ENSG00000165915

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000354884 ENSG00000165915 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC39A13 protein_coding protein_coding 24.91167 36.50827 16.29767 1.97069 1.124609 -1.163068 8.427636 14.161403 4.2998666 1.05583769 0.5360067 -1.71726746 0.33276250 0.38706667 0.26256667 -0.12450000 2.174701e-03 1.587346e-10 FALSE TRUE
ENST00000362021 ENSG00000165915 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC39A13 protein_coding protein_coding 24.91167 36.50827 16.29767 1.97069 1.124609 -1.163068 6.596498 11.492395 4.4402074 0.46514586 0.2825937 -1.36998980 0.24599583 0.31653333 0.27660000 -0.03993333 7.066307e-01 1.587346e-10 FALSE TRUE
ENST00000524928 ENSG00000165915 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC39A13 protein_coding protein_coding 24.91167 36.50827 16.29767 1.97069 1.124609 -1.163068 2.373612 1.708128 2.1097748 0.18661873 0.1055026 0.30307317 0.10572917 0.04650000 0.12983333 0.08333333 1.587346e-10 1.587346e-10 FALSE TRUE
ENST00000527829 ENSG00000165915 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC39A13 protein_coding processed_transcript 24.91167 36.50827 16.29767 1.97069 1.124609 -1.163068 1.601141 4.114005 0.6923032 0.09720992 0.3548413 -2.55388002 0.05437083 0.11326667 0.04036667 -0.07290000 4.208771e-01 1.587346e-10   FALSE
ENST00000528979 ENSG00000165915 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC39A13 protein_coding processed_transcript 24.91167 36.50827 16.29767 1.97069 1.124609 -1.163068 1.211204 0.857954 0.9946402 0.24029282 0.1515224 0.21098844 0.05325833 0.02356667 0.06096667 0.03740000 6.604882e-02 1.587346e-10 FALSE FALSE
ENST00000531974 ENSG00000165915 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC39A13 protein_coding protein_coding 24.91167 36.50827 16.29767 1.97069 1.124609 -1.163068 2.415293 1.579620 1.6012358 0.49044257 0.2374351 0.01948599 0.11027917 0.04213333 0.09720000 0.05506667 2.847370e-02 1.587346e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000165915 E001 0.0000000       11 47407132 47407533 402 +      
ENSG00000165915 E002 2.3335341 0.0063684693 4.823228e-05 2.728415e-04 11 47408533 47408583 51 + 0.853 0.210 -3.298
ENSG00000165915 E003 2.4828714 0.0059314782 1.074765e-03 4.217471e-03 11 47408584 47408584 1 + 0.820 0.309 -2.437
ENSG00000165915 E004 2.4839156 0.0090106014 5.945498e-03 1.846486e-02 11 47408585 47408589 5 + 0.786 0.351 -2.037
ENSG00000165915 E005 9.6579622 0.0017565743 4.488781e-01 5.901005e-01 11 47408590 47408604 15 + 1.029 0.949 -0.298
ENSG00000165915 E006 31.4953007 0.0007589891 6.701800e-02 1.384116e-01 11 47408605 47408627 23 + 1.534 1.417 -0.401
ENSG00000165915 E007 33.3367206 0.0007365575 7.116108e-02 1.452627e-01 11 47408628 47408630 3 + 1.553 1.441 -0.385
ENSG00000165915 E008 72.3161643 0.0003830798 2.160968e-01 3.457093e-01 11 47408631 47408662 32 + 1.838 1.787 -0.173
ENSG00000165915 E009 0.1482932 0.0415738058 1.000000e+00   11 47409591 47409663 73 + 0.000 0.082 8.764
ENSG00000165915 E010 0.0000000       11 47409821 47409965 145 +      
ENSG00000165915 E011 0.1515154 0.0428237676 1.936531e-01   11 47410066 47410084 19 + 0.179 0.000 -11.172
ENSG00000165915 E012 0.3729606 0.0294541632 5.069816e-01 6.426025e-01 11 47410085 47410086 2 + 0.179 0.082 -1.295
ENSG00000165915 E013 236.5450639 0.0012034203 3.061413e-01 4.483110e-01 11 47410087 47410395 309 + 2.327 2.304 -0.078
ENSG00000165915 E014 145.7243735 0.0018284586 4.510390e-01 5.920402e-01 11 47411926 47412039 114 + 2.077 2.111 0.115
ENSG00000165915 E015 14.0274593 0.0143035237 3.681490e-04 1.651075e-03 11 47412040 47412301 262 + 1.351 0.982 -1.319
ENSG00000165915 E016 7.8829270 0.1041355885 2.241874e-02 5.654741e-02 11 47412302 47412345 44 + 1.139 0.754 -1.452
ENSG00000165915 E017 133.9493225 0.0031694597 2.359191e-01 3.694438e-01 11 47412346 47412467 122 + 2.022 2.079 0.192
ENSG00000165915 E018 156.2736002 0.0006121399 1.406324e-01 2.488872e-01 11 47413400 47413507 108 + 2.090 2.144 0.183
ENSG00000165915 E019 166.5327704 0.0002674129 5.522865e-01 6.815709e-01 11 47413597 47413686 90 + 2.141 2.164 0.079
ENSG00000165915 E020 24.4190267 0.0012888326 4.548238e-14 1.356929e-12 11 47413687 47413880 194 + 1.667 1.142 -1.820
ENSG00000165915 E021 49.9145443 0.0085377826 3.455910e-10 5.564911e-09 11 47413881 47414295 415 + 1.904 1.495 -1.386
ENSG00000165915 E022 32.0872875 0.0013432070 1.687479e-06 1.334089e-05 11 47414296 47414424 129 + 1.657 1.354 -1.039
ENSG00000165915 E023 121.7826561 0.0002705008 2.661372e-01 4.042859e-01 11 47414425 47414436 12 + 2.050 2.016 -0.114
ENSG00000165915 E024 137.7471275 0.0002458735 3.348618e-01 4.786009e-01 11 47414437 47414475 39 + 2.097 2.070 -0.090
ENSG00000165915 E025 14.0502047 0.0012834134 3.610934e-07 3.285635e-06 11 47414476 47414776 301 + 1.406 0.959 -1.598
ENSG00000165915 E026 155.6992537 0.0002808038 9.852197e-01 9.947765e-01 11 47414777 47414861 85 + 2.124 2.129 0.015
ENSG00000165915 E027 95.1464868 0.0003209101 8.442350e-02 1.664787e-01 11 47414862 47414905 44 + 1.857 1.934 0.260
ENSG00000165915 E028 66.9400394 0.0016440755 4.918109e-01 6.290625e-01 11 47414906 47414909 4 + 1.733 1.774 0.140
ENSG00000165915 E029 10.8498177 0.0343208903 1.305635e-03 4.995732e-03 11 47414910 47415038 129 + 1.287 0.888 -1.449
ENSG00000165915 E030 6.0547970 0.0026241893 7.351574e-04 3.025840e-03 11 47415039 47415059 21 + 1.069 0.656 -1.604
ENSG00000165915 E031 159.1951806 0.0002475169 1.902919e-02 4.939808e-02 11 47415060 47415159 100 + 2.079 2.160 0.271
ENSG00000165915 E032 40.4518086 0.0006124901 9.426234e-01 9.679662e-01 11 47415160 47415287 128 + 1.559 1.560 0.002
ENSG00000165915 E033 230.5718129 0.0013201015 8.832756e-02 1.725715e-01 11 47415288 47415496 209 + 2.257 2.315 0.195
ENSG00000165915 E034 679.2762367 0.0012713942 2.407733e-05 1.466445e-04 11 47415497 47416324 828 + 2.701 2.792 0.301
ENSG00000165915 E035 129.7601572 0.0046733403 5.201231e-02 1.127424e-01 11 47416325 47416496 172 + 1.977 2.079 0.340