ENSG00000166012

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000393259 ENSG00000166012 HEK293_OSMI2_2hA HEK293_TMG_2hB TAF1D protein_coding nonsense_mediated_decay 76.47133 38.6689 115.2847 3.78028 3.375878 1.575708 5.913458 7.296538 5.583158 4.0787773 1.5110759 -0.385525 0.09600417 0.17460000 0.04776667 -0.126833333 1.814301e-01 2.230249e-05   FALSE
ENST00000448108 ENSG00000166012 HEK293_OSMI2_2hA HEK293_TMG_2hB TAF1D protein_coding protein_coding 76.47133 38.6689 115.2847 3.78028 3.375878 1.575708 7.005053 2.375747 13.928775 0.1464968 0.8385420 2.546591 0.08541667 0.06306667 0.12080000 0.057733333 3.827743e-03 2.230249e-05 FALSE TRUE
ENST00000525928 ENSG00000166012 HEK293_OSMI2_2hA HEK293_TMG_2hB TAF1D protein_coding retained_intron 76.47133 38.6689 115.2847 3.78028 3.375878 1.575708 8.765903 3.781179 15.443943 0.0830396 0.3028563 2.027257 0.11402083 0.09983333 0.13433333 0.034500000 2.020636e-01 2.230249e-05   FALSE
ENST00000529435 ENSG00000166012 HEK293_OSMI2_2hA HEK293_TMG_2hB TAF1D protein_coding retained_intron 76.47133 38.6689 115.2847 3.78028 3.375878 1.575708 7.988362 4.726823 13.038521 0.3474055 1.0213327 1.461895 0.10520000 0.12283333 0.11330000 -0.009533333 8.011378e-01 2.230249e-05 TRUE FALSE
ENST00000530769 ENSG00000166012 HEK293_OSMI2_2hA HEK293_TMG_2hB TAF1D protein_coding retained_intron 76.47133 38.6689 115.2847 3.78028 3.375878 1.575708 4.989936 1.255202 9.015724 0.2439299 0.4587681 2.834675 0.05816667 0.03216667 0.07810000 0.045933333 2.230249e-05 2.230249e-05 TRUE FALSE
ENST00000534079 ENSG00000166012 HEK293_OSMI2_2hA HEK293_TMG_2hB TAF1D protein_coding retained_intron 76.47133 38.6689 115.2847 3.78028 3.375878 1.575708 5.575684 2.943334 8.040425 0.2980719 0.8012889 1.446720 0.07508750 0.07843333 0.06963333 -0.008800000 8.732797e-01 2.230249e-05   FALSE
MSTRG.6184.3 ENSG00000166012 HEK293_OSMI2_2hA HEK293_TMG_2hB TAF1D protein_coding   76.47133 38.6689 115.2847 3.78028 3.375878 1.575708 10.446362 5.064578 15.986103 1.3301052 1.5803635 1.656361 0.13979167 0.13196667 0.13913333 0.007166667 9.157972e-01 2.230249e-05 TRUE TRUE
MSTRG.6184.9 ENSG00000166012 HEK293_OSMI2_2hA HEK293_TMG_2hB TAF1D protein_coding   76.47133 38.6689 115.2847 3.78028 3.375878 1.575708 4.751620 2.500182 4.739767 0.5010818 0.8111215 0.920065 0.06640000 0.06800000 0.04096667 -0.027033333 5.513771e-01 2.230249e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000166012 E001 6.1603993 0.0028066503 1.868497e-02 4.864249e-02 11 93729948 93730193 246 - 0.912 0.564 -1.427
ENSG00000166012 E002 2.3303118 0.0062510259 9.417443e-01 9.673728e-01 11 93730194 93730199 6 - 0.503 0.495 -0.039
ENSG00000166012 E003 21.3911996 0.0008540718 1.090816e-02 3.094146e-02 11 93730200 93730271 72 - 1.248 1.449 0.701
ENSG00000166012 E004 21.2031630 0.0008542878 2.501984e-03 8.768887e-03 11 93730272 93730280 9 - 1.228 1.466 0.827
ENSG00000166012 E005 21.3451134 0.0008412745 1.684200e-03 6.232745e-03 11 93730281 93730281 1 - 1.228 1.473 0.854
ENSG00000166012 E006 21.2042071 0.0008578669 1.372262e-03 5.216007e-03 11 93730282 93730282 1 - 1.223 1.473 0.872
ENSG00000166012 E007 119.7224944 0.0050332744 1.943314e-04 9.396741e-04 11 93730283 93730353 71 - 1.985 2.173 0.632
ENSG00000166012 E008 202.5124480 0.0123965860 3.305910e-03 1.116549e-02 11 93730354 93730402 49 - 2.208 2.401 0.647
ENSG00000166012 E009 163.8863845 0.0202030083 9.671975e-02 1.854600e-01 11 93730403 93730405 3 - 2.135 2.283 0.493
ENSG00000166012 E010 245.0355434 0.0158336062 1.026602e-01 1.945586e-01 11 93730406 93730447 42 - 2.315 2.445 0.433
ENSG00000166012 E011 28.6925943 0.0272921910 3.735013e-01 5.179386e-01 11 93730448 93730512 65 - 1.410 1.511 0.348
ENSG00000166012 E012 40.2420146 0.0253459617 5.257636e-01 6.590964e-01 11 93730513 93730666 154 - 1.602 1.555 -0.161
ENSG00000166012 E013 21.0325453 0.0281577955 2.711379e-01 4.098334e-01 11 93730667 93730676 10 - 1.347 1.238 -0.384
ENSG00000166012 E014 206.1448413 0.0071492891 6.245613e-03 1.925739e-02 11 93730677 93730681 5 - 2.235 2.381 0.488
ENSG00000166012 E015 271.0029560 0.0031313104 5.466693e-06 3.857308e-05 11 93730682 93730712 31 - 2.344 2.513 0.563
ENSG00000166012 E016 114.9490097 0.0032906653 5.105270e-01 6.457196e-01 11 93730713 93730978 266 - 2.041 2.022 -0.063
ENSG00000166012 E017 79.9979730 0.0003225169 1.627521e-01 2.787356e-01 11 93730979 93731145 167 - 1.894 1.840 -0.183
ENSG00000166012 E018 33.3579540 0.0008778507 2.790395e-01 4.187416e-01 11 93731146 93731149 4 - 1.524 1.458 -0.227
ENSG00000166012 E019 235.0574275 0.0007536365 2.174792e-09 3.026799e-08 11 93731150 93731160 11 - 2.281 2.449 0.561
ENSG00000166012 E020 320.8415891 0.0001461013 1.836164e-12 4.309411e-11 11 93731161 93731216 56 - 2.422 2.576 0.514
ENSG00000166012 E021 323.7771489 0.0001815201 9.321757e-05 4.901548e-04 11 93731753 93731799 47 - 2.450 2.540 0.301
ENSG00000166012 E022 18.6679115 0.0025533982 9.945091e-01 1.000000e+00 11 93731800 93732003 204 - 1.262 1.269 0.022
ENSG00000166012 E023 19.0008812 0.0009534571 7.958817e-01 8.696555e-01 11 93732004 93732243 240 - 1.272 1.256 -0.055
ENSG00000166012 E024 364.5724699 0.0001466004 1.044113e-08 1.281945e-07 11 93732244 93732291 48 - 2.489 2.610 0.402
ENSG00000166012 E025 57.4509287 0.0004241203 4.055133e-01 5.491927e-01 11 93732292 93732313 22 - 1.744 1.708 -0.122
ENSG00000166012 E026 53.0770627 0.0004807478 4.350541e-03 1.412433e-02 11 93732314 93732360 47 - 1.741 1.589 -0.517
ENSG00000166012 E027 140.0188463 0.0003052644 2.810265e-08 3.181335e-07 11 93732361 93732799 439 - 2.167 1.976 -0.637
ENSG00000166012 E028 54.9636187 0.0004259066 1.531334e-04 7.609635e-04 11 93732800 93732976 177 - 1.768 1.564 -0.693
ENSG00000166012 E029 37.8557473 0.0068919606 2.145122e-02 5.454053e-02 11 93732977 93733086 110 - 1.600 1.426 -0.597
ENSG00000166012 E030 284.1373670 0.0003293363 4.272233e-06 3.086575e-05 11 93733087 93733121 35 - 2.383 2.497 0.381
ENSG00000166012 E031 68.5183603 0.0050957584 3.157130e-05 1.868565e-04 11 93733122 93733227 106 - 1.871 1.614 -0.868
ENSG00000166012 E032 62.7418405 0.0004068355 5.066648e-10 7.920301e-09 11 93733228 93733304 77 - 1.849 1.511 -1.147
ENSG00000166012 E033 50.6422928 0.0007267172 1.054709e-09 1.557135e-08 11 93733305 93733349 45 - 1.766 1.388 -1.290
ENSG00000166012 E034 286.2474695 0.0004044143 1.511698e-03 5.673945e-03 11 93733350 93733397 48 - 2.399 2.481 0.274
ENSG00000166012 E035 123.6875362 0.0006730381 1.269879e-01 2.299489e-01 11 93733398 93733419 22 - 2.044 2.104 0.204
ENSG00000166012 E036 119.6009377 0.0020219492 1.006627e-01 1.914723e-01 11 93733420 93733465 46 - 2.069 2.006 -0.209
ENSG00000166012 E037 99.9961457 0.0005346650 2.387361e-01 3.726841e-01 11 93733466 93733505 40 - 1.986 1.946 -0.135
ENSG00000166012 E038 152.2539185 0.0002256902 2.310444e-03 8.183576e-03 11 93733506 93733673 168 - 2.180 2.088 -0.309
ENSG00000166012 E039 353.3798918 0.0039482754 1.916868e-12 4.485485e-11 11 93733674 93734624 951 - 2.583 2.315 -0.892
ENSG00000166012 E040 186.6525209 0.0001987956 6.200093e-02 1.299856e-01 11 93734625 93734660 36 - 2.221 2.280 0.198
ENSG00000166012 E041 198.7631423 0.0002174530 7.614086e-01 8.452873e-01 11 93734661 93734962 302 - 2.269 2.268 -0.004
ENSG00000166012 E042 208.8226937 0.0002230766 5.861395e-01 7.097626e-01 11 93734963 93735110 148 - 2.292 2.284 -0.027
ENSG00000166012 E043 231.8550654 0.0003150633 6.472563e-11 1.177913e-09 11 93735111 93735566 456 - 2.382 2.206 -0.586
ENSG00000166012 E044 98.9461112 0.0016702623 3.874055e-10 6.193486e-09 11 93735567 93735914 348 - 2.039 1.747 -0.983
ENSG00000166012 E045 121.2712645 0.0053652194 1.283861e-02 3.553718e-02 11 93735915 93736140 226 - 2.088 1.961 -0.426
ENSG00000166012 E046 262.2347052 0.0056379202 5.435312e-01 6.741182e-01 11 93736141 93736289 149 - 2.376 2.406 0.100
ENSG00000166012 E047 126.5962049 0.0055671499 2.637058e-01 4.016164e-01 11 93736290 93736304 15 - 2.087 2.032 -0.186
ENSG00000166012 E048 37.5370466 0.0005466361 3.190560e-07 2.935182e-06 11 93736305 93736693 389 - 1.637 1.281 -1.226
ENSG00000166012 E049 182.6382315 0.0073007085 2.158834e-01 3.454583e-01 11 93736694 93736751 58 - 2.247 2.185 -0.205
ENSG00000166012 E050 45.8628132 0.0014070913 5.603896e-08 5.973002e-07 11 93736752 93737063 312 - 1.717 1.359 -1.226
ENSG00000166012 E051 140.1719587 0.0044212015 6.258753e-01 7.419239e-01 11 93737064 93737088 25 - 2.120 2.101 -0.066
ENSG00000166012 E052 173.6813815 0.0092190872 8.698208e-01 9.202727e-01 11 93737089 93737155 67 - 2.209 2.203 -0.019
ENSG00000166012 E053 174.5620535 0.0040757483 9.938824e-01 1.000000e+00 11 93737156 93737239 84 - 2.209 2.210 0.003
ENSG00000166012 E054 318.5964064 0.0049418414 1.485980e-02 4.017372e-02 11 93738109 93738440 332 - 2.499 2.400 -0.330
ENSG00000166012 E055 129.0773689 0.0002688722 5.316280e-05 2.975693e-04 11 93738441 93738499 59 - 2.118 1.979 -0.466
ENSG00000166012 E056 7.5400475 0.0127682679 3.669394e-05 2.134153e-04 11 93738967 93739236 270 - 1.023 0.315 -3.164
ENSG00000166012 E057 107.9319316 0.0002949916 9.084361e-06 6.095289e-05 11 93739237 93739280 44 - 2.048 1.878 -0.571
ENSG00000166012 E058 104.9650370 0.0032187472 9.932062e-04 3.935001e-03 11 93739281 93739331 51 - 2.033 1.876 -0.525
ENSG00000166012 E059 115.5942972 0.0134779726 1.005775e-02 2.890228e-02 11 93741322 93741495 174 - 2.079 1.903 -0.592
ENSG00000166012 E060 1.2253605 0.0140569261 3.149277e-01 4.576719e-01 11 93742703 93742898 196 - 0.379 0.185 -1.386
ENSG00000166012 E061 0.4482035 0.0264145544 3.763792e-01 5.207098e-01 11 93766187 93766226 40 - 0.203 0.001 -8.960
ENSG00000166012 E062 1.6984268 0.0271825859 4.085553e-01 5.521679e-01 11 93784304 93784521 218 - 0.341 0.497 0.842