ENSG00000165806

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369318 ENSG00000165806 HEK293_OSMI2_2hA HEK293_TMG_2hB CASP7 protein_coding protein_coding 9.710141 8.570624 14.54647 1.388787 0.3288069 0.762506 4.499573 4.5936975 6.0530930 0.7244662 0.06281151 0.39726091 0.48768750 0.53816667 0.41646667 -0.12170000 0.067094602 0.006932184 FALSE TRUE
ENST00000621345 ENSG00000165806 HEK293_OSMI2_2hA HEK293_TMG_2hB CASP7 protein_coding protein_coding 9.710141 8.570624 14.54647 1.388787 0.3288069 0.762506 4.175678 2.7586532 6.7388165 0.5268877 0.41688026 1.28545016 0.40323750 0.31983333 0.46243333 0.14260000 0.006932184 0.006932184 FALSE TRUE
MSTRG.4660.7 ENSG00000165806 HEK293_OSMI2_2hA HEK293_TMG_2hB CASP7 protein_coding   9.710141 8.570624 14.54647 1.388787 0.3288069 0.762506 0.543673 0.7207112 0.7563265 0.3756112 0.32850568 0.06865798 0.05552917 0.07903333 0.05306667 -0.02596667 0.985996193 0.006932184 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000165806 E001 1.1834165 0.0107362032 9.959806e-02 1.898638e-01 10 113679162 113679182 21 + 0.439 0.153 -2.047
ENSG00000165806 E002 6.3388643 0.0077088633 1.501378e-01 2.618617e-01 10 113679183 113679203 21 + 0.916 0.753 -0.635
ENSG00000165806 E003 26.1223879 0.0007277139 1.241785e-02 3.454160e-02 10 113679204 113679349 146 + 1.484 1.346 -0.478
ENSG00000165806 E004 0.4815130 0.0208139377 3.404728e-01 4.844168e-01 10 113679669 113679859 191 + 0.097 0.266 1.760
ENSG00000165806 E005 2.9717713 0.0642250222 8.404426e-01 9.004090e-01 10 113679860 113679911 52 + 0.575 0.639 0.283
ENSG00000165806 E006 11.1893458 0.0015450274 7.808176e-01 8.591764e-01 10 113679912 113679939 28 + 1.088 1.094 0.023
ENSG00000165806 E007 15.9146006 0.0011572079 5.613369e-01 6.891734e-01 10 113679940 113679978 39 + 1.237 1.222 -0.052
ENSG00000165806 E008 0.9556140 0.2598445791 4.120600e-01 5.556202e-01 10 113691964 113691971 8 + 0.352 0.156 -1.532
ENSG00000165806 E009 1.7221618 0.2046930524 3.433024e-01 4.873373e-01 10 113691972 113691996 25 + 0.511 0.270 -1.381
ENSG00000165806 E010 2.5682189 0.0372966505 2.308630e-02 5.792657e-02 10 113691997 113692070 74 + 0.676 0.267 -2.142
ENSG00000165806 E011 72.8311827 0.0003838229 1.588385e-02 4.247748e-02 10 113697494 113697603 110 + 1.895 1.832 -0.212
ENSG00000165806 E012 0.2965864 0.0371183049 1.088047e-01   10 113709261 113709344 84 + 0.000 0.266 11.495
ENSG00000165806 E013 0.3697384 0.0248611156 1.038536e-01 1.963775e-01 10 113709345 113709446 102 + 0.000 0.267 11.625
ENSG00000165806 E014 0.0000000       10 113719210 113719643 434 +      
ENSG00000165806 E015 0.0000000       10 113720998 113721000 3 +      
ENSG00000165806 E016 0.6277178 0.0276275689 5.754039e-01 7.010106e-01 10 113721001 113721031 31 + 0.243 0.153 -0.823
ENSG00000165806 E017 75.3570292 0.0003637595 1.632790e-02 4.345093e-02 10 113721032 113721168 137 + 1.908 1.848 -0.204
ENSG00000165806 E018 69.8821349 0.0004119650 1.538622e-02 4.136677e-02 10 113721651 113721779 129 + 1.876 1.810 -0.225
ENSG00000165806 E019 55.0542662 0.0022760710 5.834865e-02 1.237958e-01 10 113725362 113725429 68 + 1.776 1.713 -0.213
ENSG00000165806 E020 65.5692434 0.0006052157 1.614053e-02 4.304239e-02 10 113725430 113725537 108 + 1.851 1.780 -0.239
ENSG00000165806 E021 2.7250529 0.0372253351 1.809197e-01 3.023721e-01 10 113725817 113725890 74 + 0.439 0.684 1.131
ENSG00000165806 E022 90.9484479 0.0002990522 1.650147e-02 4.384693e-02 10 113726305 113726434 130 + 1.984 1.933 -0.173
ENSG00000165806 E023 506.6663680 0.0020558082 8.583170e-10 1.287557e-08 10 113729311 113730907 1597 + 2.646 2.772 0.419