ENSG00000166024

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000298999 ENSG00000166024 HEK293_OSMI2_2hA HEK293_TMG_2hB R3HCC1L protein_coding protein_coding 7.359605 5.462002 9.039298 0.3855975 0.3501661 0.725737 1.0271019 0.40235245 2.2865332 0.26784893 0.1854188 2.4775077 0.13036667 0.07730000 0.25540000 0.178100000 2.093951e-01 1.321286e-15 FALSE TRUE
ENST00000314594 ENSG00000166024 HEK293_OSMI2_2hA HEK293_TMG_2hB R3HCC1L protein_coding protein_coding 7.359605 5.462002 9.039298 0.3855975 0.3501661 0.725737 0.7339034 0.82938297 0.6774961 0.46455290 0.6774961 -0.2879777 0.11246667 0.15566667 0.07253333 -0.083133333 5.261545e-01 1.321286e-15 FALSE TRUE
ENST00000370584 ENSG00000166024 HEK293_OSMI2_2hA HEK293_TMG_2hB R3HCC1L protein_coding protein_coding 7.359605 5.462002 9.039298 0.3855975 0.3501661 0.725737 0.5548500 0.09455041 0.3353966 0.09455041 0.2154902 1.7240551 0.06773333 0.01806667 0.03706667 0.019000000 7.351255e-01 1.321286e-15 FALSE TRUE
ENST00000613938 ENSG00000166024 HEK293_OSMI2_2hA HEK293_TMG_2hB R3HCC1L protein_coding protein_coding 7.359605 5.462002 9.039298 0.3855975 0.3501661 0.725737 0.9717264 2.10803349 0.0000000 0.55259803 0.0000000 -7.7265816 0.18126250 0.37610000 0.00000000 -0.376100000 1.321286e-15 1.321286e-15 FALSE TRUE
MSTRG.4463.2 ENSG00000166024 HEK293_OSMI2_2hA HEK293_TMG_2hB R3HCC1L protein_coding   7.359605 5.462002 9.039298 0.3855975 0.3501661 0.725737 0.5361590 0.33133223 1.5264651 0.33133223 0.8238664 2.1703664 0.06387917 0.06336667 0.17093333 0.107566667 5.773444e-01 1.321286e-15 FALSE TRUE
MSTRG.4463.3 ENSG00000166024 HEK293_OSMI2_2hA HEK293_TMG_2hB R3HCC1L protein_coding   7.359605 5.462002 9.039298 0.3855975 0.3501661 0.725737 1.8968142 0.56953926 2.3777322 0.28477316 1.2444359 2.0426627 0.22470833 0.10030000 0.26553333 0.165233333 8.505940e-01 1.321286e-15 FALSE TRUE
MSTRG.4463.4 ENSG00000166024 HEK293_OSMI2_2hA HEK293_TMG_2hB R3HCC1L protein_coding   7.359605 5.462002 9.039298 0.3855975 0.3501661 0.725737 0.3460818 0.74835283 0.5367224 0.06076535 0.2934238 -0.4720608 0.05935833 0.13713333 0.05710000 -0.080033333 4.661538e-01 1.321286e-15 FALSE TRUE
MSTRG.4463.6 ENSG00000166024 HEK293_OSMI2_2hA HEK293_TMG_2hB R3HCC1L protein_coding   7.359605 5.462002 9.039298 0.3855975 0.3501661 0.725737 0.7814518 0.23323857 0.5036381 0.13384389 0.5036381 1.0783801 0.09370417 0.04393333 0.05336667 0.009433333 6.658919e-01 1.321286e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000166024 E001 0.0000000       10 98134624 98134640 17 +      
ENSG00000166024 E002 0.0000000       10 98134641 98134641 1 +      
ENSG00000166024 E003 0.1515154 0.0429246377 1.000000e+00   10 98134642 98134656 15 + 0.091 0.000 -9.168
ENSG00000166024 E004 0.4418608 0.0255011788 2.626909e-01 4.004893e-01 10 98134657 98134666 10 + 0.230 0.000 -12.491
ENSG00000166024 E005 10.0259837 0.0022308656 3.035959e-03 1.037153e-02 10 98134667 98134706 40 + 1.139 0.779 -1.351
ENSG00000166024 E006 1.6554517 0.0327856836 8.560803e-01 9.110508e-01 10 98134907 98135024 118 + 0.419 0.375 -0.244
ENSG00000166024 E007 0.1482932 0.0412253974 2.425280e-01   10 98152813 98152818 6 + 0.000 0.163 11.548
ENSG00000166024 E008 0.4438354 0.0784485110 2.624081e-01 4.001926e-01 10 98152819 98152852 34 + 0.091 0.279 1.958
ENSG00000166024 E009 0.5212538 0.0201518248 2.395117e-01 3.735456e-01 10 98153910 98154033 124 + 0.091 0.281 1.971
ENSG00000166024 E010 4.6395217 0.0036851613 3.514166e-02 8.191404e-02 10 98156093 98156147 55 + 0.848 0.515 -1.408
ENSG00000166024 E011 19.3521482 0.0014659660 1.725666e-02 4.551776e-02 10 98162883 98162975 93 + 1.368 1.153 -0.756
ENSG00000166024 E012 0.0000000       10 98163287 98163292 6 +      
ENSG00000166024 E013 23.9022090 0.0105692963 5.116625e-04 2.203422e-03 10 98163293 98163397 105 + 1.481 1.140 -1.191
ENSG00000166024 E014 11.2302492 0.1146081848 2.105803e-01 3.392276e-01 10 98186467 98186563 97 + 1.141 0.912 -0.838
ENSG00000166024 E015 101.5063398 0.0178695070 1.686101e-03 6.238439e-03 10 98208101 98208750 650 + 2.072 1.838 -0.787
ENSG00000166024 E016 163.5939618 0.0021809961 3.956467e-03 1.302055e-02 10 98208751 98209757 1007 + 2.242 2.134 -0.361
ENSG00000166024 E017 53.8508742 0.0005165528 6.933235e-01 7.943686e-01 10 98209758 98209899 142 + 1.723 1.728 0.016
ENSG00000166024 E018 1.4102740 0.0123295689 1.312284e-01 2.358600e-01 10 98211307 98211348 42 + 0.456 0.163 -2.028
ENSG00000166024 E019 62.2103000 0.0004285530 6.510152e-01 7.619750e-01 10 98231512 98231687 176 + 1.787 1.793 0.020
ENSG00000166024 E020 48.7546966 0.0005455035 3.204769e-01 4.636131e-01 10 98234446 98234516 71 + 1.672 1.708 0.123
ENSG00000166024 E021 55.1391921 0.0005050032 1.991627e-01 3.251784e-01 10 98235425 98235520 96 + 1.723 1.770 0.158
ENSG00000166024 E022 68.6541605 0.0003585509 3.297901e-02 7.776378e-02 10 98236024 98236164 141 + 1.801 1.877 0.253
ENSG00000166024 E023 175.6927256 0.0019445352 1.872283e-13 5.125698e-12 10 98244091 98244897 807 + 2.150 2.349 0.666