ENSG00000166147

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000316623 ENSG00000166147 HEK293_OSMI2_2hA HEK293_TMG_2hB FBN1 protein_coding protein_coding 3.621215 3.173942 4.129878 0.0963576 0.3555554 0.378774 1.0812473 0.6441981 1.421310 0.1477356 0.16862228 1.1295369 0.2942458 0.2042667 0.35240000 0.14813333 2.782964e-01 7.337278e-06 FALSE TRUE
ENST00000559133 ENSG00000166147 HEK293_OSMI2_2hA HEK293_TMG_2hB FBN1 protein_coding nonsense_mediated_decay 3.621215 3.173942 4.129878 0.0963576 0.3555554 0.378774 1.7890168 2.0875393 1.601949 0.2824328 0.17149140 -0.3798914 0.5041250 0.6544667 0.38660000 -0.26786667 2.448379e-02 7.337278e-06 TRUE TRUE
ENST00000682158 ENSG00000166147 HEK293_OSMI2_2hA HEK293_TMG_2hB FBN1 protein_coding retained_intron 3.621215 3.173942 4.129878 0.0963576 0.3555554 0.378774 0.2022314 0.3963666 0.134694 0.3004906 0.08599171 -1.4897765 0.0613000 0.1265667 0.02953333 -0.09703333 7.788298e-01 7.337278e-06 FALSE TRUE
ENST00000684448 ENSG00000166147 HEK293_OSMI2_2hA HEK293_TMG_2hB FBN1 protein_coding retained_intron 3.621215 3.173942 4.129878 0.0963576 0.3555554 0.378774 0.3738190 0.0000000 0.744464 0.0000000 0.28682207 6.2373801 0.0908500 0.0000000 0.17406667 0.17406667 7.337278e-06 7.337278e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000166147 E001 1.5811763 0.0091918101 9.625072e-05 5.044795e-04 15 48408313 48408503 191 - 0.000 0.680 16.829
ENSG00000166147 E002 12.1218013 0.0014782467 8.182505e-06 5.544967e-05 15 48408504 48410073 1570 - 0.847 1.318 1.716
ENSG00000166147 E003 4.6433850 0.0131258826 3.224091e-06 2.395835e-05 15 48410074 48410101 28 - 0.302 1.028 3.267
ENSG00000166147 E004 138.1909943 0.0303877973 2.384700e-09 3.298345e-08 15 48410102 48411093 992 - 1.824 2.372 1.836
ENSG00000166147 E005 31.4681777 0.0008397760 6.697181e-06 4.633051e-05 15 48411094 48411200 107 - 1.340 1.660 1.100
ENSG00000166147 E006 48.1705671 0.0005403565 1.018565e-06 8.433379e-06 15 48411201 48411379 179 - 1.534 1.822 0.979
ENSG00000166147 E007 41.7417043 0.0005722101 8.411489e-07 7.100982e-06 15 48412569 48412743 175 - 1.461 1.769 1.051
ENSG00000166147 E008 37.4610921 0.0005976405 1.114250e-03 4.351590e-03 15 48415536 48415767 232 - 1.465 1.691 0.772
ENSG00000166147 E009 2.1686798 0.3319367540 6.816696e-01 7.853097e-01 15 48415768 48416642 875 - 0.548 0.423 -0.621
ENSG00000166147 E010 1.2596890 0.0101107020 3.894464e-01 5.335292e-01 15 48416643 48416967 325 - 0.399 0.266 -0.839
ENSG00000166147 E011 28.1149985 0.0007591580 5.515843e-03 1.732792e-02 15 48420687 48420806 120 - 1.345 1.566 0.764
ENSG00000166147 E012 29.9827685 0.0007136087 1.012899e-01 1.924353e-01 15 48421558 48421686 129 - 1.417 1.561 0.495
ENSG00000166147 E013 26.7740881 0.0007418442 3.790172e-01 5.233161e-01 15 48421952 48422068 117 - 1.391 1.490 0.342
ENSG00000166147 E014 22.1843204 0.0009080474 9.043180e-01 9.430823e-01 15 48425369 48425491 123 - 1.345 1.376 0.109
ENSG00000166147 E015 21.6330852 0.0008778997 4.708799e-02 1.039803e-01 15 48425739 48425864 126 - 1.391 1.282 -0.382
ENSG00000166147 E016 29.1258980 0.0063909075 5.830005e-01 7.072047e-01 15 48427567 48427773 207 - 1.472 1.473 0.004
ENSG00000166147 E017 0.0000000       15 48427774 48427881 108 -      
ENSG00000166147 E018 0.0000000       15 48427882 48427943 62 -      
ENSG00000166147 E019 0.1451727 0.0443926968 7.121193e-01   15 48427944 48428345 402 - 0.097 0.000 -12.476
ENSG00000166147 E020 23.7149566 0.0094264142 5.081263e-01 6.435768e-01 15 48428346 48428471 126 - 1.339 1.435 0.332
ENSG00000166147 E021 0.1515154 0.0430427297 7.123712e-01   15 48428472 48428577 106 - 0.097 0.000 -12.477
ENSG00000166147 E022 20.7905305 0.0073783503 3.165693e-01 4.593531e-01 15 48430671 48430763 93 - 1.275 1.399 0.430
ENSG00000166147 E023 14.5797533 0.0028760579 6.869951e-01 7.894095e-01 15 48430764 48430802 39 - 1.156 1.231 0.266
ENSG00000166147 E024 19.7556489 0.0027320777 2.132199e-01 3.423354e-01 15 48432866 48432988 123 - 1.245 1.384 0.484
ENSG00000166147 E025 0.0000000       15 48434108 48434212 105 -      
ENSG00000166147 E026 20.4277374 0.0009244318 1.810095e-01 3.024761e-01 15 48434594 48434713 120 - 1.257 1.398 0.492
ENSG00000166147 E027 20.8794899 0.0058117822 6.424205e-01 7.552071e-01 15 48436961 48437077 117 - 1.298 1.377 0.275
ENSG00000166147 E028 13.4376688 0.0347508392 3.061844e-01 4.483545e-01 15 48437322 48437387 66 - 1.192 1.094 -0.351
ENSG00000166147 E029 0.0000000       15 48437622 48437767 146 -      
ENSG00000166147 E030 22.1809579 0.0135231406 9.818728e-01 9.926728e-01 15 48437768 48437917 150 - 1.339 1.378 0.134
ENSG00000166147 E031 20.4600281 0.0015202714 6.566294e-01 7.661438e-01 15 48441721 48441846 126 - 1.287 1.361 0.258
ENSG00000166147 E032 0.0000000       15 48444102 48444540 439 -      
ENSG00000166147 E033 21.5640647 0.0009784277 7.650412e-01 8.479105e-01 15 48444541 48444660 120 - 1.335 1.352 0.062
ENSG00000166147 E034 20.5909021 0.0014207524 2.218522e-02 5.605766e-02 15 48445376 48445504 129 - 1.220 1.434 0.747
ENSG00000166147 E035 19.8622409 0.0027695629 5.241856e-01 6.578084e-01 15 48446706 48446822 117 - 1.269 1.361 0.318
ENSG00000166147 E036 21.2649416 0.0041933292 8.935745e-01 9.359382e-01 15 48448768 48448893 126 - 1.330 1.360 0.106
ENSG00000166147 E037 17.5103311 0.0011668284 6.019742e-02 1.269427e-01 15 48452562 48452684 123 - 1.303 1.186 -0.414
ENSG00000166147 E038 16.7486477 0.0062055530 2.039734e-01 3.311466e-01 15 48456637 48456762 126 - 1.263 1.187 -0.268
ENSG00000166147 E039 16.9930099 0.0376228547 2.363448e-01 3.699327e-01 15 48460246 48460317 72 - 1.275 1.185 -0.316
ENSG00000166147 E040 23.5949880 0.0144039476 1.038653e-01 1.963947e-01 15 48463082 48463240 159 - 1.417 1.315 -0.355
ENSG00000166147 E041 17.7860896 0.0108279438 2.414997e-01 3.759451e-01 15 48463899 48464021 123 - 1.293 1.221 -0.250
ENSG00000166147 E042 14.7083613 0.0339336150 2.764724e-01 4.159400e-01 15 48465568 48465693 126 - 1.227 1.124 -0.367
ENSG00000166147 E043 11.5160887 0.0114396748 1.313223e-01 2.359907e-01 15 48465790 48465858 69 - 1.141 1.012 -0.468
ENSG00000166147 E044 17.8964401 0.0010793592 2.166363e-01 3.463422e-01 15 48467938 48468102 165 - 1.292 1.231 -0.215
ENSG00000166147 E045 16.0883031 0.0011614388 1.010191e-01 1.920139e-01 15 48468412 48468534 123 - 1.263 1.161 -0.362
ENSG00000166147 E046 0.0000000       15 48470093 48470633 541 -      
ENSG00000166147 E047 14.5236723 0.0018791050 9.155932e-03 2.667206e-02 15 48470634 48470756 123 - 1.251 1.046 -0.733
ENSG00000166147 E048 14.9836523 0.0111452715 1.962119e-01 3.214911e-01 15 48472551 48472676 126 - 1.226 1.137 -0.317
ENSG00000166147 E049 0.0000000       15 48472677 48472853 177 -      
ENSG00000166147 E050 14.0415811 0.0286148795 3.097189e-01 4.520614e-01 15 48474255 48474377 123 - 1.200 1.123 -0.274
ENSG00000166147 E051 19.4037386 0.0147080340 2.050354e-01 3.324489e-01 15 48474528 48474650 123 - 1.330 1.255 -0.263
ENSG00000166147 E052 17.2289455 0.0056872260 2.779545e-02 6.761034e-02 15 48481655 48481780 126 - 1.309 1.149 -0.562
ENSG00000166147 E053 14.6424115 0.0606175990 2.127287e-02 5.416047e-02 15 48483818 48483943 126 - 1.282 1.000 -1.010
ENSG00000166147 E054 15.6796882 0.0012750602 2.863072e-06 2.152041e-05 15 48485374 48485496 123 - 1.340 0.934 -1.458
ENSG00000166147 E055 15.5227499 0.0011042352 2.468014e-07 2.323846e-06 15 48487075 48487200 126 - 1.349 0.889 -1.663
ENSG00000166147 E056 14.9503633 0.0012093240 9.813776e-06 6.537468e-05 15 48487312 48487437 126 - 1.319 0.934 -1.388
ENSG00000166147 E057 15.0886477 0.0011815101 4.479879e-03 1.448491e-02 15 48488113 48488241 129 - 1.281 1.062 -0.780
ENSG00000166147 E058 12.4796318 0.0014010789 6.359974e-03 1.955685e-02 15 48488368 48488493 126 - 1.206 0.975 -0.839
ENSG00000166147 E059 14.2739742 0.0041386254 2.333678e-01 3.664052e-01 15 48489851 48490078 228 - 1.206 1.135 -0.253
ENSG00000166147 E060 8.1221371 0.0020812532 1.328268e-01 2.380430e-01 15 48492461 48492586 126 - 1.002 0.865 -0.516
ENSG00000166147 E061 6.0152622 0.0028115450 6.921107e-02 1.420643e-01 15 48494204 48494254 51 - 0.918 0.717 -0.790
ENSG00000166147 E062 11.1600399 0.0028683490 6.997867e-02 1.433386e-01 15 48495123 48495260 138 - 1.140 0.993 -0.535
ENSG00000166147 E063 10.7173504 0.0055799565 2.349964e-02 5.877377e-02 15 48495469 48495588 120 - 1.140 0.934 -0.756
ENSG00000166147 E064 10.9827883 0.0015574973 6.791776e-02 1.399123e-01 15 48496100 48496225 126 - 1.124 0.975 -0.546
ENSG00000166147 E065 9.5885357 0.0019969652 1.249390e-01 2.270371e-01 15 48497266 48497391 126 - 1.063 0.934 -0.475
ENSG00000166147 E066 9.8580522 0.0023390430 4.089162e-01 5.525255e-01 15 48498985 48499038 54 - 1.043 0.994 -0.182
ENSG00000166147 E067 14.1468386 0.0012734090 2.620083e-03 9.127411e-03 15 48503787 48503939 153 - 1.257 1.012 -0.881
ENSG00000166147 E068 13.6287939 0.0013321238 4.775030e-04 2.073854e-03 15 48505025 48505147 123 - 1.257 0.955 -1.093
ENSG00000166147 E069 11.2811930 0.0021712622 3.017997e-04 1.386835e-03 15 48508582 48508704 123 - 1.192 0.839 -1.304
ENSG00000166147 E070 12.1531345 0.0015154461 1.359520e-05 8.755380e-05 15 48510044 48510169 126 - 1.239 0.812 -1.575
ENSG00000166147 E071 9.7501572 0.0131094094 1.963435e-02 5.070431e-02 15 48513549 48513668 120 - 1.107 0.866 -0.896
ENSG00000166147 E072 7.8416954 0.0054306653 9.733249e-02 1.864086e-01 15 48515387 48515527 141 - 1.002 0.839 -0.616
ENSG00000166147 E073 0.0000000       15 48515528 48515528 1 -      
ENSG00000166147 E074 9.1972528 0.0329378606 9.442157e-02 1.820107e-01 15 48516183 48516362 180 - 1.081 0.886 -0.721
ENSG00000166147 E075 9.4261971 0.0018798253 2.060302e-01 3.337193e-01 15 48520659 48520817 159 - 1.053 0.955 -0.363
ENSG00000166147 E076 8.8779661 0.0022734368 2.380437e-03 8.399387e-03 15 48526130 48526255 126 - 1.099 0.782 -1.193
ENSG00000166147 E077 8.1320554 0.0080656114 2.758725e-02 6.718754e-02 15 48534080 48534205 126 - 1.043 0.811 -0.876
ENSG00000166147 E078 8.0598192 0.0302921415 1.878901e-01 3.110844e-01 15 48537611 48537710 100 - 1.012 0.863 -0.560
ENSG00000166147 E079 9.3123619 0.0032168271 3.918442e-02 8.952341e-02 15 48537711 48537808 98 - 1.081 0.889 -0.713
ENSG00000166147 E080 7.1377051 0.0052048077 6.118518e-02 1.286213e-01 15 48596283 48596378 96 - 0.980 0.782 -0.756
ENSG00000166147 E081 7.3633055 0.0286228994 1.864627e-02 4.855708e-02 15 48600139 48600234 96 - 1.023 0.717 -1.180
ENSG00000166147 E082 10.1785575 0.0017033081 1.214176e-05 7.910787e-05 15 48610728 48610826 99 - 1.185 0.717 -1.765
ENSG00000166147 E083 9.0194692 0.0018616876 1.873437e-06 1.466660e-05 15 48613010 48613092 83 - 1.156 0.597 -2.175
ENSG00000166147 E084 2.1358308 0.0067205469 1.164287e-01 2.148618e-01 15 48640989 48642846 1858 - 0.353 0.641 1.424
ENSG00000166147 E085 0.4417591 0.2402683180 4.245335e-01 5.674914e-01 15 48642847 48643101 255 - 0.097 0.261 1.713
ENSG00000166147 E086 3.9803908 0.0048069986 6.012119e-01 7.223488e-01 15 48643102 48644605 1504 - 0.722 0.680 -0.173
ENSG00000166147 E087 11.5909184 0.0015103684 1.102232e-04 5.689614e-04 15 48644606 48644950 345 - 1.213 0.839 -1.377
ENSG00000166147 E088 2.4723495 0.0076519581 3.012102e-01 4.429973e-01 15 48645575 48645721 147 - 0.576 0.430 -0.711