ENSG00000166004

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000325212 ENSG00000166004 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP295 protein_coding protein_coding 5.777141 2.123619 7.446038 0.3412621 0.2281737 1.805107 1.2167151 0.21926335 1.5198454 0.21926335 0.54830959 2.7383082 0.19637917 0.10963333 0.20126667 0.09163333 3.725430e-01 1.504505e-05 FALSE TRUE
ENST00000530425 ENSG00000166004 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP295 protein_coding protein_coding 5.777141 2.123619 7.446038 0.3412621 0.2281737 1.805107 0.3336235 0.08128048 0.7502353 0.08128048 0.23318399 3.0580678 0.05059583 0.02936667 0.09956667 0.07020000 3.164541e-01 1.504505e-05 FALSE TRUE
ENST00000531404 ENSG00000166004 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP295 protein_coding protein_coding 5.777141 2.123619 7.446038 0.3412621 0.2281737 1.805107 0.8446113 0.60778994 0.8088853 0.25179577 0.09733629 0.4065450 0.20328750 0.27143333 0.10880000 -0.16263333 7.067430e-02 1.504505e-05 FALSE TRUE
ENST00000531700 ENSG00000166004 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP295 protein_coding protein_coding 5.777141 2.123619 7.446038 0.3412621 0.2281737 1.805107 0.8633293 0.65593973 0.7959127 0.16316262 0.40800884 0.2752319 0.20237083 0.33783333 0.10773333 -0.23010000 4.507275e-01 1.504505e-05 FALSE TRUE
MSTRG.6180.10 ENSG00000166004 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP295 protein_coding   5.777141 2.123619 7.446038 0.3412621 0.2281737 1.805107 0.1170786 0.25838067 0.1377371 0.14115395 0.04349995 -0.8612483 0.03033333 0.10856667 0.01840000 -0.09016667 3.122068e-02 1.504505e-05 FALSE TRUE
MSTRG.6180.5 ENSG00000166004 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP295 protein_coding   5.777141 2.123619 7.446038 0.3412621 0.2281737 1.805107 0.7093728 0.00000000 1.6608213 0.00000000 0.41581574 7.3844136 0.08025417 0.00000000 0.22566667 0.22566667 1.504505e-05 1.504505e-05 FALSE TRUE
MSTRG.6180.9 ENSG00000166004 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP295 protein_coding   5.777141 2.123619 7.446038 0.3412621 0.2281737 1.805107 1.1428856 0.29047513 1.3450861 0.15122963 0.78310117 2.1730670 0.16591667 0.13666667 0.18166667 0.04500000 9.986219e-01 1.504505e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000166004 E001 0.9641468 0.0122084701 9.222277e-01 9.549469e-01 11 93661658 93661660 3 + 0.253 0.222 -0.244
ENSG00000166004 E002 1.1113958 0.0116776969 7.728326e-01 8.533744e-01 11 93661661 93661666 6 + 0.290 0.222 -0.507
ENSG00000166004 E003 1.2586448 0.0162144457 6.521991e-01 7.629246e-01 11 93661667 93661681 15 + 0.324 0.223 -0.729
ENSG00000166004 E004 4.3180555 0.0035839567 5.522300e-01 6.815392e-01 11 93661682 93661705 24 + 0.681 0.565 -0.507
ENSG00000166004 E005 10.3890469 0.0016512803 7.476800e-03 2.245351e-02 11 93661706 93661774 69 + 1.047 0.638 -1.601
ENSG00000166004 E006 19.1065810 0.0009594894 1.662557e-05 1.050098e-04 11 93666682 93666815 134 + 1.301 0.754 -2.022
ENSG00000166004 E007 21.0871591 0.0101713590 1.160976e-03 4.508793e-03 11 93667607 93667807 201 + 1.331 0.922 -1.471
ENSG00000166004 E008 12.5701089 0.0013538164 9.668318e-03 2.794611e-02 11 93668808 93668932 125 + 1.115 0.754 -1.363
ENSG00000166004 E009 11.0751142 0.0056011578 4.323007e-02 9.697358e-02 11 93669677 93669770 94 + 1.053 0.755 -1.135
ENSG00000166004 E010 0.2966881 0.0272175051 1.000000e+00   11 93672043 93672093 51 + 0.120 0.000 -8.890
ENSG00000166004 E011 13.9868274 0.0033901114 1.046456e-03 4.119951e-03 11 93675571 93675666 96 + 1.165 0.700 -1.763
ENSG00000166004 E012 5.7235009 0.0244654993 3.955162e-03 1.301693e-02 11 93679412 93679415 4 + 0.837 0.223 -3.131
ENSG00000166004 E013 19.2503869 0.0010758541 7.560483e-08 7.859476e-07 11 93679416 93679552 137 + 1.318 0.565 -2.889
ENSG00000166004 E014 23.2871578 0.0008193586 2.844946e-08 3.216942e-07 11 93683559 93683742 184 + 1.394 0.700 -2.567
ENSG00000166004 E015 13.5559144 0.0012506788 1.189384e-03 4.605333e-03 11 93683964 93684128 165 + 1.156 0.700 -1.730
ENSG00000166004 E016 19.8508784 0.0010122560 1.093958e-04 5.652839e-04 11 93687644 93687865 222 + 1.311 0.846 -1.695
ENSG00000166004 E017 0.0000000       11 93691681 93691682 2 +      
ENSG00000166004 E018 11.2608892 0.0015010490 1.295610e-04 6.568790e-04 11 93691683 93691704 22 + 1.099 0.478 -2.528
ENSG00000166004 E019 15.5351268 0.0011872289 3.334969e-05 1.960589e-04 11 93691705 93691775 71 + 1.222 0.638 -2.230
ENSG00000166004 E020 16.5053888 0.0017205686 6.228847e-05 3.427250e-04 11 93691927 93692030 104 + 1.242 0.700 -2.038
ENSG00000166004 E021 11.7110528 0.0021667843 6.850204e-03 2.083736e-02 11 93695497 93695529 33 + 1.094 0.700 -1.508
ENSG00000166004 E022 14.0134780 0.0013000923 4.427354e-02 9.888693e-02 11 93695530 93695634 105 + 1.146 0.886 -0.958
ENSG00000166004 E023 6.2538392 0.0026249047 1.203442e-01 2.204683e-01 11 93695635 93695673 39 + 0.836 0.565 -1.132
ENSG00000166004 E024 10.8770033 0.0016711221 3.858135e-02 8.841642e-02 11 93696320 93696417 98 + 1.053 0.754 -1.138
ENSG00000166004 E025 16.5799393 0.0010936856 2.216801e-04 1.056652e-03 11 93696682 93696854 173 + 1.238 0.754 -1.802
ENSG00000166004 E026 11.6401885 0.0016647101 5.567294e-02 1.191356e-01 11 93696855 93696937 83 + 1.071 0.803 -1.010
ENSG00000166004 E027 144.0603401 0.0299978558 9.928300e-04 3.933675e-03 11 93696938 93698907 1970 + 2.132 1.841 -0.976
ENSG00000166004 E028 66.1786441 0.0095238433 1.644618e-01 2.809830e-01 11 93698908 93699574 667 + 1.773 1.655 -0.399
ENSG00000166004 E029 53.6447072 0.0042594964 9.226055e-01 9.551815e-01 11 93699575 93700186 612 + 1.658 1.637 -0.071
ENSG00000166004 E030 26.5867006 0.0007882112 6.515908e-02 1.353011e-01 11 93702460 93702637 178 + 1.328 1.454 0.436
ENSG00000166004 E031 16.9856940 0.0010917351 1.090559e-01 2.041532e-01 11 93702776 93702919 144 + 1.146 1.280 0.475
ENSG00000166004 E032 35.9347882 0.0006165543 8.445375e-01 9.032270e-01 11 93706745 93706897 153 + 1.486 1.483 -0.010
ENSG00000166004 E033 28.3291875 0.0011305699 4.486558e-01 5.899257e-01 11 93721312 93721412 101 + 1.402 1.324 -0.273
ENSG00000166004 E034 24.4221497 0.0008310228 4.704469e-01 6.096751e-01 11 93721954 93722050 97 + 1.344 1.264 -0.277
ENSG00000166004 E035 6.6108630 0.1163811794 9.371366e-01 9.644910e-01 11 93722502 93723040 539 + 0.794 0.820 0.102
ENSG00000166004 E036 14.2784870 0.0012746326 9.485161e-01 9.717313e-01 11 93723041 93723052 12 + 1.115 1.092 -0.083
ENSG00000166004 E037 43.0310367 0.0005251877 9.445538e-02 1.820634e-01 11 93723053 93723289 237 + 1.541 1.628 0.297
ENSG00000166004 E038 1.0330470 0.0118579658 1.867387e-01 3.096391e-01 11 93723399 93724253 855 + 0.324 0.000 -10.564
ENSG00000166004 E039 27.9561585 0.0007616378 8.030497e-04 3.269970e-03 11 93724254 93724375 122 + 1.318 1.545 0.784
ENSG00000166004 E040 35.9958625 0.0015070549 5.765236e-02 1.225983e-01 11 93725651 93725831 181 + 1.456 1.570 0.391
ENSG00000166004 E041 104.5386571 0.0003184031 1.542347e-08 1.835614e-07 11 93726976 93727637 662 + 1.887 2.084 0.663
ENSG00000166004 E042 39.7386791 0.0087790370 8.370351e-06 5.660317e-05 11 93728681 93728821 141 + 1.446 1.751 1.038
ENSG00000166004 E043 35.3273742 0.0152007490 5.155338e-05 2.895018e-04 11 93729434 93729530 97 + 1.391 1.712 1.099
ENSG00000166004 E044 6.6838526 0.0230148915 1.764440e-01 2.966182e-01 11 93729611 93729613 3 + 0.772 0.954 0.705
ENSG00000166004 E045 46.0051750 0.0079792200 2.235992e-07 2.123531e-06 11 93729614 93729781 168 + 1.492 1.825 1.131
ENSG00000166004 E046 39.7829252 0.0024662620 1.409830e-10 2.426089e-09 11 93729870 93729969 100 + 1.413 1.792 1.293
ENSG00000166004 E047 33.4812441 0.0006780101 7.819888e-08 8.106897e-07 11 93730049 93730148 100 + 1.362 1.691 1.128
ENSG00000166004 E048 14.9269248 0.0142728172 5.258047e-03 1.663279e-02 11 93730231 93730358 128 + 1.053 1.335 1.000