ENSG00000165905

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000325468 ENSG00000165905 HEK293_OSMI2_2hA HEK293_TMG_2hB LARGE2 protein_coding protein_coding 7.012632 9.934854 6.390279 0.5559602 0.419326 -0.6358154 0.9466847 2.3427370 0.73198100 0.42728027 0.48685077 -1.6648859 0.14139583 0.23300000 0.12260000 -0.11040000 0.543236527 0.004212431 FALSE TRUE
ENST00000401752 ENSG00000165905 HEK293_OSMI2_2hA HEK293_TMG_2hB LARGE2 protein_coding protein_coding 7.012632 9.934854 6.390279 0.5559602 0.419326 -0.6358154 0.9946718 0.4888771 1.40212795 0.48887713 0.70110001 1.5011144 0.13164167 0.04810000 0.20840000 0.16030000 0.465506366 0.004212431 FALSE TRUE
ENST00000414027 ENSG00000165905 HEK293_OSMI2_2hA HEK293_TMG_2hB LARGE2 protein_coding retained_intron 7.012632 9.934854 6.390279 0.5559602 0.419326 -0.6358154 1.6283928 2.1156149 1.56928741 0.45798558 0.20056101 -0.4286065 0.24585833 0.21166667 0.24436667 0.03270000 0.780502094 0.004212431 FALSE FALSE
ENST00000525609 ENSG00000165905 HEK293_OSMI2_2hA HEK293_TMG_2hB LARGE2 protein_coding retained_intron 7.012632 9.934854 6.390279 0.5559602 0.419326 -0.6358154 0.4117877 0.3213464 0.61407697 0.02294533 0.09528401 0.9133839 0.06492083 0.03246667 0.09736667 0.06490000 0.004212431 0.004212431 FALSE FALSE
ENST00000528236 ENSG00000165905 HEK293_OSMI2_2hA HEK293_TMG_2hB LARGE2 protein_coding retained_intron 7.012632 9.934854 6.390279 0.5559602 0.419326 -0.6358154 0.7665951 0.6303882 0.48869113 0.08138863 0.11117894 -0.3608003 0.12651667 0.06293333 0.07580000 0.01286667 0.808958482 0.004212431 TRUE TRUE
ENST00000529052 ENSG00000165905 HEK293_OSMI2_2hA HEK293_TMG_2hB LARGE2 protein_coding protein_coding 7.012632 9.934854 6.390279 0.5559602 0.419326 -0.6358154 0.2641954 0.7272546 0.08357484 0.37075677 0.08357484 -2.9779704 0.03396667 0.07556667 0.01310000 -0.06246667 0.558630637 0.004212431 FALSE TRUE
ENST00000531847 ENSG00000165905 HEK293_OSMI2_2hA HEK293_TMG_2hB LARGE2 protein_coding protein_coding 7.012632 9.934854 6.390279 0.5559602 0.419326 -0.6358154 0.9878812 1.9618845 1.05056353 0.06694249 0.26885944 -0.8947440 0.12044167 0.19896667 0.16030000 -0.03866667 0.676426451 0.004212431 FALSE FALSE
MSTRG.5441.5 ENSG00000165905 HEK293_OSMI2_2hA HEK293_TMG_2hB LARGE2 protein_coding   7.012632 9.934854 6.390279 0.5559602 0.419326 -0.6358154 0.6915683 1.1680847 0.38277636 0.28178646 0.38277636 -1.5846633 0.09291250 0.11713333 0.06750000 -0.04963333 0.284458531 0.004212431 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000165905 E001 0.000000       11 45921621 45921644 24 +      
ENSG00000165905 E002 0.000000       11 45921645 45921693 49 +      
ENSG00000165905 E003 4.130492 0.2211271110 0.268375057 0.40682522 11 45922656 45922728 73 + 0.832 0.591 -0.995
ENSG00000165905 E004 2.832660 0.0953880497 0.845703493 0.90405140 11 45922778 45922820 43 + 0.566 0.534 -0.150
ENSG00000165905 E005 8.276877 0.1346460567 0.304877880 0.44690653 11 45922821 45922964 144 + 1.051 0.866 -0.690
ENSG00000165905 E006 6.754342 0.0231512571 0.045933257 0.10191509 11 45922965 45923057 93 + 1.016 0.744 -1.045
ENSG00000165905 E007 13.435816 0.0028495102 0.257083512 0.39412579 11 45923058 45923167 110 + 1.185 1.076 -0.390
ENSG00000165905 E008 20.266642 0.0009877958 0.832918028 0.89532473 11 45923473 45923555 83 + 1.296 1.279 -0.061
ENSG00000165905 E009 2.171395 0.1235501396 0.047346451 0.10444634 11 45924150 45924153 4 + 0.701 0.295 -2.050
ENSG00000165905 E010 36.099793 0.0010333736 0.545733444 0.67601863 11 45924154 45924277 124 + 1.497 1.534 0.127
ENSG00000165905 E011 3.424665 0.0047200091 0.101677595 0.19304986 11 45924454 45924505 52 + 0.772 0.527 -1.055
ENSG00000165905 E012 47.458591 0.0005483808 0.500636054 0.63687457 11 45924506 45924616 111 + 1.664 1.628 -0.123
ENSG00000165905 E013 43.372264 0.0006060128 0.293673012 0.43472669 11 45924617 45924677 61 + 1.643 1.585 -0.197
ENSG00000165905 E014 18.695623 0.0014668040 0.251591519 0.38784987 11 45924678 45924784 107 + 1.316 1.221 -0.331
ENSG00000165905 E015 56.498537 0.0004592960 0.795236834 0.86922665 11 45924785 45924889 105 + 1.727 1.714 -0.045
ENSG00000165905 E016 35.447933 0.0053533491 0.852076325 0.90830639 11 45926039 45926151 113 + 1.532 1.519 -0.045
ENSG00000165905 E017 5.889562 0.0028224328 0.126030564 0.22861737 11 45926152 45926221 70 + 0.935 0.740 -0.757
ENSG00000165905 E018 50.773002 0.0004791895 0.934601968 0.96280296 11 45926222 45926347 126 + 1.673 1.676 0.011
ENSG00000165905 E019 0.147249 0.0427416873 0.262472603   11 45926363 45926441 79 + 0.161 0.000 -9.069
ENSG00000165905 E020 24.369920 0.0008307316 0.737155416 0.82740435 11 45926442 45926450 9 + 1.343 1.367 0.084
ENSG00000165905 E021 52.196274 0.0005256624 0.670669240 0.77705822 11 45926451 45926597 147 + 1.701 1.678 -0.076
ENSG00000165905 E022 55.719373 0.0004583546 0.564164566 0.69151123 11 45926711 45926871 161 + 1.734 1.705 -0.097
ENSG00000165905 E023 45.887616 0.0006580618 0.446034765 0.58757639 11 45927315 45927444 130 + 1.601 1.642 0.140
ENSG00000165905 E024 52.898896 0.0212929224 0.906180415 0.94435395 11 45927445 45927593 149 + 1.685 1.702 0.058
ENSG00000165905 E025 3.828957 0.0043118810 0.870036070 0.92039246 11 45927749 45927919 171 + 0.661 0.635 -0.108
ENSG00000165905 E026 41.324325 0.0128197987 0.109942976 0.20546267 11 45927920 45928035 116 + 1.497 1.627 0.444
ENSG00000165905 E027 27.368489 0.0008021709 0.059500778 0.12576581 11 45928036 45928069 34 + 1.316 1.451 0.469
ENSG00000165905 E028 42.781930 0.0005886610 0.860970713 0.91433555 11 45928177 45928372 196 + 1.591 1.601 0.032
ENSG00000165905 E029 72.144241 0.0003689218 0.009486414 0.02750283 11 45928630 45929096 467 + 1.741 1.855 0.384