ENSG00000166169

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000299206 ENSG00000166169 HEK293_OSMI2_2hA HEK293_TMG_2hB POLL protein_coding protein_coding 33.20294 53.76505 17.00623 2.39365 0.8025856 -1.660025 3.048802 5.980797 1.8257900 0.85903043 0.5004267 -1.706347 0.08782500 0.11033333 0.10603333 -0.00430000 9.467872e-01 1.392092e-26 FALSE  
ENST00000339310 ENSG00000166169 HEK293_OSMI2_2hA HEK293_TMG_2hB POLL protein_coding protein_coding 33.20294 53.76505 17.00623 2.39365 0.8025856 -1.660025 4.114130 7.104017 3.1520058 0.60276666 0.1685933 -1.169824 0.12798333 0.13170000 0.18666667 0.05496667 7.797177e-02 1.392092e-26 FALSE  
ENST00000370162 ENSG00000166169 HEK293_OSMI2_2hA HEK293_TMG_2hB POLL protein_coding protein_coding 33.20294 53.76505 17.00623 2.39365 0.8025856 -1.660025 2.147712 5.331799 0.0000000 0.60845591 0.0000000 -9.061182 0.05030833 0.09856667 0.00000000 -0.09856667 1.392092e-26 1.392092e-26 FALSE  
ENST00000370168 ENSG00000166169 HEK293_OSMI2_2hA HEK293_TMG_2hB POLL protein_coding protein_coding 33.20294 53.76505 17.00623 2.39365 0.8025856 -1.660025 3.326146 3.758851 1.8288813 0.24275593 0.6212071 -1.035296 0.10545000 0.07020000 0.10816667 0.03796667 7.853454e-01 1.392092e-26 FALSE  
ENST00000370169 ENSG00000166169 HEK293_OSMI2_2hA HEK293_TMG_2hB POLL protein_coding protein_coding 33.20294 53.76505 17.00623 2.39365 0.8025856 -1.660025 5.475770 6.759194 2.3896956 0.53586233 0.2017370 -1.496133 0.17484583 0.12563333 0.14086667 0.01523333 7.403964e-01 1.392092e-26 FALSE  
ENST00000463515 ENSG00000166169 HEK293_OSMI2_2hA HEK293_TMG_2hB POLL protein_coding processed_transcript 33.20294 53.76505 17.00623 2.39365 0.8025856 -1.660025 1.965253 2.429393 0.9603048 0.06686631 0.0643260 -1.330012 0.06275417 0.04536667 0.05690000 0.01153333 5.369910e-01 1.392092e-26 FALSE  
MSTRG.4526.2 ENSG00000166169 HEK293_OSMI2_2hA HEK293_TMG_2hB POLL protein_coding   33.20294 53.76505 17.00623 2.39365 0.8025856 -1.660025 3.316641 8.040410 1.0921818 1.50430964 0.3989204 -2.868700 0.08677083 0.15180000 0.06393333 -0.08786667 1.373554e-01 1.392092e-26 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000166169 E001 5.003584 0.0047778636 7.326556e-03 2.206843e-02 10 101578882 101578883 2 - 0.214 0.753 2.876
ENSG00000166169 E002 416.169628 0.0035088108 6.603574e-06 4.574475e-05 10 101578884 101579274 391 - 2.360 2.531 0.570
ENSG00000166169 E003 438.673293 0.0032442751 1.305237e-05 8.437344e-05 10 101579275 101579514 240 - 2.392 2.552 0.533
ENSG00000166169 E004 327.838272 0.0022083588 2.797633e-02 6.796481e-02 10 101579515 101579674 160 - 2.334 2.414 0.269
ENSG00000166169 E005 151.834360 0.0002706822 4.991927e-01 6.355207e-01 10 101579675 101579695 21 - 2.040 2.070 0.103
ENSG00000166169 E006 306.029144 0.0002032621 1.539923e-01 2.671016e-01 10 101579696 101579817 122 - 2.334 2.377 0.143
ENSG00000166169 E007 48.541824 0.0005019240 9.588196e-01 9.781927e-01 10 101579818 101579838 21 - 1.578 1.580 0.007
ENSG00000166169 E008 155.838347 0.0017619801 4.307279e-01 5.733526e-01 10 101580248 101580251 4 - 2.047 2.086 0.129
ENSG00000166169 E009 331.644511 0.0001518042 1.523840e-01 2.649208e-01 10 101580252 101580416 165 - 2.369 2.411 0.138
ENSG00000166169 E010 98.708241 0.0003717388 1.245650e-03 4.795557e-03 10 101580417 101582225 1809 - 1.986 1.856 -0.440
ENSG00000166169 E011 15.188010 0.0123336889 7.188549e-02 1.464779e-01 10 101582621 101582762 142 - 1.243 1.051 -0.687
ENSG00000166169 E012 225.710423 0.0003756271 4.820265e-01 6.201847e-01 10 101582763 101582891 129 - 2.214 2.242 0.093
ENSG00000166169 E013 43.214848 0.0281182296 4.625209e-04 2.016273e-03 10 101582892 101583193 302 - 1.789 1.444 -1.175
ENSG00000166169 E014 141.685646 0.0002466657 7.912918e-02 1.581207e-01 10 101583508 101583601 94 - 1.972 2.046 0.248
ENSG00000166169 E015 125.093287 0.0003085525 1.080593e-01 2.026560e-01 10 101583602 101583681 80 - 1.919 1.991 0.243
ENSG00000166169 E016 78.144391 0.0070163343 9.402350e-01 9.664635e-01 10 101584602 101584610 9 - 1.783 1.786 0.011
ENSG00000166169 E017 148.955342 0.0002982391 5.870605e-01 7.104465e-01 10 101584611 101584686 76 - 2.069 2.055 -0.048
ENSG00000166169 E018 109.412740 0.0033952606 7.049315e-01 8.033733e-01 10 101584687 101584720 34 - 1.932 1.920 -0.040
ENSG00000166169 E019 129.579356 0.0068226119 3.015768e-01 4.434055e-01 10 101584721 101584793 73 - 2.037 1.988 -0.167
ENSG00000166169 E020 125.448535 0.0003064443 9.275042e-02 1.794234e-01 10 101584794 101584877 84 - 2.030 1.970 -0.201
ENSG00000166169 E021 103.087626 0.0003035751 1.923483e-01 3.167109e-01 10 101584878 101584919 42 - 1.938 1.888 -0.169
ENSG00000166169 E022 60.726159 0.0004326698 4.215039e-01 5.646489e-01 10 101585316 101585323 8 - 1.626 1.679 0.178
ENSG00000166169 E023 132.812842 0.0040448052 2.378831e-01 3.716772e-01 10 101585324 101585478 155 - 1.954 2.020 0.221
ENSG00000166169 E024 216.728901 0.0022978200 2.847959e-01 4.250601e-01 10 101585862 101586156 295 - 2.177 2.226 0.164
ENSG00000166169 E025 10.343614 0.0216285543 8.784223e-01 9.259187e-01 10 101587122 101587200 79 - 0.936 0.966 0.114
ENSG00000166169 E026 178.600824 0.0008688059 2.212786e-02 5.593986e-02 10 101587246 101587291 46 - 2.193 2.120 -0.243
ENSG00000166169 E027 196.822799 0.0047790276 2.003374e-03 7.236649e-03 10 101587292 101587382 91 - 2.279 2.152 -0.424
ENSG00000166169 E028 116.327984 0.0009078296 4.920969e-05 2.777402e-04 10 101587383 101587403 21 - 2.074 1.916 -0.529
ENSG00000166169 E029 83.458340 0.0047689480 2.596144e-03 9.054504e-03 10 101587404 101587406 3 - 1.935 1.775 -0.538
ENSG00000166169 E030 157.225819 0.0005264779 5.019737e-11 9.328762e-10 10 101587407 101587821 415 - 2.246 2.033 -0.714
ENSG00000166169 E031 75.160172 0.0048205363 3.216180e-01 4.648770e-01 10 101587822 101587884 63 - 1.801 1.751 -0.169
ENSG00000166169 E032 167.427634 0.0051257562 1.021055e-02 2.928493e-02 10 101587885 101588203 319 - 2.195 2.085 -0.367
ENSG00000166169 E033 21.336501 0.0008830233 1.016196e-01 1.929590e-01 10 101588204 101588270 67 - 1.342 1.205 -0.481