 E006 13.2895926 0.0149098106 1.549895e-03 5.797476e-03 10 70815948 70815960 13 + 1.229 1.020 -0.751
ENSG00000166224 E007 59.2003986 0.0143606475 1.144305e-03 4.452079e-03 10 70815961 70816118 158 + 1.815 1.715 -0.337
ENSG00000166224 E008 35.7115371 0.0006946711 1.170643e-05 7.658233e-05 10 70816119 70816126 8 + 1.606 1.498 -0.371
ENSG00000166224 E009 2.5348197 0.0229890218 5.536263e-02 1.186149e-01 10 70816127 70816157 31 + 0.638 0.422 -1.028
ENSG00000166224 E010 63.6728896 0.0038310106 5.930401e-05 3.279899e-04 10 70816811 70816880 70 + 1.835 1.776 -0.201
ENSG00000166224 E011 5.3706241 0.0554721173 3.994115e-01 5.431656e-01 10 70820184 70820484 301 + 0.663 0.927 1.050
ENSG00000166224 E012 42.6540837 0.0024291493 2.616693e-04 1.223377e-03 10 70844473 70844475 3 + 1.666 1.607 -0.200
ENSG00000166224 E013 55.5973026 0.0119742803 6.040525e-03 1.871673e-02 10 70844476 70844496 21 + 1.768 1.730 -0.131
ENSG00000166224 E014 103.7747515 0.0137837642 1.475121e-03 5.556582e-03 10 70844497 70844638 142 + 2.041 1.985 -0.189
ENSG00000166224 E015 76.8918601 0.0167795220 4.763373e-03 1.527070e-02 10 70851143 70851210 68 + 1.912 1.857 -0.183
ENSG00000166224 E016 0.0000000       10 70854706 70854707 2 +      
ENSG00000166224 E017 106.1449949 0.0070783489 1.113546e-05 7.319843e-05 10 70854708 70854855 148 + 2.061 1.981 -0.266
ENSG00000166224 E018 4.2417804 0.0037068419 8.115760e-03 2.407658e-02 10 70857185 70857602 418 + 0.806 0.540 -1.130
ENSG00000166224 E019 1.4038175 0.0095972129 2.155560e-02 5.475741e-02 10 70857603 70857613 11 + 0.486 0.150 -2.322
ENSG00000166224 E020 93.3260906 0.0033877082 7.447221e-07 6.359781e-06 10 70857614 70857690 77 + 2.005 1.931 -0.246
ENSG00000166224 E021 114.9659053 0.0002791122 1.295439e-09 1.880734e-08 10 70859371 70859499 129 + 2.085 2.040 -0.153
ENSG00000166224 E022 0.4804688 0.0211149897 6.406175e-01 7.538313e-01 10 70859500 70859605 106 + 0.180 0.150 -0.323
ENSG00000166224 E023 0.8856962 0.0137058617 4.916536e-01 6.289340e-01 10 70860393 70860486 94 + 0.307 0.260 -0.325
ENSG00000166224 E024 0.2944980 0.3753078299 3.414101e-01   10 70866274 70866705 432 + 0.180 0.000 -22.551
ENSG00000166224 E025 94.5593539 0.0003062017 5.737432e-07 5.018882e-06 10 70868345 70868433 89 + 1.991 1.963 -0.094
ENSG00000166224 E026 2.0702691 0.0073460146 5.300662e-01 6.627519e-01 10 70869186 70869326 141 + 0.486 0.485 -0.001
ENSG00000166224 E027 1.9250964 0.0079784483 7.025105e-01 8.013325e-01 10 70869327 70869424 98 + 0.447 0.485 0.191
ENSG00000166224 E028 90.8568244 0.0003388482 1.347602e-07 1.335386e-06 10 70869792 70869897 106 + 1.979 1.935 -0.145
ENSG00000166224 E029 1.4694955 0.0115879595 1.215404e-02 3.389987e-02 10 70869898 70870026 129 + 0.521 0.150 -2.493
ENSG00000166224 E030 96.8923920 0.0073190131 1.013666e-03 4.005973e-03 10 70871048 70871146 99 + 2.002 1.966 -0.121
ENSG00000166224 E031 115.3968654 0.0014093232 7.679768e-04 3.143031e-03 10 70871837 70871986 150 + 2.051 2.079 0.092
ENSG00000166224 E032 146.0827404 0.0016115929 2.884459e-04 1.332875e-03 10 70873351 70873589 239 + 2.153 2.180 0.090
ENSG00000166224 E033 137.5728436 0.0058428024 1.343931e-02 3.693925e-02 10 70875402 70875548 147 + 2.125 2.153 0.094
ENSG00000166224 E034 127.1936192 0.0002991737 9.781162e-03 2.822304e-02 10 70876541 70876661 121 + 2.073 2.146 0.245
ENSG00000166224 E035 1588.9610062 0.0106922462 3.125644e-11 5.998216e-10 10 70877195 70881184 3990 + 3.026 3.353 1.086