ENSG00000165868

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369209 ENSG00000165868 HEK293_OSMI2_2hA HEK293_TMG_2hB HSPA12A protein_coding protein_coding 8.648621 9.898035 7.741336 0.392773 0.1471347 -0.3541541 2.6545631 3.30198156 2.7736578 0.52029318 0.39330801 -0.2507128 0.31646250 0.33213333 0.35993333 0.027800000 9.198118e-01 4.06793e-06 FALSE TRUE
ENST00000453491 ENSG00000165868 HEK293_OSMI2_2hA HEK293_TMG_2hB HSPA12A protein_coding processed_transcript 8.648621 9.898035 7.741336 0.392773 0.1471347 -0.3541541 0.4527911 0.40200322 0.2404413 0.03246614 0.02181181 -0.7181829 0.05173750 0.04056667 0.03110000 -0.009466667 6.778608e-01 4.06793e-06   FALSE
ENST00000481291 ENSG00000165868 HEK293_OSMI2_2hA HEK293_TMG_2hB HSPA12A protein_coding retained_intron 8.648621 9.898035 7.741336 0.392773 0.1471347 -0.3541541 0.4925932 0.24813406 0.5895342 0.01878025 0.04101538 1.2157215 0.05970000 0.02516667 0.07640000 0.051233333 1.648776e-03 4.06793e-06 FALSE TRUE
ENST00000674291 ENSG00000165868 HEK293_OSMI2_2hA HEK293_TMG_2hB HSPA12A protein_coding retained_intron 8.648621 9.898035 7.741336 0.392773 0.1471347 -0.3541541 1.0058127 1.74563314 0.1848441 0.41982702 0.10092539 -3.1715990 0.10990833 0.17813333 0.02396667 -0.154166667 4.092364e-03 4.06793e-06 FALSE TRUE
ENST00000674389 ENSG00000165868 HEK293_OSMI2_2hA HEK293_TMG_2hB HSPA12A protein_coding retained_intron 8.648621 9.898035 7.741336 0.392773 0.1471347 -0.3541541 0.6400230 0.37874306 0.7213026 0.04164395 0.07708804 0.9116515 0.07597083 0.03820000 0.09290000 0.054700000 6.862615e-03 4.06793e-06 FALSE TRUE
MSTRG.4696.27 ENSG00000165868 HEK293_OSMI2_2hA HEK293_TMG_2hB HSPA12A protein_coding   8.648621 9.898035 7.741336 0.392773 0.1471347 -0.3541541 0.9784604 2.17656623 0.3798139 0.09105580 0.11558294 -2.4878096 0.10589583 0.21986667 0.04853333 -0.171333333 4.067930e-06 4.06793e-06 FALSE TRUE
MSTRG.4696.3 ENSG00000165868 HEK293_OSMI2_2hA HEK293_TMG_2hB HSPA12A protein_coding   8.648621 9.898035 7.741336 0.392773 0.1471347 -0.3541541 0.3761305 0.15222444 0.5422751 0.03336528 0.08593814 1.7673960 0.04529583 0.01520000 0.06990000 0.054700000 4.371819e-04 4.06793e-06 FALSE TRUE
MSTRG.4696.4 ENSG00000165868 HEK293_OSMI2_2hA HEK293_TMG_2hB HSPA12A protein_coding   8.648621 9.898035 7.741336 0.392773 0.1471347 -0.3541541 0.3732756 0.03993683 0.7342691 0.03993683 0.40770934 3.8976481 0.04444583 0.00410000 0.09363333 0.089533333 3.691697e-01 4.06793e-06 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000165868 E001 0.4470576 0.0213660431 5.225516e-01 6.563445e-01 10 116671192 116671196 5 - 0.213 0.125 -0.923
ENSG00000165868 E002 6.8072554 0.0350932091 1.095735e-02 3.106105e-02 10 116671197 116671210 14 - 0.620 1.052 1.696
ENSG00000165868 E003 715.3587438 0.0058999886 1.180151e-04 6.047335e-04 10 116671211 116675418 4208 - 2.775 2.914 0.461
ENSG00000165868 E004 33.4707799 0.0006363775 1.265097e-01 2.292983e-01 10 116676399 116676502 104 - 1.554 1.520 -0.118
ENSG00000165868 E005 5.1711640 0.0038803696 5.705000e-01 6.969679e-01 10 116676503 116678334 1832 - 0.805 0.779 -0.102
ENSG00000165868 E006 45.7393029 0.0006000707 7.816753e-03 2.332027e-02 10 116679503 116679761 259 - 1.708 1.628 -0.271
ENSG00000165868 E007 0.7458221 0.0185469866 1.467194e-01 2.572210e-01 10 116679762 116680079 318 - 0.355 0.125 -1.923
ENSG00000165868 E008 33.3450606 0.0006045037 4.072338e-04 1.802510e-03 10 116681152 116681256 105 - 1.608 1.454 -0.529
ENSG00000165868 E009 35.8456590 0.0006674332 2.335014e-03 8.259792e-03 10 116681791 116681877 87 - 1.622 1.502 -0.408
ENSG00000165868 E010 2.0198174 0.0105719670 9.009951e-01 9.408538e-01 10 116681878 116682024 147 - 0.462 0.523 0.298
ENSG00000165868 E011 2.7657241 0.0056022801 4.005624e-01 5.442473e-01 10 116683076 116683455 380 - 0.462 0.638 0.817
ENSG00000165868 E012 4.1170347 0.0077288243 2.606740e-03 9.084604e-03 10 116683456 116683790 335 - 0.355 0.867 2.329
ENSG00000165868 E013 21.4128323 0.0037592204 6.288155e-01 7.442985e-01 10 116683791 116683812 22 - 1.334 1.351 0.060
ENSG00000165868 E014 22.7279543 0.0010322413 4.840199e-01 6.220397e-01 10 116683813 116683831 19 - 1.365 1.370 0.016
ENSG00000165868 E015 41.8699192 0.0005777033 2.563424e-02 6.319231e-02 10 116683832 116683958 127 - 1.659 1.596 -0.215
ENSG00000165868 E016 16.6436663 0.0012277117 2.502046e-02 6.191370e-02 10 116683959 116683962 4 - 1.308 1.177 -0.459
ENSG00000165868 E017 39.2137009 0.0018998891 1.975364e-02 5.096637e-02 10 116692351 116692467 117 - 1.638 1.559 -0.270
ENSG00000165868 E018 35.3508308 0.0025273364 4.111057e-03 1.345404e-02 10 116692468 116694207 1740 - 1.618 1.498 -0.412
ENSG00000165868 E019 9.8215089 0.0017198572 8.131257e-04 3.305954e-03 10 116697855 116698634 780 - 1.165 0.867 -1.099
ENSG00000165868 E020 36.1718743 0.0017776719 1.786980e-04 8.722960e-04 10 116698635 116698739 105 - 1.647 1.479 -0.575
ENSG00000165868 E021 25.1611039 0.0257006118 3.497425e-02 8.160500e-02 10 116700943 116700953 11 - 1.493 1.333 -0.556
ENSG00000165868 E022 45.9999959 0.0005694063 1.589482e-04 7.870838e-04 10 116700954 116701129 176 - 1.737 1.600 -0.464
ENSG00000165868 E023 12.5870090 0.0049978631 2.985973e-09 4.052175e-08 10 116703744 116703968 225 - 0.620 1.343 2.732
ENSG00000165868 E024 51.4550207 0.0014292427 4.072211e-01 5.508086e-01 10 116705151 116705278 128 - 1.711 1.726 0.052
ENSG00000165868 E025 0.0000000       10 116705279 116705376 98 -      
ENSG00000165868 E026 36.7635725 0.0115080304 6.142711e-01 7.327940e-01 10 116707200 116707285 86 - 1.562 1.581 0.063
ENSG00000165868 E027 0.5169874 0.0203494158 6.128781e-01 7.317227e-01 10 116707286 116707378 93 - 0.119 0.222 1.079
ENSG00000165868 E028 0.0000000       10 116708041 116708246 206 -      
ENSG00000165868 E029 3.3352567 0.0047978579 3.234881e-02 7.653114e-02 10 116727227 116727380 154 - 0.760 0.478 -1.243
ENSG00000165868 E030 0.0000000       10 116742006 116742078 73 -      
ENSG00000165868 E031 23.7362745 0.0335163963 5.487823e-01 6.786105e-01 10 116742430 116742596 167 - 1.395 1.382 -0.044
ENSG00000165868 E032 8.2887679 0.0021218226 3.155828e-01 4.583472e-01 10 116826791 116828736 1946 - 0.865 1.030 0.616
ENSG00000165868 E033 3.5802549 0.0192090156 6.579673e-02 1.363665e-01 10 116828764 116829075 312 - 0.462 0.801 1.485
ENSG00000165868 E034 37.9238165 0.0005402547 9.853692e-03 2.840492e-02 10 116829076 116833066 3991 - 1.470 1.673 0.695
ENSG00000165868 E035 1.6241299 0.1896689892 3.242296e-01 4.676056e-01 10 116833067 116833091 25 - 0.508 0.305 -1.123
ENSG00000165868 E036 7.6861234 0.0272937881 9.924316e-01 9.993541e-01 10 116833092 116833373 282 - 0.919 0.968 0.186
ENSG00000165868 E037 2.1799423 0.0066234011 2.059684e-02 5.274124e-02 10 116833374 116834934 1561 - 0.652 0.302 -1.796
ENSG00000165868 E038 7.1962138 0.0025033907 1.255431e-01 2.279251e-01 10 116834935 116835022 88 - 0.783 1.015 0.885
ENSG00000165868 E039 3.0310033 0.0072388650 6.164519e-01 7.345028e-01 10 116835198 116835257 60 - 0.548 0.670 0.536
ENSG00000165868 E040 1.0266130 0.0124717945 1.109747e-01 2.069743e-01 10 116847595 116848223 629 - 0.119 0.427 2.400
ENSG00000165868 E041 4.9973608 0.0372667863 2.597596e-01 3.972158e-01 10 116849566 116849741 176 - 0.652 0.882 0.927
ENSG00000165868 E042 0.2998086 0.0291466959 9.534720e-01   10 116850091 116850251 161 - 0.120 0.125 0.076