ENSG00000166173

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000299213 ENSG00000166173 HEK293_OSMI2_2hA HEK293_TMG_2hB LARP6 protein_coding protein_coding 45.22597 76.70927 34.74867 5.237787 1.056639 -1.142216 3.480098 5.103478 3.491418 0.7246721 0.1122455 -0.5463654 0.08420833 0.06756667 0.10053333 0.03296667 2.272725e-01 2.50862e-14 FALSE TRUE
ENST00000344870 ENSG00000166173 HEK293_OSMI2_2hA HEK293_TMG_2hB LARP6 protein_coding protein_coding 45.22597 76.70927 34.74867 5.237787 1.056639 -1.142216 36.408959 66.910481 24.007255 4.1300519 1.2547345 -1.4783766 0.77953333 0.87306667 0.68996667 -0.18310000 2.508620e-14 2.50862e-14 FALSE FALSE
ENST00000559316 ENSG00000166173 HEK293_OSMI2_2hA HEK293_TMG_2hB LARP6 protein_coding protein_coding 45.22597 76.70927 34.74867 5.237787 1.056639 -1.142216 1.913150 1.645644 2.619674 0.8230899 0.7051830 0.6674910 0.05271250 0.02036667 0.07516667 0.05480000 4.659423e-01 2.50862e-14   FALSE
MSTRG.11138.2 ENSG00000166173 HEK293_OSMI2_2hA HEK293_TMG_2hB LARP6 protein_coding   45.22597 76.70927 34.74867 5.237787 1.056639 -1.142216 2.734996 2.326151 4.230994 0.5198775 0.9143836 0.8602690 0.06636250 0.02966667 0.12300000 0.09333333 4.032017e-04 2.50862e-14 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000166173 E001 392.061030 0.0106237779 6.541033e-02 1.357290e-01 15 70829130 70832731 3602 - 2.594 2.541 -0.176
ENSG00000166173 E002 110.616593 0.0155975692 3.602296e-02 8.363287e-02 15 70832732 70832881 150 - 2.088 1.977 -0.373
ENSG00000166173 E003 72.029529 0.0032119694 1.074387e-02 3.055414e-02 15 70832882 70832939 58 - 1.899 1.796 -0.346
ENSG00000166173 E004 88.300190 0.0050240964 4.315422e-03 1.402810e-02 15 70832940 70833029 90 - 1.997 1.877 -0.403
ENSG00000166173 E005 91.114383 0.0004207736 8.850678e-08 9.076185e-07 15 70833030 70833116 87 - 2.047 1.870 -0.595
ENSG00000166173 E006 117.070635 0.0015110010 5.507244e-10 8.568748e-09 15 70836295 70836505 211 - 2.168 1.966 -0.678
ENSG00000166173 E007 98.591547 0.0071662570 1.757443e-03 6.463894e-03 15 70851427 70851488 62 - 1.816 2.009 0.649
ENSG00000166173 E008 376.663086 0.0023213911 2.937898e-15 1.046982e-13 15 70851489 70851720 232 - 2.361 2.596 0.785
ENSG00000166173 E009 11.072983 0.0016456832 5.321615e-02 1.148800e-01 15 70851721 70852332 612 - 1.165 0.994 -0.623
ENSG00000166173 E010 4.015972 0.0045297309 8.125210e-01 8.810932e-01 15 70853347 70853525 179 - 0.621 0.675 0.230
ENSG00000166173 E011 403.324774 0.0117091181 5.551777e-02 1.188665e-01 15 70853889 70854171 283 - 2.491 2.596 0.349