ENSG00000166037

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000538658 ENSG00000166037 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP57 protein_coding protein_coding 22.61381 5.200255 37.28047 0.4047217 1.040587 2.839381 1.496198 0.50988919 2.504941 0.07920073 0.1420223 2.274249 0.07774583 0.09710000 0.06733333 -0.02976667 0.248601793 0.001057531 FALSE TRUE
ENST00000540830 ENSG00000166037 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP57 protein_coding nonsense_mediated_decay 22.61381 5.200255 37.28047 0.4047217 1.040587 2.839381 7.428129 2.88174603 9.030542 0.22770955 0.9118428 1.644468 0.41337500 0.56386667 0.24393333 -0.31993333 0.002152051 0.001057531 FALSE TRUE
ENST00000544522 ENSG00000166037 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP57 protein_coding protein_coding 22.61381 5.200255 37.28047 0.4047217 1.040587 2.839381 3.238856 0.51353576 6.999561 0.08628218 0.4918004 3.742964 0.12589583 0.09743333 0.18763333 0.09020000 0.004511640 0.001057531 FALSE FALSE
MSTRG.6204.4 ENSG00000166037 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP57 protein_coding   22.61381 5.200255 37.28047 0.4047217 1.040587 2.839381 6.251935 0.08382887 9.680261 0.08382887 0.8391904 6.690360 0.17185417 0.01416667 0.25880000 0.24463333 0.001057531 0.001057531 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000166037 E001 4.3503327 0.0036529211 2.234456e-01 3.545022e-01 11 95789965 95790142 178 + 0.589 0.806 0.905
ENSG00000166037 E002 4.3350062 0.0070200112 4.570300e-01 5.973958e-01 11 95790461 95790476 16 + 0.604 0.750 0.615
ENSG00000166037 E003 4.4801789 0.0071067767 5.105967e-01 6.457904e-01 11 95790477 95790478 2 + 0.619 0.750 0.551
ENSG00000166037 E004 6.8826132 0.0033394842 7.462508e-01 8.340658e-01 11 95790479 95790494 16 + 0.784 0.856 0.281
ENSG00000166037 E005 6.8740804 0.0024152546 7.452415e-01 8.333507e-01 11 95790495 95790497 3 + 0.784 0.856 0.281
ENSG00000166037 E006 8.0135888 0.0020538945 5.329425e-01 6.652107e-01 11 95790498 95790505 8 + 0.830 0.940 0.420
ENSG00000166037 E007 9.0100154 0.0018600721 5.844008e-01 7.083500e-01 11 95790506 95790512 7 + 0.880 0.977 0.365
ENSG00000166037 E008 10.1923878 0.0016228798 9.192979e-01 9.530058e-01 11 95790513 95790515 3 + 0.939 0.977 0.142
ENSG00000166037 E009 12.8455007 0.0013183005 6.740901e-01 7.796098e-01 11 95790516 95790521 6 + 1.037 1.011 -0.094
ENSG00000166037 E010 17.0601875 0.0010423099 6.555459e-01 7.654217e-01 11 95790522 95790530 9 + 1.147 1.125 -0.079
ENSG00000166037 E011 17.1290877 0.0010313196 4.515422e-01 5.924873e-01 11 95790531 95790532 2 + 1.156 1.099 -0.202
ENSG00000166037 E012 46.5573924 0.0005006945 3.540268e-01 4.983046e-01 11 95790533 95790591 59 + 1.569 1.534 -0.122
ENSG00000166037 E013 64.3530334 0.0003662436 3.201874e-01 4.632970e-01 11 95790592 95790658 67 + 1.705 1.675 -0.102
ENSG00000166037 E014 83.3657416 0.0003558446 2.136340e-01 3.428201e-01 11 95790659 95790743 85 + 1.817 1.781 -0.122
ENSG00000166037 E015 1.6316055 0.0559750372 7.437610e-01 8.323092e-01 11 95794221 95794359 139 + 0.322 0.407 0.501
ENSG00000166037 E016 10.6885748 0.0124855780 5.114774e-01 6.465053e-01 11 95795516 95795541 26 + 0.972 0.901 -0.267
ENSG00000166037 E017 10.0200720 0.0190098638 2.706638e-01 4.092920e-01 11 95795542 95795559 18 + 0.959 0.807 -0.580
ENSG00000166037 E018 40.3110131 0.0005353858 5.422331e-03 1.707577e-02 11 95799232 95799236 5 + 1.533 1.339 -0.668
ENSG00000166037 E019 109.3988853 0.0003216363 3.128357e-07 2.883418e-06 11 95799237 95799388 152 + 1.961 1.734 -0.763
ENSG00000166037 E020 0.7406253 0.0154738226 4.318603e-01 5.743676e-01 11 95812904 95812929 26 + 0.227 0.000 -10.082
ENSG00000166037 E021 0.2924217 0.0290785164 1.000000e+00   11 95812930 95812931 2 + 0.105 0.000 -8.789
ENSG00000166037 E022 45.2634232 0.0004993108 1.705384e-04 8.374065e-04 11 95812932 95812951 20 + 1.590 1.323 -0.918
ENSG00000166037 E023 59.5520414 0.0031461134 1.395515e-06 1.122674e-05 11 95812952 95812976 25 + 1.712 1.368 -1.176
ENSG00000166037 E024 124.3547502 0.0002980205 6.178261e-03 1.908327e-02 11 95812977 95813111 135 + 1.996 1.906 -0.305
ENSG00000166037 E025 102.7715955 0.0002997652 3.869215e-01 5.310906e-01 11 95813468 95813589 122 + 1.901 1.889 -0.040
ENSG00000166037 E026 1.8058358 0.0075987805 4.271439e-01 5.699835e-01 11 95815118 95815260 143 + 0.349 0.520 0.904
ENSG00000166037 E027 63.6764209 0.0010075960 1.164541e-01 2.148940e-01 11 95817787 95817819 33 + 1.706 1.638 -0.232
ENSG00000166037 E028 55.1348303 0.0004973056 1.881908e-02 4.893648e-02 11 95817820 95817836 17 + 1.653 1.524 -0.439
ENSG00000166037 E029 65.4298288 0.0003714778 2.195570e-02 5.558299e-02 11 95817837 95817903 67 + 1.725 1.614 -0.375
ENSG00000166037 E030 1.0675023 0.0114943724 9.306589e-01 9.603650e-01 11 95817904 95818032 129 + 0.261 0.248 -0.094
ENSG00000166037 E031 69.9509841 0.0006259136 6.232650e-01 7.398918e-01 11 95818827 95818904 78 + 1.734 1.734 0.000
ENSG00000166037 E032 78.3129273 0.0006837819 5.309823e-02 1.146555e-01 11 95821871 95821978 108 + 1.795 1.716 -0.268
ENSG00000166037 E033 24.5889353 0.0007918928 2.236256e-01 3.547283e-01 11 95821979 95822498 520 + 1.266 1.397 0.456
ENSG00000166037 E034 71.3424013 0.0003506537 1.043656e-01 1.971360e-01 11 95822499 95822576 78 + 1.753 1.689 -0.217
ENSG00000166037 E035 27.6867208 0.0143540540 2.242713e-01 3.555341e-01 11 95822577 95823215 639 + 1.318 1.468 0.519
ENSG00000166037 E036 31.0595020 0.0077240508 2.804586e-03 9.688732e-03 11 95825683 95827785 2103 + 1.433 1.149 -0.993
ENSG00000166037 E037 159.5996757 0.0026638328 5.676139e-01 6.943913e-01 11 95827786 95828027 242 + 2.089 2.092 0.011
ENSG00000166037 E038 149.7003736 0.0005187368 9.867226e-01 9.957716e-01 11 95829187 95829331 145 + 2.056 2.084 0.093
ENSG00000166037 E039 176.8082195 0.0002747346 1.093932e-01 2.046675e-01 11 95831026 95831267 242 + 2.116 2.198 0.272
ENSG00000166037 E040 306.5402951 0.0032377865 6.375805e-22 5.034920e-20 11 95831268 95832664 1397 + 2.292 2.622 1.101
ENSG00000166037 E041 16.0128491 0.0011473999 1.612850e-04 7.974978e-04 11 95832665 95834020 1356 + 1.031 1.410 1.340