ENSG00000166164

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000394689 ENSG00000166164 HEK293_OSMI2_2hA HEK293_TMG_2hB BRD7 protein_coding protein_coding 65.99577 59.47219 75.3436 2.590275 0.9394614 0.3412187 33.120085 26.680345 38.488640 1.285255 1.276391 0.5284895 0.50260833 0.4514000 0.51063333 0.05923333 5.318773e-01 3.913277e-34 FALSE TRUE
ENST00000475877 ENSG00000166164 HEK293_OSMI2_2hA HEK293_TMG_2hB BRD7 protein_coding processed_transcript 65.99577 59.47219 75.3436 2.590275 0.9394614 0.3412187 2.522621 0.000000 4.493370 0.000000 1.192875 8.8148613 0.03352917 0.0000000 0.05946667 0.05946667 4.395893e-16 3.913277e-34 FALSE FALSE
ENST00000569774 ENSG00000166164 HEK293_OSMI2_2hA HEK293_TMG_2hB BRD7 protein_coding protein_coding 65.99577 59.47219 75.3436 2.590275 0.9394614 0.3412187 5.592967 11.790432 1.118733 3.282402 1.118733 -3.3860630 0.08974167 0.1944000 0.01523333 -0.17916667 3.834549e-02 3.913277e-34 FALSE FALSE
MSTRG.12624.13 ENSG00000166164 HEK293_OSMI2_2hA HEK293_TMG_2hB BRD7 protein_coding   65.99577 59.47219 75.3436 2.590275 0.9394614 0.3412187 5.714173 9.725945 4.491194 1.264620 2.326379 -1.1130134 0.09016250 0.1628667 0.06020000 -0.10266667 5.931285e-01 3.913277e-34 FALSE TRUE
MSTRG.12624.9 ENSG00000166164 HEK293_OSMI2_2hA HEK293_TMG_2hB BRD7 protein_coding   65.99577 59.47219 75.3436 2.590275 0.9394614 0.3412187 6.276295 0.000000 11.226162 0.000000 1.716793 10.1339337 0.08805417 0.0000000 0.14866667 0.14866667 3.913277e-34 3.913277e-34 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000166164 E001 19.9994918 0.0369293754 4.096299e-04 1.811214e-03 16 50313487 50313656 170 - 1.045 1.494 1.584
ENSG00000166164 E002 100.6830472 0.0007960001 1.686261e-16 7.056705e-15 16 50313657 50314412 756 - 1.826 2.136 1.042
ENSG00000166164 E003 17.0862637 0.0015233255 3.772055e-01 5.215520e-01 16 50314413 50314435 23 - 1.219 1.288 0.241
ENSG00000166164 E004 24.3408427 0.0007708326 1.021950e-01 1.938591e-01 16 50314436 50314492 57 - 1.344 1.454 0.381
ENSG00000166164 E005 63.2649309 0.0124994829 2.301229e-02 5.777455e-02 16 50314493 50315385 893 - 1.721 1.872 0.513
ENSG00000166164 E006 13.5377257 0.0194065139 8.551140e-02 1.682300e-01 16 50315386 50315457 72 - 1.056 1.240 0.658
ENSG00000166164 E007 23.4091910 0.0008253749 1.944920e-01 3.193883e-01 16 50315458 50315714 257 - 1.344 1.432 0.305
ENSG00000166164 E008 13.6051468 0.0012659075 5.363309e-01 6.680843e-01 16 50315715 50315770 56 - 1.140 1.192 0.185
ENSG00000166164 E009 22.4351322 0.0008251456 5.322620e-01 6.646285e-01 16 50315771 50315946 176 - 1.350 1.391 0.143
ENSG00000166164 E010 9.6310918 0.0018144354 4.530460e-01 5.938271e-01 16 50315947 50315956 10 - 1.067 0.986 -0.300
ENSG00000166164 E011 9.9298562 0.0017073047 3.301584e-01 4.737479e-01 16 50315957 50315958 2 - 1.090 0.986 -0.380
ENSG00000166164 E012 14.9840725 0.0011862710 8.641426e-01 9.163941e-01 16 50315959 50316023 65 - 1.211 1.192 -0.066
ENSG00000166164 E013 42.8958541 0.0006287068 2.799213e-02 6.799623e-02 16 50316024 50317522 1499 - 1.700 1.577 -0.417
ENSG00000166164 E014 7.5654183 0.0048198891 2.743064e-01 4.134415e-01 16 50317523 50317653 131 - 0.993 0.860 -0.502
ENSG00000166164 E015 28.2923920 0.0007600811 6.530030e-02 1.355393e-01 16 50317654 50317892 239 - 1.527 1.403 -0.427
ENSG00000166164 E016 220.7342258 0.0002660321 2.768878e-05 1.660197e-04 16 50317893 50319029 1137 - 2.399 2.291 -0.357
ENSG00000166164 E017 103.9939894 0.0008280647 1.233421e-01 2.247282e-01 16 50319030 50319182 153 - 1.995 2.048 0.175
ENSG00000166164 E018 118.9338979 0.0006708279 1.037278e-07 1.050459e-06 16 50319183 50319201 19 - 1.982 2.161 0.600
ENSG00000166164 E019 328.8527000 0.0001862594 5.062195e-06 3.598161e-05 16 50319202 50319266 65 - 2.474 2.561 0.292
ENSG00000166164 E020 589.5659623 0.0001621215 1.550562e-12 3.680608e-11 16 50319887 50320030 144 - 2.717 2.820 0.344
ENSG00000166164 E021 680.8320382 0.0003626142 1.997812e-07 1.914026e-06 16 50320248 50320391 144 - 2.794 2.870 0.256
ENSG00000166164 E022 595.6020927 0.0002035016 8.918882e-06 5.999345e-05 16 50320663 50320774 112 - 2.743 2.807 0.213
ENSG00000166164 E023 114.8041264 0.0003234237 9.115624e-02 1.769411e-01 16 50320775 50320777 3 - 2.040 2.093 0.176
ENSG00000166164 E024 490.2887639 0.0008779510 9.320883e-04 3.726524e-03 16 50321982 50322038 57 - 2.658 2.724 0.218
ENSG00000166164 E025 615.4439905 0.0015451976 9.187054e-04 3.680008e-03 16 50323587 50323698 112 - 2.753 2.825 0.240
ENSG00000166164 E026 626.2195131 0.0003950203 4.296299e-05 2.458679e-04 16 50325748 50325883 136 - 2.765 2.829 0.210
ENSG00000166164 E027 467.6392871 0.0001433862 4.105770e-02 9.298909e-02 16 50326284 50326391 108 - 2.657 2.687 0.101
ENSG00000166164 E028 355.4244890 0.0001352098 1.660241e-03 6.154419e-03 16 50328669 50328744 76 - 2.584 2.520 -0.213
ENSG00000166164 E029 424.1304215 0.0002425568 3.186872e-03 1.081706e-02 16 50333574 50333697 124 - 2.657 2.599 -0.194
ENSG00000166164 E030 479.8390477 0.0002821470 1.102641e-03 4.311943e-03 16 50334711 50334895 185 - 2.712 2.650 -0.206
ENSG00000166164 E031 307.4915552 0.0001796645 9.208526e-04 3.687985e-03 16 50339976 50340086 111 - 2.525 2.452 -0.243
ENSG00000166164 E032 6.1351440 0.0946297640 1.752625e-01 2.950195e-01 16 50349023 50349623 601 - 0.723 0.951 0.887
ENSG00000166164 E033 0.2214452 0.0395419280 4.248947e-01   16 50350017 50350022 6 - 0.000 0.130 9.425
ENSG00000166164 E034 363.5891755 0.0009341553 7.263856e-05 3.928392e-04 16 50350023 50350167 145 - 2.610 2.512 -0.327
ENSG00000166164 E035 355.4651889 0.0019916261 1.854216e-03 6.770928e-03 16 50354425 50354479 55 - 2.598 2.503 -0.314
ENSG00000166164 E036 217.4985213 0.0018990381 1.816475e-05 1.137869e-04 16 50354480 50354482 3 - 2.407 2.265 -0.473
ENSG00000166164 E037 422.6083082 0.0001457720 1.551370e-11 3.130617e-10 16 50354793 50354922 130 - 2.687 2.564 -0.410
ENSG00000166164 E038 0.3729606 0.0261412468 9.180663e-01 9.522253e-01 16 50361792 50361833 42 - 0.116 0.130 0.188
ENSG00000166164 E039 5.0618132 0.0031301815 2.852244e-03 9.829890e-03 16 50368039 50368089 51 - 0.951 0.535 -1.708
ENSG00000166164 E040 393.7529027 0.0011380579 5.111636e-20 3.253979e-18 16 50368090 50368298 209 - 2.697 2.472 -0.751
ENSG00000166164 E041 150.5994237 0.0135851752 2.247554e-12 5.208469e-11 16 50368726 50368988 263 - 2.360 1.892 -1.569