ENSG00000166206

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000299267 ENSG00000166206 HEK293_OSMI2_2hA HEK293_TMG_2hB GABRB3 protein_coding protein_coding 8.987966 5.929552 17.94541 1.010296 1.022368 1.595993 1.39508760 0.1010670 2.2350181 0.0531694 0.3585216 4.337225 0.14410417 0.02053333 0.12546667 0.10493333 0.01365802 0.01365802 FALSE TRUE
ENST00000311550 ENSG00000166206 HEK293_OSMI2_2hA HEK293_TMG_2hB GABRB3 protein_coding protein_coding 8.987966 5.929552 17.94541 1.010296 1.022368 1.595993 2.49479748 1.3946491 4.5595878 0.2461291 0.2376887 1.701854 0.31163333 0.24050000 0.25720000 0.01670000 0.90352534 0.01365802 FALSE TRUE
ENST00000545868 ENSG00000166206 HEK293_OSMI2_2hA HEK293_TMG_2hB GABRB3 protein_coding protein_coding 8.987966 5.929552 17.94541 1.010296 1.022368 1.595993 0.66512430 0.0000000 1.2495955 0.0000000 0.6253096 6.976817 0.07086250 0.00000000 0.06673333 0.06673333 0.31497943 0.01365802 FALSE TRUE
ENST00000554722 ENSG00000166206 HEK293_OSMI2_2hA HEK293_TMG_2hB GABRB3 protein_coding processed_transcript 8.987966 5.929552 17.94541 1.010296 1.022368 1.595993 0.67649204 1.0644761 0.4496449 0.5049109 0.2098767 -1.225042 0.11207083 0.20886667 0.02403333 -0.18483333 0.09145175 0.01365802 FALSE FALSE
ENST00000628124 ENSG00000166206 HEK293_OSMI2_2hA HEK293_TMG_2hB GABRB3 protein_coding protein_coding 8.987966 5.929552 17.94541 1.010296 1.022368 1.595993 0.17629809 0.5434739 0.0000000 0.5434739 0.0000000 -5.790443 0.03489583 0.10966667 0.00000000 -0.10966667 0.64983089 0.01365802 FALSE TRUE
ENST00000636512 ENSG00000166206 HEK293_OSMI2_2hA HEK293_TMG_2hB GABRB3 protein_coding processed_transcript 8.987966 5.929552 17.94541 1.010296 1.022368 1.595993 0.06777977 0.5422381 0.0000000 0.5422381 0.0000000 -5.787219 0.00852500 0.06820000 0.00000000 -0.06820000 0.61567049 0.01365802   FALSE
MSTRG.10325.24 ENSG00000166206 HEK293_OSMI2_2hA HEK293_TMG_2hB GABRB3 protein_coding   8.987966 5.929552 17.94541 1.010296 1.022368 1.595993 2.75757512 1.8509601 8.3556893 1.1170101 0.4272205 2.168437 0.23107917 0.27740000 0.46630000 0.18890000 0.69800784 0.01365802 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000166206 E001 0.0000000       15 26543546 26543548 3 -      
ENSG00000166206 E002 0.0000000       15 26543549 26543551 3 -      
ENSG00000166206 E003 5.7256506 0.0029726939 1.512469e-06 1.208387e-05 15 26543552 26543664 113 - 0.519 1.135 2.456
ENSG00000166206 E004 30.7917795 0.0007945171 5.889943e-10 9.120746e-09 15 26543665 26543843 179 - 1.318 1.713 1.354
ENSG00000166206 E005 116.0884997 0.0047859841 9.971772e-06 6.629430e-05 15 26543844 26544784 941 - 1.962 2.168 0.690
ENSG00000166206 E006 9.7377492 0.0018404774 6.833502e-01 7.865651e-01 15 26544785 26544797 13 - 0.985 1.038 0.196
ENSG00000166206 E007 184.8647813 0.0021130676 2.473269e-01 3.827956e-01 15 26544798 26546443 1646 - 2.220 2.264 0.148
ENSG00000166206 E008 101.5307684 0.0002915665 2.008141e-04 9.672190e-04 15 26546444 26547188 745 - 2.012 1.874 -0.463
ENSG00000166206 E009 32.7904194 0.0162441955 8.037814e-01 8.751529e-01 15 26547189 26547253 65 - 1.486 1.502 0.054
ENSG00000166206 E010 61.8975855 0.0086145848 7.250231e-01 8.183644e-01 15 26547254 26547632 379 - 1.767 1.741 -0.090
ENSG00000166206 E011 35.5515555 0.0006283243 1.914890e-01 3.156006e-01 15 26547633 26547792 160 - 1.549 1.472 -0.265
ENSG00000166206 E012 68.6242007 0.0017824585 2.172015e-01 3.470076e-01 15 26547793 26548058 266 - 1.823 1.769 -0.183
ENSG00000166206 E013 35.2935390 0.0006110543 7.194197e-01 8.142566e-01 15 26548059 26548134 76 - 1.532 1.518 -0.050
ENSG00000166206 E014 0.1472490 0.0434715395 1.000000e+00   15 26550071 26550114 44 - 0.076 0.000 -11.892
ENSG00000166206 E015 0.0000000       15 26553383 26553520 138 -      
ENSG00000166206 E016 50.0485062 0.0005139567 3.485843e-01 4.928191e-01 15 26560932 26561068 137 - 1.686 1.643 -0.145
ENSG00000166206 E017 36.5297709 0.0009048491 5.335129e-01 6.657038e-01 15 26561069 26561122 54 - 1.549 1.518 -0.108
ENSG00000166206 E018 38.6215981 0.0005845600 4.799771e-01 6.183163e-01 15 26561123 26561176 54 - 1.574 1.539 -0.121
ENSG00000166206 E019 45.9621873 0.0005456192 3.588723e-01 5.032404e-01 15 26567581 26567664 84 - 1.648 1.603 -0.152
ENSG00000166206 E020 33.2045834 0.0006625807 2.120838e-01 3.409969e-01 15 26567665 26567733 69 - 1.522 1.447 -0.259
ENSG00000166206 E021 0.0000000       15 26569312 26569342 31 -      
ENSG00000166206 E022 45.4882013 0.0185090517 2.988950e-01 4.403718e-01 15 26580319 26580456 138 - 1.656 1.563 -0.314
ENSG00000166206 E023 0.0000000       15 26580457 26580671 215 -      
ENSG00000166206 E024 0.8114855 0.3031193839 5.062276e-01 6.418869e-01 15 26581147 26581210 64 - 0.198 0.323 0.941
ENSG00000166206 E025 35.3500086 0.0212826755 9.405057e-02 1.814586e-01 15 26583332 26583414 83 - 1.564 1.402 -0.554
ENSG00000166206 E026 0.0000000       15 26590214 26590268 55 -      
ENSG00000166206 E027 3.2473298 0.0055031285 8.165857e-01 8.839630e-01 15 26611858 26615296 3439 - 0.589 0.634 0.196
ENSG00000166206 E028 0.4439371 0.0215638442 4.142649e-01 5.576645e-01 15 26615297 26615421 125 - 0.198 0.000 -13.502
ENSG00000166206 E029 0.5954526 0.0182707295 2.645485e-01 4.025113e-01 15 26615422 26615717 296 - 0.248 0.000 -13.902
ENSG00000166206 E030 0.0000000       15 26615774 26615777 4 -      
ENSG00000166206 E031 0.1515154 0.0430779314 1.000000e+00   15 26615778 26616060 283 - 0.076 0.000 -11.894
ENSG00000166206 E032 48.5300421 0.0018468475 1.239509e-01 2.256031e-01 15 26621314 26621534 221 - 1.680 1.597 -0.283
ENSG00000166206 E033 0.1451727 0.0433480671 1.000000e+00   15 26624208 26624631 424 - 0.076 0.000 -11.892
ENSG00000166206 E034 0.1482932 0.0411597534 1.650937e-01   15 26624765 26624985 221 - 0.000 0.190 13.421
ENSG00000166206 E035 0.4804688 0.0222388191 7.734648e-01 8.538432e-01 15 26625432 26625534 103 - 0.141 0.191 0.519
ENSG00000166206 E036 2.8658323 0.1062675888 4.906134e-02 1.074872e-01 15 26628977 26629178 202 - 0.404 0.779 1.709
ENSG00000166206 E037 0.0000000       15 26642433 26642528 96 -      
ENSG00000166206 E038 0.0000000       15 26666389 26666671 283 -      
ENSG00000166206 E039 0.0000000       15 26716614 26716765 152 -      
ENSG00000166206 E040 0.9922594 0.0133382157 6.982670e-01 7.982656e-01 15 26749935 26750149 215 - 0.248 0.323 0.521
ENSG00000166206 E041 0.4439371 0.0215638442 4.142649e-01 5.576645e-01 15 26750150 26750150 1 - 0.198 0.000 -13.502
ENSG00000166206 E042 0.0000000       15 26767152 26767236 85 -      
ENSG00000166206 E043 3.2398648 0.0050143926 2.541584e-02 6.273719e-02 15 26771819 26771957 139 - 0.466 0.813 1.519
ENSG00000166206 E044 0.3634088 0.5145390311 9.582962e-02   15 26771999 26772401 403 - 0.000 0.325 13.322
ENSG00000166206 E045 25.2063225 0.0007993253 7.556434e-02 1.524184e-01 15 26772402 26772469 68 - 1.415 1.283 -0.459
ENSG00000166206 E046 33.6498397 0.0006367194 1.502474e-01 2.620167e-01 15 26772681 26772772 92 - 1.527 1.438 -0.306
ENSG00000166206 E047 5.8648650 0.0027887616 9.095324e-01 9.465455e-01 15 26772883 26773076 194 - 0.792 0.814 0.087
ENSG00000166206 E048 24.4105768 0.0008081944 6.914663e-01 7.929361e-01 15 26773645 26773793 149 - 1.374 1.352 -0.079
ENSG00000166206 E049 0.0000000       15 26773943 26774003 61 -      
ENSG00000166206 E050 0.0000000       15 26789849 26790300 452 -      
ENSG00000166206 E051 0.0000000       15 26796005 26796092 88 -      
ENSG00000166206 E052 0.0000000       15 26798387 26798446 60 -      
ENSG00000166206 E053 0.0000000       15 26816367 26816414 48 -      
ENSG00000166206 E054 0.0000000       15 26939237 26939539 303 -