ENSG00000166200

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000299259 ENSG00000166200 HEK293_OSMI2_2hA HEK293_TMG_2hB COPS2 protein_coding protein_coding 35.90644 6.860339 64.2699 0.08903264 2.438703 3.225915 22.426552 5.4705585 40.937375 0.07856442 2.8685114 2.901376 0.68050000 0.79766667 0.63546667 -0.1622000 0.0006449247 0.0006449247 FALSE TRUE
ENST00000388901 ENSG00000166200 HEK293_OSMI2_2hA HEK293_TMG_2hB COPS2 protein_coding protein_coding 35.90644 6.860339 64.2699 0.08903264 2.438703 3.225915 2.530114 0.6801491 4.821599 0.12591409 0.2516936 2.807521 0.07634167 0.09936667 0.07496667 -0.0244000 0.4586141334 0.0006449247 FALSE TRUE
ENST00000558843 ENSG00000166200 HEK293_OSMI2_2hA HEK293_TMG_2hB COPS2 protein_coding protein_coding 35.90644 6.860339 64.2699 0.08903264 2.438703 3.225915 7.380977 0.4906636 15.755059 0.24549688 1.8724847 4.976745 0.15461667 0.07103333 0.24360000 0.1725667 0.2899965902 0.0006449247 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000166200 E001 1.7607818 0.0389413443 0.0082307738 0.0243689426 15 49106068 49106320 253 - 0.229 0.747 2.726
ENSG00000166200 E002 0.6934950 0.0836907365 0.0666449250 0.1378063622 15 49119045 49119167 123 - 0.090 0.454 3.000
ENSG00000166200 E003 296.7300888 0.0088914963 0.1466732093 0.2571611595 15 49122727 49127349 4623 - 2.290 2.403 0.378
ENSG00000166200 E004 140.9250763 0.0178117732 0.0026949985 0.0093589606 15 49127350 49127535 186 - 1.941 2.204 0.882
ENSG00000166200 E005 169.8097992 0.0186556924 0.0030787160 0.0104971566 15 49127536 49127658 123 - 2.023 2.279 0.859
ENSG00000166200 E006 423.4625830 0.0018991626 0.0001204509 0.0006160486 15 49127659 49128094 436 - 2.438 2.584 0.484
ENSG00000166200 E007 125.8098527 0.0013642576 0.8414766722 0.9011249431 15 49128702 49128760 59 - 1.930 1.971 0.139
ENSG00000166200 E008 173.2759077 0.0002356692 0.5633596494 0.6908505325 15 49129477 49129559 83 - 2.065 2.118 0.179
ENSG00000166200 E009 226.3801631 0.0002420117 0.6424682093 0.7552407685 15 49130719 49130816 98 - 2.186 2.201 0.050
ENSG00000166200 E010 196.6378459 0.0001748759 0.0774768441 0.1554106166 15 49133759 49133811 53 - 2.132 2.096 -0.120
ENSG00000166200 E011 239.4651070 0.0001815629 0.0051543314 0.0163492051 15 49133930 49134032 103 - 2.220 2.153 -0.224
ENSG00000166200 E012 170.5187239 0.0003468812 0.0912680485 0.1771054259 15 49134033 49134082 50 - 2.070 2.031 -0.131
ENSG00000166200 E013 132.9532676 0.0002498713 0.0169645692 0.0448578671 15 49134083 49134108 26 - 1.970 1.887 -0.278
ENSG00000166200 E014 0.2987644 0.0275648281 1.0000000000   15 49134135 49134339 205 - 0.090 0.000 -7.936
ENSG00000166200 E015 243.2653537 0.0001764366 0.1025936672 0.1944578537 15 49134340 49134514 175 - 2.222 2.198 -0.081
ENSG00000166200 E016 166.5719602 0.0004372429 0.4070545107 0.5506737878 15 49137150 49137227 78 - 2.056 2.053 -0.012
ENSG00000166200 E017 166.2447592 0.0008557370 0.0123915447 0.0344755109 15 49137348 49137422 75 - 2.065 1.984 -0.270
ENSG00000166200 E018 101.0295884 0.0037524681 0.0094829388 0.0274952831 15 49137423 49137437 15 - 1.856 1.719 -0.463
ENSG00000166200 E019 40.2208010 0.0005431160 0.0862694198 0.1694301907 15 49137438 49137458 21 - 1.463 1.344 -0.412
ENSG00000166200 E020 0.5891098 0.0182673995 1.0000000000 1.0000000000 15 49137459 49137459 1 - 0.165 0.000 -8.936
ENSG00000166200 E021 0.9704895 0.0850225513 0.7231854569 0.8170738872 15 49139258 49139527 270 - 0.198 0.284 0.673
ENSG00000166200 E022 186.2354534 0.0055167748 0.2944021292 0.4355066933 15 49139528 49139653 126 - 2.106 2.080 -0.086
ENSG00000166200 E023 201.1957998 0.0045427195 0.1430991821 0.2522457479 15 49144227 49144304 78 - 2.142 2.098 -0.147
ENSG00000166200 E024 222.9087293 0.0002636818 0.0016120383 0.0059993285 15 49144965 49145078 114 - 2.192 2.106 -0.287
ENSG00000166200 E025 149.5928144 0.0007938996 0.0193134024 0.0500125226 15 49155525 49155661 137 - 2.019 1.941 -0.261