ENSG00000166181

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000378852 ENSG00000166181 HEK293_OSMI2_2hA HEK293_TMG_2hB API5 protein_coding protein_coding 63.42315 26.67259 107.0111 2.008502 3.285424 2.003924 21.171832 8.58507690 34.69407797 1.79699457 2.79261159 2.013523 0.33303750 0.315666667 0.32323333 0.007566667 9.656748e-01 3.986344e-28 FALSE TRUE
ENST00000455725 ENSG00000166181 HEK293_OSMI2_2hA HEK293_TMG_2hB API5 protein_coding protein_coding 63.42315 26.67259 107.0111 2.008502 3.285424 2.003924 3.139787 0.18774718 7.32694054 0.04312786 0.54319184 5.213450 0.03906667 0.006933333 0.06826667 0.061333333 1.201808e-18 3.986344e-28 FALSE TRUE
ENST00000531273 ENSG00000166181 HEK293_OSMI2_2hA HEK293_TMG_2hB API5 protein_coding protein_coding 63.42315 26.67259 107.0111 2.008502 3.285424 2.003924 24.210007 8.88004032 38.75024795 1.22085443 1.29077746 2.124316 0.39003333 0.344266667 0.36233333 0.018066667 9.181862e-01 3.986344e-28 FALSE TRUE
ENST00000534695 ENSG00000166181 HEK293_OSMI2_2hA HEK293_TMG_2hB API5 protein_coding protein_coding 63.42315 26.67259 107.0111 2.008502 3.285424 2.003924 1.968647 6.86340644 0.03259553 2.33324211 0.03259553 -7.334179 0.07704583 0.247900000 0.00030000 -0.247600000 1.458458e-11 3.986344e-28 FALSE TRUE
MSTRG.5398.2 ENSG00000166181 HEK293_OSMI2_2hA HEK293_TMG_2hB API5 protein_coding   63.42315 26.67259 107.0111 2.008502 3.285424 2.003924 3.596957 0.07845518 9.56392919 0.03923258 0.41007514 6.758021 0.03884167 0.003066667 0.08946667 0.086400000 3.986344e-28 3.986344e-28 FALSE TRUE
MSTRG.5398.3 ENSG00000166181 HEK293_OSMI2_2hA HEK293_TMG_2hB API5 protein_coding   63.42315 26.67259 107.0111 2.008502 3.285424 2.003924 5.610239 0.00000000 11.43881484 0.00000000 1.36876989 10.160983 0.05335000 0.000000000 0.10790000 0.107900000 1.011390e-21 3.986344e-28 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000166181 E001 0.1515154 0.0429387741 1.000000e+00   11 43311963 43311966 4 + 0.056 0.000 -8.034
ENSG00000166181 E002 0.4439371 0.0215779730 6.638419e-01 7.718118e-01 11 43311967 43311967 1 + 0.150 0.000 -9.587
ENSG00000166181 E003 2.0586053 0.0085265391 2.152639e-01 3.447330e-01 11 43311968 43311977 10 + 0.445 0.248 -1.208
ENSG00000166181 E004 10.3556186 0.0017034898 2.386333e-01 3.725606e-01 11 43311978 43311988 11 + 0.952 0.900 -0.195
ENSG00000166181 E005 17.4178373 0.0010388628 3.154323e-02 7.496513e-02 11 43311989 43311995 7 + 1.172 1.043 -0.465
ENSG00000166181 E006 20.0548295 0.0009234356 9.835944e-03 2.836124e-02 11 43311996 43311997 2 + 1.235 1.072 -0.583
ENSG00000166181 E007 29.3277738 0.0006822875 1.280802e-03 4.912917e-03 11 43311998 43312002 5 + 1.393 1.216 -0.620
ENSG00000166181 E008 202.3235652 0.0098366863 1.176898e-03 4.563050e-03 11 43312003 43312095 93 + 2.203 2.126 -0.255
ENSG00000166181 E009 310.7554355 0.0026762751 2.224185e-10 3.693918e-09 11 43312096 43312196 101 + 2.395 2.273 -0.407
ENSG00000166181 E010 17.4073365 0.0009793695 4.641393e-07 4.132622e-06 11 43318421 43318482 62 + 1.218 0.611 -2.328
ENSG00000166181 E011 409.9014194 0.0008119665 6.328488e-13 1.604326e-11 11 43318640 43318801 162 + 2.508 2.430 -0.260
ENSG00000166181 E012 0.1451727 0.0427568214 1.000000e+00   11 43318802 43318984 183 + 0.056 0.000 -8.002
ENSG00000166181 E013 340.0843567 0.0001762279 1.483787e-11 3.005763e-10 11 43320821 43320914 94 + 2.425 2.367 -0.195
ENSG00000166181 E014 287.0531117 0.0001753084 7.558647e-08 7.857999e-07 11 43321411 43321476 66 + 2.348 2.315 -0.110
ENSG00000166181 E015 282.9820966 0.0002923194 7.858041e-06 5.347278e-05 11 43321985 43322043 59 + 2.337 2.328 -0.033
ENSG00000166181 E016 311.5637090 0.0001470618 2.006244e-10 3.361429e-09 11 43322044 43322136 93 + 2.387 2.332 -0.181
ENSG00000166181 E017 570.8472707 0.0001140388 2.101605e-08 2.440198e-07 11 43323430 43323636 207 + 2.638 2.648 0.031
ENSG00000166181 E018 400.0189625 0.0006932903 1.466693e-05 9.378628e-05 11 43326507 43326611 105 + 2.485 2.489 0.013
ENSG00000166181 E019 417.7530221 0.0001359564 2.764581e-06 2.086073e-05 11 43327789 43327878 90 + 2.503 2.514 0.038
ENSG00000166181 E020 562.1021002 0.0001093658 3.507421e-09 4.699557e-08 11 43328712 43328893 182 + 2.633 2.635 0.008
ENSG00000166181 E021 261.5815834 0.0003947800 1.232655e-06 1.004054e-05 11 43329965 43329985 21 + 2.307 2.279 -0.094
ENSG00000166181 E022 373.1326879 0.0005187298 2.777904e-06 2.095007e-05 11 43329986 43330058 73 + 2.456 2.452 -0.015
ENSG00000166181 E023 12.0186767 0.0014321364 1.368593e-02 3.750555e-02 11 43330233 43330507 275 + 1.037 0.807 -0.870
ENSG00000166181 E024 312.4512052 0.0001738777 2.951243e-03 1.012008e-02 11 43330508 43330564 57 + 2.372 2.412 0.134
ENSG00000166181 E025 194.4464344 0.0002036824 6.237214e-03 1.923556e-02 11 43335278 43335278 1 + 2.169 2.196 0.090
ENSG00000166181 E026 383.7913609 0.0001310283 3.925475e-04 1.746031e-03 11 43335279 43335354 76 + 2.462 2.496 0.116
ENSG00000166181 E027 450.8266480 0.0024801013 5.103459e-02 1.110092e-01 11 43335858 43335994 137 + 2.527 2.581 0.179
ENSG00000166181 E028 21.1360530 0.0008702398 5.736642e-06 4.028280e-05 11 43335995 43336230 236 + 1.107 1.580 1.651
ENSG00000166181 E029 33.6643333 0.0006091807 2.097818e-07 2.003253e-06 11 43339241 43339497 257 + 1.472 1.100 -1.308
ENSG00000166181 E030 6.9557663 0.0078240604 3.398818e-01 4.838085e-01 11 43340224 43340226 3 + 0.803 0.751 -0.206
ENSG00000166181 E031 123.3577582 0.0017341416 1.126816e-03 4.393782e-03 11 43342428 43342432 5 + 1.983 1.946 -0.123
ENSG00000166181 E032 371.5716062 0.0006514564 2.420070e-02 6.022264e-02 11 43342433 43342515 83 + 2.442 2.500 0.194
ENSG00000166181 E033 2598.4598561 0.0093361869 3.474958e-14 1.055847e-12 11 43342516 43344529 2014 + 3.204 3.578 1.244
ENSG00000166181 E034 0.0000000       11 43364830 43364878 49 +