ENSG00000165934

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
MSTRG.10098.5 ENSG00000165934 HEK293_OSMI2_2hA HEK293_TMG_2hB CPSF2 protein_coding   24.32247 6.551559 39.30843 0.4155044 1.50472 2.583095 11.86157 1.170423 20.90878 0.5853632 0.9870280 4.147423 0.3754000 0.1701667 0.5316333 0.3614667 0.326164385 7.257589e-05 FALSE TRUE
MSTRG.10098.8 ENSG00000165934 HEK293_OSMI2_2hA HEK293_TMG_2hB CPSF2 protein_coding   24.32247 6.551559 39.30843 0.4155044 1.50472 2.583095 10.76492 5.001654 16.11519 0.2343678 0.6386627 1.685957 0.5212083 0.7700000 0.4106333 -0.3593667 0.003607306 7.257589e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000165934 E001 1.3964557 0.0098580548 8.267679e-01 8.910142e-01 14 92121969 92121971 3 + 0.305 0.390 0.517
ENSG00000165934 E002 4.6774148 0.0769061849 2.330856e-01 3.660805e-01 14 92121972 92121982 11 + 0.705 0.504 -0.893
ENSG00000165934 E003 8.6855345 0.0028168530 1.950870e-03 7.074239e-03 14 92121983 92121984 2 + 0.954 0.503 -1.873
ENSG00000165934 E004 62.6770015 0.0007288551 1.450592e-07 1.428476e-06 14 92121985 92122103 119 + 1.742 1.479 -0.897
ENSG00000165934 E005 58.9251752 0.0143409896 1.585086e-05 1.005996e-04 14 92122104 92122128 25 + 1.722 1.403 -1.090
ENSG00000165934 E006 3.9858693 0.0039319742 1.610053e-02 4.295990e-02 14 92122129 92122351 223 + 0.680 0.238 -2.377
ENSG00000165934 E007 1.1876829 0.0108862634 6.141259e-01 7.326791e-01 14 92124289 92124366 78 + 0.305 0.237 -0.485
ENSG00000165934 E008 85.9372798 0.0349925141 6.622816e-03 2.024678e-02 14 92126122 92126180 59 + 1.870 1.663 -0.700
ENSG00000165934 E009 2.3906672 0.1027162934 2.021250e-01 3.288531e-01 14 92129136 92129278 143 + 0.502 0.238 -1.579
ENSG00000165934 E010 153.4591496 0.0009340558 8.046471e-09 1.009122e-07 14 92130951 92131133 183 + 2.114 1.954 -0.539
ENSG00000165934 E011 154.2971524 0.0009437731 1.217125e-05 7.927822e-05 14 92134011 92134170 160 + 2.107 2.010 -0.326
ENSG00000165934 E012 139.5691168 0.0002295073 2.550068e-07 2.394680e-06 14 92134250 92134355 106 + 2.068 1.939 -0.434
ENSG00000165934 E013 162.3374984 0.0002060574 1.002237e-08 1.235494e-07 14 92135367 92135496 130 + 2.136 2.000 -0.455
ENSG00000165934 E014 151.9219992 0.0002151637 1.552377e-05 9.872871e-05 14 92138232 92138347 116 + 2.098 2.013 -0.285
ENSG00000165934 E015 215.6440738 0.0024885974 3.899206e-05 2.253556e-04 14 92142164 92142351 188 + 2.248 2.164 -0.281
ENSG00000165934 E016 76.4165392 0.0026005810 5.860057e-03 1.824527e-02 14 92143004 92143007 4 + 1.801 1.717 -0.284
ENSG00000165934 E017 255.9450832 0.0047375956 4.426889e-03 1.433633e-02 14 92143008 92143294 287 + 2.315 2.272 -0.145
ENSG00000165934 E018 0.3030308 0.3710488547 1.000000e+00   14 92154021 92154357 337 + 0.111 0.001 -7.335
ENSG00000165934 E019 145.4906551 0.0005277215 1.695822e-03 6.270242e-03 14 92154358 92154458 101 + 2.072 2.028 -0.148
ENSG00000165934 E020 135.2456822 0.0132930087 1.838881e-01 3.061038e-01 14 92155123 92155178 56 + 2.033 2.023 -0.034
ENSG00000165934 E021 180.2998742 0.0062279754 2.520492e-01 3.883690e-01 14 92155179 92155323 145 + 2.151 2.173 0.073
ENSG00000165934 E022 162.1274839 0.0024605863 2.043187e-01 3.315594e-01 14 92156479 92156631 153 + 2.104 2.130 0.086
ENSG00000165934 E023 229.3261536 0.0004712982 3.769337e-01 5.212713e-01 14 92157659 92157884 226 + 2.250 2.302 0.173
ENSG00000165934 E024 306.3517817 0.0003387354 4.283971e-01 5.711761e-01 14 92158983 92159282 300 + 2.366 2.464 0.327
ENSG00000165934 E025 194.7462405 0.0002627944 1.438916e-04 7.204788e-04 14 92161112 92161246 135 + 2.147 2.337 0.636
ENSG00000165934 E026 825.7779814 0.0128377304 1.340161e-07 1.328708e-06 14 92161652 92164745 3094 + 2.734 3.051 1.057
ENSG00000165934 E027 49.7179212 0.0276648548 7.277387e-05 3.935191e-04 14 92164746 92168551 3806 + 1.467 1.943 1.614
ENSG00000165934 E028 26.3356532 0.0391371410 1.968649e-14 6.207635e-13 14 92168552 92172145 3594 + 0.910 1.899 3.454