ENSG00000165914

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000553972 ENSG00000165914 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC7B protein_coding protein_coding 22.59564 28.89502 23.24791 1.250442 0.3446898 -0.3135985 6.721954 9.404318 6.494117 0.2189322 0.38048080 -0.53350345 0.2908042 0.3267667 0.2790333 -0.04773333 0.365599722 0.000275048 FALSE TRUE
ENST00000555005 ENSG00000165914 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC7B protein_coding nonsense_mediated_decay 22.59564 28.89502 23.24791 1.250442 0.3446898 -0.3135985 4.680749 6.343427 3.323331 0.2852751 0.42068897 -0.93057046 0.2089583 0.2207667 0.1435000 -0.07726667 0.123318623 0.000275048 TRUE TRUE
ENST00000557187 ENSG00000165914 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC7B protein_coding processed_transcript 22.59564 28.89502 23.24791 1.250442 0.3446898 -0.3135985 1.649800 3.324667 1.738002 0.3868313 0.24167163 -0.93183589 0.0686250 0.1143667 0.0747000 -0.03966667 0.153941666 0.000275048   FALSE
MSTRG.10070.2 ENSG00000165914 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC7B protein_coding   22.59564 28.89502 23.24791 1.250442 0.3446898 -0.3135985 5.818300 5.950565 7.429302 0.5711864 0.09031851 0.31971806 0.2624250 0.2052000 0.3196333 0.11443333 0.000275048 0.000275048 TRUE TRUE
MSTRG.10070.6 ENSG00000165914 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC7B protein_coding   22.59564 28.89502 23.24791 1.250442 0.3446898 -0.3135985 2.804530 3.343789 3.243666 0.5408666 0.21756570 -0.04372567 0.1265667 0.1148333 0.1394333 0.02460000 0.573370108 0.000275048 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000165914 E001 9.2542710 0.0202655202 9.879754e-02 1.886436e-01 14 90524564 90525444 881 - 0.866 1.079 0.791
ENSG00000165914 E002 4.3813729 0.0038748812 8.150879e-01 8.828511e-01 14 90525445 90525647 203 - 0.708 0.743 0.141
ENSG00000165914 E003 4.2981929 0.0667063335 6.570454e-01 7.664875e-01 14 90525648 90530473 4826 - 0.769 0.691 -0.316
ENSG00000165914 E004 3.0956225 0.0077783860 9.389528e-01 9.656704e-01 14 90530474 90530571 98 - 0.601 0.614 0.059
ENSG00000165914 E005 14.8393514 0.0015252178 4.153516e-02 9.387967e-02 14 90530572 90540587 10016 - 1.059 1.249 0.677
ENSG00000165914 E006 38.3509842 0.0033709964 2.800009e-06 2.110249e-05 14 90540588 90540641 54 - 1.363 1.679 1.084
ENSG00000165914 E007 347.4120215 0.0014267069 3.277107e-12 7.392863e-11 14 90540642 90541170 529 - 2.411 2.592 0.603
ENSG00000165914 E008 83.1605153 0.0015044315 2.608024e-01 3.983893e-01 14 90541171 90541185 15 - 1.881 1.932 0.169
ENSG00000165914 E009 110.5527384 0.0010319456 1.556428e-01 2.692741e-01 14 90541186 90541260 75 - 2.002 2.056 0.182
ENSG00000165914 E010 93.8308306 0.0002939513 4.754063e-02 1.048027e-01 14 90541261 90541317 57 - 1.916 1.992 0.255
ENSG00000165914 E011 193.1227928 0.0011649381 1.097834e-02 3.111118e-02 14 90541318 90541589 272 - 2.228 2.307 0.263
ENSG00000165914 E012 102.0656523 0.0002947347 1.756370e-01 2.955159e-01 14 90578106 90578184 79 - 1.970 2.020 0.168
ENSG00000165914 E013 128.2837472 0.0041628384 1.461356e-01 2.564324e-01 14 90578185 90578308 124 - 2.058 2.126 0.228
ENSG00000165914 E014 0.1515154 0.0424021539 3.764382e-01   14 90585616 90585799 184 - 0.138 0.000 -12.664
ENSG00000165914 E015 140.0270242 0.0002461948 6.520167e-03 1.997487e-02 14 90593486 90593626 141 - 2.083 2.168 0.286
ENSG00000165914 E016 0.2965864 0.2203432684 3.477540e-01   14 90593627 90593931 305 - 0.000 0.191 11.859
ENSG00000165914 E017 0.1482932 0.0413086356 6.248151e-01   14 90602006 90602200 195 - 0.000 0.108 11.364
ENSG00000165914 E018 0.0000000       14 90603253 90603303 51 -      
ENSG00000165914 E019 0.0000000       14 90605597 90605758 162 -      
ENSG00000165914 E020 106.1600917 0.0002840157 1.805367e-01 3.018563e-01 14 90610742 90610793 52 - 1.985 2.034 0.164
ENSG00000165914 E021 96.7586345 0.0004324710 4.705718e-01 6.097995e-01 14 90610794 90610839 46 - 1.958 1.986 0.096
ENSG00000165914 E022 124.7959447 0.0013690707 8.775655e-01 9.253400e-01 14 90617929 90618045 117 - 2.079 2.086 0.025
ENSG00000165914 E023 143.0985344 0.0006980273 6.811819e-01 7.849341e-01 14 90644048 90644208 161 - 2.150 2.138 -0.037
ENSG00000165914 E024 0.0000000       14 90644817 90644944 128 -      
ENSG00000165914 E025 0.2965864 0.2203432684 3.477540e-01   14 90646948 90646950 3 - 0.000 0.191 11.859
ENSG00000165914 E026 95.0800079 0.0003277115 8.519446e-01 9.082221e-01 14 90646951 90647023 73 - 1.972 1.966 -0.017
ENSG00000165914 E027 77.1813905 0.0004015007 5.540135e-01 6.830640e-01 14 90652841 90652898 58 - 1.894 1.872 -0.075
ENSG00000165914 E028 119.7366402 0.0002923608 6.830814e-01 7.863958e-01 14 90654993 90655110 118 - 2.074 2.063 -0.039
ENSG00000165914 E029 118.4093139 0.0003506888 3.188826e-01 4.618813e-01 14 90657174 90657278 105 - 2.081 2.050 -0.105
ENSG00000165914 E030 1.6511999 0.0094224319 9.242667e-03 2.689288e-02 14 90657279 90657447 169 - 0.640 0.195 -2.569
ENSG00000165914 E031 0.0000000       14 90657849 90658018 170 -      
ENSG00000165914 E032 105.4569787 0.0003268398 9.927318e-01 9.995459e-01 14 90658304 90658387 84 - 2.014 2.017 0.007
ENSG00000165914 E033 134.1669325 0.0003509946 4.794188e-01 6.177988e-01 14 90676523 90676660 138 - 2.130 2.109 -0.068
ENSG00000165914 E034 0.1482932 0.0413086356 6.248151e-01   14 90677824 90677845 22 - 0.000 0.108 11.364
ENSG00000165914 E035 97.5218363 0.0002897725 5.348909e-01 6.668661e-01 14 90680472 90680535 64 - 1.994 1.973 -0.069
ENSG00000165914 E036 120.5368642 0.0002912912 8.826769e-03 2.584871e-02 14 90689540 90689635 96 - 2.122 2.040 -0.277
ENSG00000165914 E037 105.8108262 0.0009663103 3.117479e-05 1.847739e-04 14 90689636 90689712 77 - 2.104 1.954 -0.501
ENSG00000165914 E038 106.9390648 0.0041182441 3.486874e-03 1.168730e-02 14 90695500 90695578 79 - 2.097 1.967 -0.435
ENSG00000165914 E039 0.2924217 0.0290785164 1.358286e-01   14 90699158 90699223 66 - 0.242 0.000 -13.697
ENSG00000165914 E040 99.9620926 0.0016798773 5.202713e-04 2.235667e-03 14 90730075 90730196 122 - 2.069 1.934 -0.454
ENSG00000165914 E041 81.4769816 0.0005258172 1.619715e-04 8.004649e-04 14 90744792 90744917 126 - 1.987 1.839 -0.497
ENSG00000165914 E042 44.7420750 0.0005199736 3.044414e-02 7.283273e-02 14 90744918 90744922 5 - 1.714 1.603 -0.378
ENSG00000165914 E043 20.8727749 0.0009074800 1.108984e-02 3.138255e-02 14 90772650 90772942 293 - 1.192 1.395 0.708
ENSG00000165914 E044 117.3139055 0.0004096513 3.868330e-03 1.277265e-02 14 90780738 90780902 165 - 2.114 2.019 -0.317
ENSG00000165914 E045 41.7678972 0.0007041106 8.401617e-02 1.658274e-01 14 90780903 90780906 4 - 1.668 1.575 -0.317
ENSG00000165914 E046 96.4307177 0.0050125633 1.898436e-04 9.205348e-04 14 90786174 90786328 155 - 2.074 1.895 -0.603
ENSG00000165914 E047 57.3621471 0.0074275296 3.819144e-07 3.456882e-06 14 90816175 90816479 305 - 1.914 1.603 -1.052