ENSG00000165802

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265663 ENSG00000165802 HEK293_OSMI2_2hA HEK293_TMG_2hB NSMF protein_coding protein_coding 91.18757 138.5925 58.92692 10.75464 0.9258502 -1.23371 54.442511 97.865792 24.420988 8.0842555 0.7986090 -2.00223986 0.55464167 0.70556667 0.41436667 -0.29120000 1.248507e-36 2.175785e-64 FALSE TRUE
ENST00000371468 ENSG00000165802 HEK293_OSMI2_2hA HEK293_TMG_2hB NSMF protein_coding retained_intron 91.18757 138.5925 58.92692 10.75464 0.9258502 -1.23371 4.582471 3.389460 4.647325 0.3024506 0.2823428 0.45419590 0.05789583 0.02443333 0.07880000 0.05436667 1.937950e-19 2.175785e-64 FALSE TRUE
ENST00000371472 ENSG00000165802 HEK293_OSMI2_2hA HEK293_TMG_2hB NSMF protein_coding protein_coding 91.18757 138.5925 58.92692 10.75464 0.9258502 -1.23371 4.856928 0.000000 9.034940 0.0000000 0.8245057 9.82096717 0.08018333 0.00000000 0.15323333 0.15323333 2.175785e-64 2.175785e-64 FALSE TRUE
ENST00000371474 ENSG00000165802 HEK293_OSMI2_2hA HEK293_TMG_2hB NSMF protein_coding protein_coding 91.18757 138.5925 58.92692 10.75464 0.9258502 -1.23371 12.175979 22.432211 5.948221 0.6776450 0.2892857 -1.91326130 0.12411250 0.16480000 0.10096667 -0.06383333 2.837797e-02 2.175785e-64 FALSE TRUE
MSTRG.33709.10 ENSG00000165802 HEK293_OSMI2_2hA HEK293_TMG_2hB NSMF protein_coding   91.18757 138.5925 58.92692 10.75464 0.9258502 -1.23371 4.376170 3.617876 3.665210 2.3516023 0.5032780 0.01870178 0.05357917 0.02433333 0.06233333 0.03800000 3.498300e-01 2.175785e-64 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000165802 E001 6.078755 2.711542e-03 9.721308e-04 3.863381e-03 9 137447570 137447572 3 - 1.064 0.645 -1.632
ENSG00000165802 E002 194.535527 6.026720e-03 2.124844e-01 3.414758e-01 9 137447573 137448044 472 - 2.142 2.209 0.223
ENSG00000165802 E003 88.190717 2.802254e-03 4.260805e-02 9.583018e-02 9 137448045 137448224 180 - 1.764 1.876 0.377
ENSG00000165802 E004 62.097398 3.384848e-03 3.203422e-02 7.592342e-02 9 137448225 137448231 7 - 1.594 1.732 0.470
ENSG00000165802 E005 95.123613 1.473366e-02 5.465022e-02 1.173912e-01 9 137448232 137448286 55 - 1.764 1.917 0.515
ENSG00000165802 E006 1166.950515 2.347038e-03 7.863774e-16 3.009633e-14 9 137448287 137448706 420 - 2.786 3.008 0.740
ENSG00000165802 E007 1116.116302 2.591211e-03 6.577762e-07 5.682082e-06 9 137448707 137449041 335 - 2.833 2.978 0.481
ENSG00000165802 E008 1496.249135 2.913618e-04 1.936918e-08 2.265362e-07 9 137449042 137449390 349 - 3.011 3.091 0.267
ENSG00000165802 E009 1262.412902 9.269421e-05 9.065713e-03 2.644340e-02 9 137449391 137449491 101 - 2.974 3.009 0.116
ENSG00000165802 E010 728.795623 1.077822e-04 1.342429e-01 2.400551e-01 9 137449599 137449606 8 - 2.743 2.769 0.087
ENSG00000165802 E011 833.061367 8.647040e-05 5.114979e-02 1.112114e-01 9 137449607 137449636 30 - 2.796 2.827 0.105
ENSG00000165802 E012 876.982107 3.573595e-04 8.708237e-01 9.209891e-01 9 137449637 137449674 38 - 2.846 2.846 0.000
ENSG00000165802 E013 725.535493 1.013738e-04 6.185975e-01 7.361953e-01 9 137449923 137449934 12 - 2.766 2.760 -0.022
ENSG00000165802 E014 1133.461882 1.204859e-04 6.793200e-02 1.399362e-01 9 137449935 137450025 91 - 2.972 2.950 -0.073
ENSG00000165802 E015 4.612550 4.369471e-03 3.355896e-07 3.073519e-06 9 137450026 137450100 75 - 1.106 0.418 -2.861
ENSG00000165802 E016 1091.367494 1.723320e-04 1.193828e-01 2.190630e-01 9 137450176 137450255 80 - 2.954 2.934 -0.064
ENSG00000165802 E017 1073.724556 1.766761e-03 5.328024e-02 1.149869e-01 9 137452365 137452435 71 - 2.966 2.926 -0.131
ENSG00000165802 E018 13.459108 1.261544e-03 3.523469e-11 6.706543e-10 9 137452465 137452552 88 - 1.466 0.863 -2.165
ENSG00000165802 E019 856.334743 1.183082e-03 1.949718e-04 9.424230e-04 9 137452553 137452586 34 - 2.894 2.820 -0.249
ENSG00000165802 E020 34.248116 5.758906e-04 5.798918e-26 6.913705e-24 9 137452587 137452735 149 - 1.862 1.231 -2.165
ENSG00000165802 E021 1069.073858 8.163886e-05 1.662668e-04 8.191704e-04 9 137452736 137452819 84 - 2.967 2.919 -0.159
ENSG00000165802 E022 45.806210 1.885181e-03 2.491435e-28 3.633524e-26 9 137452820 137453055 236 - 1.973 1.362 -2.080
ENSG00000165802 E023 1080.406205 3.353100e-04 1.817180e-01 3.033923e-01 9 137453056 137453180 125 - 2.949 2.932 -0.057
ENSG00000165802 E024 36.974267 1.818140e-02 7.074875e-10 1.080478e-08 9 137453181 137453730 550 - 1.837 1.310 -1.803
ENSG00000165802 E025 729.498611 1.022214e-04 6.676415e-03 2.038235e-02 9 137453731 137453820 90 - 2.726 2.772 0.155
ENSG00000165802 E026 609.431994 3.579730e-04 8.550000e-03 2.516580e-02 9 137454391 137454443 53 - 2.641 2.696 0.182
ENSG00000165802 E027 32.600866 6.139638e-04 2.052788e-11 4.060290e-10 9 137454444 137454537 94 - 1.727 1.303 -1.457
ENSG00000165802 E028 78.526250 1.391104e-03 2.846679e-26 3.468133e-24 9 137454538 137454977 440 - 2.125 1.657 -1.578
ENSG00000165802 E029 514.643873 4.420377e-03 8.569876e-01 9.116284e-01 9 137455239 137455307 69 - 2.615 2.615 0.001
ENSG00000165802 E030 21.538326 4.248052e-02 1.076683e-02 3.060794e-02 9 137455629 137455634 6 - 1.493 1.169 -1.130
ENSG00000165802 E031 662.437664 2.560610e-03 7.685363e-01 8.504142e-01 9 137456411 137456486 76 - 2.726 2.724 -0.007
ENSG00000165802 E032 1374.664738 4.407865e-03 1.124881e-01 2.091687e-01 9 137457407 137457901 495 - 3.076 3.033 -0.141
ENSG00000165802 E033 346.643037 2.230593e-03 1.726179e-05 1.086407e-04 9 137458488 137458549 62 - 2.542 2.413 -0.433
ENSG00000165802 E034 237.677160 1.261158e-02 1.855669e-05 1.160004e-04 9 137459032 137459338 307 - 2.465 2.219 -0.820