ENSG00000166123

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000340124 ENSG00000166123 HEK293_OSMI2_2hA HEK293_TMG_2hB GPT2 protein_coding protein_coding 34.18545 49.79351 28.44746 2.175695 0.2918085 -0.8074405 17.601848 18.713957 18.9011791 5.911640 0.63048357 0.01435399 0.49492500 0.36953333 0.66433333 0.29480000 1.163912e-01 9.155722e-28 FALSE TRUE
ENST00000562132 ENSG00000166123 HEK293_OSMI2_2hA HEK293_TMG_2hB GPT2 protein_coding protein_coding 34.18545 49.79351 28.44746 2.175695 0.2918085 -0.8074405 5.100319 2.352971 8.3438680 1.378333 0.36541463 1.82184224 0.16368333 0.04636667 0.29343333 0.24706667 2.076919e-01 9.155722e-28 FALSE FALSE
MSTRG.12563.1 ENSG00000166123 HEK293_OSMI2_2hA HEK293_TMG_2hB GPT2 protein_coding   34.18545 49.79351 28.44746 2.175695 0.2918085 -0.8074405 8.264278 22.431527 0.0000000 3.009866 0.00000000 -11.13195511 0.24074167 0.45266667 0.00000000 -0.45266667 9.155722e-28 9.155722e-28 FALSE TRUE
MSTRG.12563.6 ENSG00000166123 HEK293_OSMI2_2hA HEK293_TMG_2hB GPT2 protein_coding   34.18545 49.79351 28.44746 2.175695 0.2918085 -0.8074405 2.021426 5.156031 0.6187121 2.566655 0.09711144 -3.03858471 0.06184583 0.10853333 0.02176667 -0.08676667 3.342652e-01 9.155722e-28 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000166123 E001 0.9492964 0.0168844553 2.880896e-01 4.286320e-01 16 46884308 46884334 27 + 0.398 0.213 -1.243
ENSG00000166123 E002 41.1369683 0.0430411457 3.333917e-03 1.124565e-02 16 46884362 46884467 106 + 1.764 1.466 -1.015
ENSG00000166123 E003 0.5848540 0.0347264249 3.342591e-01 4.779942e-01 16 46884468 46884517 50 + 0.001 0.214 8.874
ENSG00000166123 E004 35.7356958 0.0466830312 2.154260e-02 5.473100e-02 16 46884694 46884694 1 + 1.668 1.430 -0.813
ENSG00000166123 E005 41.3976829 0.0554908988 2.409845e-02 6.001470e-02 16 46884695 46884724 30 + 1.733 1.491 -0.822
ENSG00000166123 E006 75.9177860 0.0263227694 2.180991e-03 7.783408e-03 16 46884725 46884834 110 + 1.993 1.748 -0.827
ENSG00000166123 E007 147.9250870 0.0068831453 2.410117e-02 6.002070e-02 16 46884835 46884958 124 + 2.182 2.085 -0.324
ENSG00000166123 E008 1.6856657 0.0155836897 4.677343e-01 6.072345e-01 16 46884959 46885331 373 + 0.477 0.356 -0.656
ENSG00000166123 E009 1.8904376 0.1261160691 7.144781e-01 8.106784e-01 16 46885467 46885469 3 + 0.478 0.423 -0.281
ENSG00000166123 E010 3.8695692 0.0044688547 3.753600e-01 5.197893e-01 16 46885470 46885577 108 + 0.741 0.620 -0.507
ENSG00000166123 E011 1.1791606 0.0113239822 4.416193e-01 5.832604e-01 16 46885578 46885612 35 + 0.398 0.266 -0.827
ENSG00000166123 E012 219.1168651 0.0011855538 1.421931e-03 5.379432e-03 16 46897648 46897737 90 + 2.341 2.260 -0.270
ENSG00000166123 E013 279.1604876 0.0002249402 6.813239e-04 2.830649e-03 16 46900682 46900790 109 + 2.436 2.371 -0.216
ENSG00000166123 E014 356.3488579 0.0001702089 6.245517e-06 4.349819e-05 16 46906842 46906975 134 + 2.551 2.473 -0.259
ENSG00000166123 E015 526.3110369 0.0001333260 1.429200e-04 7.161763e-04 16 46909684 46909927 244 + 2.699 2.649 -0.163
ENSG00000166123 E016 15.3720492 0.0011974225 4.016968e-02 9.135355e-02 16 46915298 46916627 1330 + 1.279 1.109 -0.605
ENSG00000166123 E017 308.0355732 0.0026363761 4.420189e-02 9.876536e-02 16 46916628 46916707 80 + 2.467 2.419 -0.158
ENSG00000166123 E018 428.1790850 0.0006118897 1.290043e-01 2.327858e-01 16 46918621 46918757 137 + 2.586 2.569 -0.056
ENSG00000166123 E019 530.6753182 0.0001840078 7.568626e-01 8.418833e-01 16 46922242 46922416 175 + 2.658 2.667 0.032
ENSG00000166123 E020 7.0018200 0.0024457297 5.147770e-01 6.495036e-01 16 46923833 46924388 556 + 0.779 0.878 0.389
ENSG00000166123 E021 550.0663152 0.0001266682 9.802277e-04 3.892130e-03 16 46924389 46924544 156 + 2.626 2.698 0.240
ENSG00000166123 E022 438.8360715 0.0010049970 1.684864e-04 8.287269e-04 16 46926925 46927037 113 + 2.504 2.610 0.356
ENSG00000166123 E023 2161.8218368 0.0014032913 1.323811e-08 1.595166e-07 16 46928907 46931289 2383 + 3.201 3.301 0.331