ENSG00000166140

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355341 ENSG00000166140 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFYVE19 protein_coding protein_coding 19.54143 28.14865 12.27909 1.483764 0.4868728 -1.1962 4.238025 6.0429739 2.6500361 0.4773279 0.04801695 -1.18619833 0.21344583 0.21450000 0.21630000 0.001800000 0.9980422889 0.0002957762 FALSE TRUE
ENST00000560078 ENSG00000166140 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFYVE19 protein_coding retained_intron 19.54143 28.14865 12.27909 1.483764 0.4868728 -1.1962 2.275672 2.4863383 1.5414902 0.1885506 0.04217686 -0.68615893 0.12290417 0.08820000 0.12583333 0.037633333 0.0774603406 0.0002957762 FALSE TRUE
ENST00000566407 ENSG00000166140 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFYVE19 protein_coding protein_coding 19.54143 28.14865 12.27909 1.483764 0.4868728 -1.1962 1.415494 1.8057811 1.8755399 0.6511039 0.39293356 0.05438739 0.07751667 0.06620000 0.15456667 0.088366667 0.2174226457 0.0002957762 FALSE FALSE
ENST00000566767 ENSG00000166140 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFYVE19 protein_coding protein_coding 19.54143 28.14865 12.27909 1.483764 0.4868728 -1.1962 2.139689 3.1195135 1.6893039 0.5889998 0.25159354 -0.88099450 0.11104583 0.10953333 0.13680000 0.027266667 0.6382095398 0.0002957762   FALSE
ENST00000567756 ENSG00000166140 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFYVE19 protein_coding nonsense_mediated_decay 19.54143 28.14865 12.27909 1.483764 0.4868728 -1.1962 1.164910 1.2871063 0.5070102 0.9573308 0.50701024 -1.32703193 0.05514583 0.04260000 0.04093333 -0.001666667 0.7057387967 0.0002957762 FALSE FALSE
ENST00000569057 ENSG00000166140 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFYVE19 protein_coding nonsense_mediated_decay 19.54143 28.14865 12.27909 1.483764 0.4868728 -1.1962 2.368824 4.1609037 1.0321076 0.7745750 0.53024462 -2.00085569 0.12369167 0.15050000 0.08086667 -0.069633333 0.6738938137 0.0002957762 FALSE TRUE
ENST00000570162 ENSG00000166140 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFYVE19 protein_coding retained_intron 19.54143 28.14865 12.27909 1.483764 0.4868728 -1.1962 1.303920 0.6741011 1.0867668 0.1374233 0.09059445 0.68097525 0.07714167 0.02453333 0.08936667 0.064833333 0.0007359136 0.0002957762 FALSE FALSE
MSTRG.10580.12 ENSG00000166140 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFYVE19 protein_coding   19.54143 28.14865 12.27909 1.483764 0.4868728 -1.1962 3.247766 5.6722837 1.4603593 0.5801039 0.12772512 -1.95030211 0.15713750 0.20080000 0.11883333 -0.081966667 0.0060010243 0.0002957762 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000166140 E001 4.743898 0.0115310142 2.251970e-01 3.566564e-01 15 40807086 40807088 3 + 0.813 0.632 -0.741
ENSG00000166140 E002 35.301185 0.0006324890 3.518530e-02 8.199560e-02 15 40807089 40807233 145 + 1.578 1.444 -0.459
ENSG00000166140 E003 59.684699 0.0042879187 6.263894e-03 1.930465e-02 15 40807234 40807413 180 + 1.815 1.659 -0.527
ENSG00000166140 E004 25.729116 0.0007947127 2.105175e-02 5.370265e-02 15 40807414 40807421 8 + 1.471 1.303 -0.584
ENSG00000166140 E005 63.572641 0.0011411158 2.264284e-03 8.043846e-03 15 40807422 40807589 168 + 1.840 1.689 -0.511
ENSG00000166140 E006 39.019431 0.0082163511 5.160078e-01 6.506102e-01 15 40807590 40807641 52 + 1.558 1.509 -0.169
ENSG00000166140 E007 33.804820 0.0041994599 3.540691e-01 4.983457e-01 15 40807642 40807659 18 + 1.510 1.443 -0.230
ENSG00000166140 E008 27.700248 0.0024843432 2.694094e-01 4.079213e-01 15 40807660 40807671 12 + 1.438 1.355 -0.287
ENSG00000166140 E009 24.467762 0.0012179595 1.298913e-01 2.340118e-01 15 40807672 40807676 5 + 1.411 1.295 -0.403
ENSG00000166140 E010 24.467762 0.0012179595 1.298913e-01 2.340118e-01 15 40807677 40807722 46 + 1.411 1.295 -0.403
ENSG00000166140 E011 2.907573 0.0054604473 8.257727e-01 8.903063e-01 15 40807723 40807733 11 + 0.505 0.545 0.187
ENSG00000166140 E012 2.690394 0.0058236994 9.388515e-01 9.656055e-01 15 40807734 40807734 1 + 0.505 0.520 0.071
ENSG00000166140 E013 13.299536 0.0014227840 5.737796e-01 6.997021e-01 15 40807735 40807756 22 + 1.037 1.099 0.223
ENSG00000166140 E014 25.683647 0.0008058344 9.090606e-02 1.765798e-01 15 40807757 40807762 6 + 1.229 1.372 0.500
ENSG00000166140 E015 31.434148 0.0008815192 1.948209e-01 3.197789e-01 15 40807763 40807767 5 + 1.351 1.450 0.342
ENSG00000166140 E016 55.842228 0.0089303874 9.749071e-02 1.866550e-01 15 40807768 40807791 24 + 1.578 1.698 0.408
ENSG00000166140 E017 65.331633 0.0004830850 5.582432e-02 1.193867e-01 15 40807792 40807821 30 + 1.658 1.761 0.348
ENSG00000166140 E018 76.435629 0.0003955942 9.712220e-02 1.860792e-01 15 40807822 40807868 47 + 1.744 1.825 0.276
ENSG00000166140 E019 18.356107 0.0009861089 5.598853e-02 1.196771e-01 15 40808044 40808075 32 + 1.329 1.167 -0.572
ENSG00000166140 E020 33.676988 0.0038790769 3.945166e-02 9.001780e-02 15 40808121 40808254 134 + 1.572 1.428 -0.493
ENSG00000166140 E021 30.237840 0.0011675888 1.522934e-02 4.100618e-02 15 40808255 40808378 124 + 1.538 1.372 -0.573
ENSG00000166140 E022 64.415740 0.0004090724 1.055841e-07 1.068115e-06 15 40808379 40808918 540 + 1.913 1.667 -0.830
ENSG00000166140 E023 26.286175 0.0010650174 2.099329e-04 1.006330e-03 15 40808919 40809012 94 + 1.545 1.281 -0.912
ENSG00000166140 E024 29.337469 0.0102894189 1.049474e-02 2.996666e-02 15 40809013 40809118 106 + 1.552 1.342 -0.722
ENSG00000166140 E025 83.896858 0.0004578214 4.240949e-01 5.670916e-01 15 40809119 40809155 37 + 1.819 1.857 0.128
ENSG00000166140 E026 123.928752 0.0007950536 9.591501e-03 2.776155e-02 15 40809156 40809240 85 + 1.930 2.035 0.354
ENSG00000166140 E027 15.016987 0.0086412894 6.707941e-01 7.771522e-01 15 40809241 40809407 167 + 1.152 1.108 -0.157
ENSG00000166140 E028 105.492222 0.0003382659 5.652295e-01 6.923673e-01 15 40809408 40809458 51 + 1.930 1.955 0.084
ENSG00000166140 E029 169.558389 0.0002926809 3.893555e-01 5.334575e-01 15 40809852 40809970 119 + 2.171 2.146 -0.083
ENSG00000166140 E030 7.172632 0.0028804602 1.517967e-03 5.694315e-03 15 40809971 40810070 100 + 1.099 0.719 -1.445
ENSG00000166140 E031 89.043639 0.0003572599 6.342914e-01 7.487886e-01 15 40810071 40810080 10 + 1.892 1.874 -0.061
ENSG00000166140 E032 177.427203 0.0002256970 7.369719e-01 8.272725e-01 15 40810081 40810216 136 + 2.161 2.174 0.041
ENSG00000166140 E033 152.214331 0.0002482974 8.849750e-01 9.304755e-01 15 40810649 40810757 109 + 2.102 2.108 0.023
ENSG00000166140 E034 9.560015 0.0017589260 2.364646e-06 1.810220e-05 15 40810758 40811074 317 + 1.282 0.792 -1.803
ENSG00000166140 E035 103.469543 0.0004556434 4.543500e-04 1.983941e-03 15 40812699 40812902 204 + 1.819 1.971 0.514
ENSG00000166140 E036 6.994626 0.0024010897 7.662856e-03 2.293409e-02 15 40813323 40813337 15 + 1.059 0.735 -1.237
ENSG00000166140 E037 134.916879 0.0007710915 2.477717e-01 3.833037e-01 15 40813338 40813417 80 + 2.021 2.066 0.151
ENSG00000166140 E038 18.279451 0.0023403499 5.522592e-01 6.815602e-01 15 40813418 40813662 245 + 1.243 1.190 -0.188
ENSG00000166140 E039 17.364890 0.0010687704 6.749949e-01 7.804054e-01 15 40813663 40813712 50 + 1.215 1.178 -0.130
ENSG00000166140 E040 125.763203 0.0002671988 1.078439e-01 2.023430e-01 15 40813713 40813811 99 + 1.975 2.037 0.207
ENSG00000166140 E041 122.269158 0.0017798585 1.107696e-02 3.135173e-02 15 40813943 40814070 128 + 1.924 2.037 0.378
ENSG00000166140 E042 52.495028 0.0052374928 1.607468e-01 2.760924e-01 15 40814071 40814147 77 + 1.572 1.672 0.342
ENSG00000166140 E043 109.952252 0.0044743492 1.659348e-01 2.829051e-01 15 40814148 40814212 65 + 1.910 1.986 0.254
ENSG00000166140 E044 206.866146 0.0016934374 4.209804e-03 1.373095e-02 15 40814213 40815084 872 + 2.158 2.261 0.343