ENSG00000166167

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000370183 ENSG00000166167 HEK293_OSMI2_2hA HEK293_TMG_2hB BTRC protein_coding protein_coding 13.44143 9.667004 15.84356 1.161079 0.4474997 0.7121745 1.65021706 0.0000000 2.8398454 0.00000000 0.2889177 8.1547398 0.10040417 0.00000000 0.1795333 0.17953333 4.498015e-21 4.498015e-21 FALSE FALSE
ENST00000370187 ENSG00000166167 HEK293_OSMI2_2hA HEK293_TMG_2hB BTRC protein_coding protein_coding 13.44143 9.667004 15.84356 1.161079 0.4474997 0.7121745 2.58928630 2.8595940 3.2467190 1.13976248 0.4566101 0.1825726 0.20755833 0.27840000 0.2052333 -0.07316667 7.368314e-01 4.498015e-21 FALSE TRUE
ENST00000393441 ENSG00000166167 HEK293_OSMI2_2hA HEK293_TMG_2hB BTRC protein_coding protein_coding 13.44143 9.667004 15.84356 1.161079 0.4474997 0.7121745 0.87729312 0.6373691 0.9390138 0.08452569 0.2380792 0.5518407 0.06712917 0.07026667 0.0602000 -0.01006667 9.015221e-01 4.498015e-21 FALSE TRUE
ENST00000408038 ENSG00000166167 HEK293_OSMI2_2hA HEK293_TMG_2hB BTRC protein_coding protein_coding 13.44143 9.667004 15.84356 1.161079 0.4474997 0.7121745 6.33757791 4.6960386 7.2125955 0.91630424 0.5930429 0.6180042 0.48108333 0.48076667 0.4539000 -0.02686667 9.150099e-01 4.498015e-21 FALSE TRUE
MSTRG.4523.9 ENSG00000166167 HEK293_OSMI2_2hA HEK293_TMG_2hB BTRC protein_coding   13.44143 9.667004 15.84356 1.161079 0.4474997 0.7121745 0.08451626 0.4645118 0.0000000 0.33968118 0.0000000 -5.5683722 0.00892500 0.05893333 0.0000000 -0.05893333 2.002877e-01 4.498015e-21 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000166167 E001 0.1515154 0.0439691289 6.183298e-01   10 101354033 101354068 36 + 0.103 0.000 -9.970
ENSG00000166167 E002 5.0700116 0.0046618681 6.521335e-01 0.7628667168 10 101354069 101354106 38 + 0.721 0.843 0.485
ENSG00000166167 E003 19.8178342 0.0351538436 3.757854e-01 0.5201996861 10 101354107 101354164 58 + 1.333 1.282 -0.180
ENSG00000166167 E004 26.7105625 0.0356169778 9.953823e-02 0.1897753596 10 101354165 101354181 17 + 1.490 1.359 -0.451
ENSG00000166167 E005 38.7307774 0.0156758519 2.785994e-02 0.0677394101 10 101354182 101354228 47 + 1.646 1.523 -0.418
ENSG00000166167 E006 1.5373489 0.1386861226 2.046539e-01 0.3319667779 10 101354534 101354609 76 + 0.495 0.254 -1.414
ENSG00000166167 E007 0.1515154 0.0439691289 6.183298e-01   10 101407440 101407440 1 + 0.103 0.000 -9.970
ENSG00000166167 E008 3.2336118 0.0587891777 2.862950e-01 0.4266990930 10 101407441 101407533 93 + 0.675 0.533 -0.628
ENSG00000166167 E009 1.1072260 1.3961488552 3.655550e-01 0.5098602624 10 101407779 101407865 87 + 0.000 0.522 13.398
ENSG00000166167 E010 27.2507646 0.0007359752 5.236369e-02 0.1133704775 10 101430345 101430452 108 + 1.474 1.416 -0.200
ENSG00000166167 E011 0.1451727 0.0440199487 6.186587e-01   10 101453501 101453556 56 + 0.103 0.000 -9.969
ENSG00000166167 E012 0.0000000       10 101461964 101461980 17 +      
ENSG00000166167 E013 66.3157419 0.0012160706 1.643520e-03 0.0060999534 10 101461981 101462058 78 + 1.858 1.785 -0.245
ENSG00000166167 E014 87.1852530 0.0005589969 2.951313e-05 0.0001759393 10 101479368 101479457 90 + 1.984 1.895 -0.299
ENSG00000166167 E015 150.3645344 0.0022504040 4.152993e-04 0.0018329420 10 101521639 101521870 232 + 2.204 2.148 -0.189
ENSG00000166167 E016 130.4623637 0.0037533801 4.395023e-03 0.0142501826 10 101526013 101526199 187 + 2.140 2.090 -0.170
ENSG00000166167 E017 90.6504983 0.0023572435 3.155734e-04 0.0014430923 10 101531237 101531333 97 + 1.997 1.910 -0.293
ENSG00000166167 E018 112.3039810 0.0008520613 2.673761e-03 0.0092942374 10 101532295 101532432 138 + 2.069 2.035 -0.114
ENSG00000166167 E019 108.7629537 0.0007060838 2.985602e-02 0.0716809993 10 101532952 101533070 119 + 2.042 2.038 -0.015
ENSG00000166167 E020 150.4425816 0.0007313581 9.830455e-02 0.1879385229 10 101534661 101534910 250 + 2.171 2.193 0.072
ENSG00000166167 E021 70.3053164 0.0030836273 1.247684e-01 0.2268013313 10 101535354 101535383 30 + 1.855 1.850 -0.016
ENSG00000166167 E022 99.8044983 0.0003112740 2.062039e-02 0.0527880007 10 101535384 101535472 89 + 2.010 2.001 -0.027
ENSG00000166167 E023 110.8363477 0.0003363248 4.620655e-01 0.6019634944 10 101536543 101536653 111 + 2.028 2.077 0.163
ENSG00000166167 E024 74.7936390 0.0024640619 3.586569e-01 0.5030425886 10 101538293 101538371 79 + 1.826 1.938 0.376
ENSG00000166167 E025 122.8404533 0.0018434934 6.728517e-01 0.7787121961 10 101550699 101550891 193 + 2.052 2.138 0.287
ENSG00000166167 E026 2.5872565 0.0059391498 9.674648e-01 0.9836542085 10 101550892 101551191 300 + 0.531 0.578 0.215
ENSG00000166167 E027 1119.1298925 0.0094695358 2.509669e-04 0.0011793650 10 101553155 101557321 4167 + 2.960 3.136 0.588