ENSG00000165983

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000378000 ENSG00000165983 HEK293_OSMI2_2hA HEK293_TMG_2hB PTER protein_coding protein_coding 5.530681 1.687549 9.686795 0.0772187 0.2488455 2.514055 2.8147353 0.83478526 4.656546 0.13867059 0.2955990 2.465698 0.52072917 0.49203333 0.48246667 -0.009566667 1.0000000 0.0297329 FALSE  
ENST00000423462 ENSG00000165983 HEK293_OSMI2_2hA HEK293_TMG_2hB PTER protein_coding protein_coding 5.530681 1.687549 9.686795 0.0772187 0.2488455 2.514055 0.2885407 0.13287328 0.540194 0.13287328 0.1834795 1.945204 0.06450000 0.07533333 0.05483333 -0.020500000 0.8330428 0.0297329 FALSE  
ENST00000535784 ENSG00000165983 HEK293_OSMI2_2hA HEK293_TMG_2hB PTER protein_coding protein_coding 5.530681 1.687549 9.686795 0.0772187 0.2488455 2.514055 0.2399418 0.26075235 0.000000 0.26075235 0.0000000 -4.758902 0.04789167 0.17006667 0.00000000 -0.170066667 0.5572720 0.0297329 FALSE  
MSTRG.3604.2 ENSG00000165983 HEK293_OSMI2_2hA HEK293_TMG_2hB PTER protein_coding   5.530681 1.687549 9.686795 0.0772187 0.2488455 2.514055 0.6067788 0.05139212 1.360846 0.05139212 0.2019734 4.480869 0.07532500 0.02913333 0.14136667 0.112233333 0.1396495 0.0297329 FALSE  
MSTRG.3604.4 ENSG00000165983 HEK293_OSMI2_2hA HEK293_TMG_2hB PTER protein_coding   5.530681 1.687549 9.686795 0.0772187 0.2488455 2.514055 1.3576130 0.21509583 3.107711 0.18967589 0.3848242 3.791876 0.19906667 0.12180000 0.31916667 0.197366667 0.2374364 0.0297329 FALSE  
MSTRG.3604.5 ENSG00000165983 HEK293_OSMI2_2hA HEK293_TMG_2hB PTER protein_coding   5.530681 1.687549 9.686795 0.0772187 0.2488455 2.514055 0.1074656 0.17180582 0.000000 0.13280809 0.0000000 -4.184326 0.05976250 0.09976667 0.00000000 -0.099766667 0.0297329 0.0297329 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000165983 E001 2.2259387 0.0556029985 4.006667e-01 5.443321e-01 10 16436943 16436981 39 + 0.417 0.586 0.826
ENSG00000165983 E002 3.3008279 0.0983411755 3.476863e-01 4.918785e-01 10 16436982 16436983 2 + 0.525 0.719 0.853
ENSG00000165983 E003 10.0726986 0.0042928592 5.285947e-01 6.615142e-01 10 16436984 16436998 15 + 0.943 1.017 0.275
ENSG00000165983 E004 13.6304076 0.0014878731 5.135913e-01 6.483876e-01 10 16436999 16437009 11 + 1.057 1.124 0.242
ENSG00000165983 E005 23.4485751 0.0008677041 5.904847e-01 7.133419e-01 10 16437010 16437047 38 + 1.286 1.327 0.145
ENSG00000165983 E006 22.9429948 0.0096047577 9.844361e-02 1.881336e-01 10 16437357 16437490 134 + 1.255 1.406 0.528
ENSG00000165983 E007 10.8903290 0.0016214765 3.994595e-02 9.093644e-02 10 16467132 16467210 79 + 1.028 0.728 -1.155
ENSG00000165983 E008 0.2214452 0.0387031052 7.799943e-02   10 16484335 16484336 2 + 0.000 0.237 11.793
ENSG00000165983 E009 74.6043548 0.0003601697 8.240071e-05 4.393630e-04 10 16484337 16484690 354 + 1.815 1.587 -0.773
ENSG00000165983 E010 52.0904924 0.0005016123 3.690096e-02 8.527430e-02 10 16484691 16484816 126 + 1.648 1.507 -0.484
ENSG00000165983 E011 78.4641340 0.0004093323 4.351893e-02 9.749802e-02 10 16486352 16486617 266 + 1.823 1.713 -0.371
ENSG00000165983 E012 0.3030308 0.3642311101 1.000000e+00   10 16486618 16486792 175 + 0.112 0.000 -9.219
ENSG00000165983 E013 48.6720939 0.0025793500 2.812396e-02 6.825957e-02 10 16505020 16505160 141 + 1.628 1.465 -0.556
ENSG00000165983 E014 51.1817587 0.0224277653 2.385362e-01 3.724397e-01 10 16511046 16511134 89 + 1.644 1.528 -0.394
ENSG00000165983 E015 153.5217094 0.0044198361 4.273058e-02 9.605329e-02 10 16511135 16512140 1006 + 2.106 2.009 -0.325
ENSG00000165983 E016 27.8530872 0.0084768601 9.230332e-02 1.787190e-01 10 16512141 16512222 82 + 1.327 1.468 0.489
ENSG00000165983 E017 125.8049747 0.0003841893 1.730077e-02 4.560490e-02 10 16512223 16512904 682 + 1.986 2.067 0.271
ENSG00000165983 E018 81.7685981 0.0004619327 2.650451e-13 7.099108e-12 10 16512905 16513775 871 + 1.744 2.045 1.012