ENSG00000165792

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000339374 ENSG00000165792 HEK293_OSMI2_2hA HEK293_TMG_2hB METTL17 protein_coding protein_coding 103.6111 119.141 94.33453 2.778979 1.51968 -0.3367803 36.845376 51.995931 31.860675 2.9148800 0.8570883 -0.7064466 0.35618750 0.43600000 0.33770000 -0.09830000 4.431164e-03 1.0822e-08 FALSE  
ENST00000382985 ENSG00000165792 HEK293_OSMI2_2hA HEK293_TMG_2hB METTL17 protein_coding protein_coding 103.6111 119.141 94.33453 2.778979 1.51968 -0.3367803 29.695404 39.176784 22.513018 1.8992322 0.3058543 -0.7989671 0.28303750 0.32843333 0.23880000 -0.08963333 1.614849e-05 1.0822e-08 FALSE  
ENST00000553389 ENSG00000165792 HEK293_OSMI2_2hA HEK293_TMG_2hB METTL17 protein_coding retained_intron 103.6111 119.141 94.33453 2.778979 1.51968 -0.3367803 5.483999 4.409998 5.670317 1.0429557 0.5901277 0.3619259 0.05223750 0.03703333 0.06016667 0.02313333 3.310829e-01 1.0822e-08 FALSE  
ENST00000555533 ENSG00000165792 HEK293_OSMI2_2hA HEK293_TMG_2hB METTL17 protein_coding nonsense_mediated_decay 103.6111 119.141 94.33453 2.778979 1.51968 -0.3367803 6.537429 10.138492 2.825087 1.2850450 0.4851570 -1.8398005 0.06166667 0.08563333 0.03010000 -0.05553333 1.535500e-03 1.0822e-08 FALSE  
ENST00000555640 ENSG00000165792 HEK293_OSMI2_2hA HEK293_TMG_2hB METTL17 protein_coding nonsense_mediated_decay 103.6111 119.141 94.33453 2.778979 1.51968 -0.3367803 5.224076 2.081750 6.366304 0.3062551 0.4319991 1.6080098 0.05180000 0.01760000 0.06746667 0.04986667 1.082200e-08 1.0822e-08 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000165792 E001 7.0839609 0.0727699414 9.493523e-01 9.722923e-01 14 20989973 20989979 7 + 0.900 0.887 -0.048
ENSG00000165792 E002 10.4065442 0.0039650090 1.917718e-01 3.159787e-01 14 20989980 20989986 7 + 1.123 0.991 -0.477
ENSG00000165792 E003 39.6558206 0.0005435420 4.621179e-11 8.627006e-10 14 20989987 20989993 7 + 1.786 1.426 -1.227
ENSG00000165792 E004 69.3679757 0.0038264796 3.413493e-04 1.545630e-03 14 20989994 20989995 2 + 1.932 1.750 -0.616
ENSG00000165792 E005 89.8740273 0.0016238194 2.601273e-02 6.396970e-02 14 20989996 20989998 3 + 1.991 1.900 -0.305
ENSG00000165792 E006 99.7241801 0.0006413917 1.483134e-02 4.011069e-02 14 20989999 20990001 3 + 2.034 1.946 -0.293
ENSG00000165792 E007 104.1798128 0.0008232280 9.280397e-03 2.698550e-02 14 20990002 20990002 1 + 2.056 1.963 -0.313
ENSG00000165792 E008 262.6915654 0.0026201740 1.191337e-02 3.332622e-02 14 20990003 20990029 27 + 2.449 2.368 -0.271
ENSG00000165792 E009 259.7642081 0.0019649200 7.609093e-03 2.279587e-02 14 20990030 20990031 2 + 2.444 2.364 -0.266
ENSG00000165792 E010 262.9674289 0.0015759308 2.831430e-03 9.768107e-03 14 20990032 20990035 4 + 2.452 2.368 -0.281
ENSG00000165792 E011 280.8105883 0.0010036510 3.217011e-03 1.090588e-02 14 20990036 20990042 7 + 2.474 2.400 -0.247
ENSG00000165792 E012 294.8812451 0.0009449929 5.243903e-03 1.659476e-02 14 20990043 20990047 5 + 2.491 2.423 -0.226
ENSG00000165792 E013 352.9174636 0.0007564195 4.059515e-03 1.330881e-02 14 20990048 20990077 30 + 2.566 2.503 -0.210
ENSG00000165792 E014 34.3226110 0.0006069826 3.807405e-05 2.206084e-04 14 20990078 20990229 152 + 1.666 1.426 -0.822
ENSG00000165792 E015 361.0463640 0.0001734776 4.827041e-05 2.730327e-04 14 20990230 20990262 33 + 2.584 2.509 -0.251
ENSG00000165792 E016 562.6001259 0.0001857623 6.692246e-03 2.042607e-02 14 20990263 20990383 121 + 2.755 2.715 -0.132
ENSG00000165792 E017 22.9361160 0.0008484218 1.035072e-13 2.936305e-12 14 20990384 20990463 80 + 1.626 1.094 -1.856
ENSG00000165792 E018 563.3507933 0.0011564759 4.984974e-01 6.349555e-01 14 20990464 20990546 83 + 2.738 2.726 -0.039
ENSG00000165792 E019 435.2352965 0.0001817303 2.043022e-01 3.315410e-01 14 20990547 20990568 22 + 2.631 2.612 -0.061
ENSG00000165792 E020 343.5885531 0.0001991167 4.437305e-02 9.906012e-02 14 20990569 20990575 7 + 2.539 2.503 -0.121
ENSG00000165792 E021 412.4310449 0.0013008578 8.184920e-03 2.425365e-02 14 20990576 20990598 23 + 2.634 2.571 -0.208
ENSG00000165792 E022 3.0428375 0.0116193425 3.416132e-05 2.003392e-04 14 20990599 20990732 134 + 0.900 0.250 -3.161
ENSG00000165792 E023 8.0155659 0.0020329767 5.494870e-11 1.012699e-09 14 20991753 20992091 339 + 1.278 0.523 -2.947
ENSG00000165792 E024 73.4257263 0.0104975534 7.161032e-05 3.879650e-04 14 20992092 20992123 32 + 1.996 1.741 -0.859
ENSG00000165792 E025 665.0998716 0.0014885453 2.772597e-01 4.167970e-01 14 20992124 20992205 82 + 2.816 2.794 -0.073
ENSG00000165792 E026 11.7507522 0.0943888057 1.458865e-05 9.332036e-05 14 20992206 20992304 99 + 1.421 0.669 -2.793
ENSG00000165792 E027 646.3940983 0.0003458589 8.272291e-01 8.913793e-01 14 20992541 20992622 82 + 2.789 2.789 0.002
ENSG00000165792 E028 55.1850506 0.0004278009 3.992595e-55 3.361712e-52 14 20992623 20993116 494 + 2.073 1.299 -2.633
ENSG00000165792 E029 639.2901182 0.0001252420 5.693987e-01 6.959636e-01 14 20993118 20993191 74 + 2.776 2.790 0.045
ENSG00000165792 E030 118.0862358 0.0025322549 8.466404e-56 7.323903e-53 14 20993192 20993968 777 + 2.362 1.710 -2.189
ENSG00000165792 E031 721.3747636 0.0001062753 1.780519e-04 8.697020e-04 14 20993969 20994063 95 + 2.799 2.858 0.195
ENSG00000165792 E032 675.3623600 0.0001008982 9.766653e-03 2.818847e-02 14 20994543 20994613 71 + 2.781 2.824 0.143
ENSG00000165792 E033 621.2902007 0.0001466775 4.904482e-03 1.566396e-02 14 20994794 20994847 54 + 2.742 2.791 0.163
ENSG00000165792 E034 677.4452837 0.0001238113 2.108644e-04 1.010377e-03 14 20994848 20994901 54 + 2.771 2.832 0.200
ENSG00000165792 E035 115.6470091 0.0028614952 4.774402e-27 6.190939e-25 14 20994902 20995116 215 + 2.282 1.836 -1.495
ENSG00000165792 E036 72.8160696 0.0078059919 3.227410e-13 8.532279e-12 14 20995117 20995164 48 + 2.076 1.644 -1.456
ENSG00000165792 E037 770.2998201 0.0010752357 5.511434e-03 1.731722e-02 14 20995165 20995233 69 + 2.825 2.886 0.204
ENSG00000165792 E038 522.7586069 0.0028600500 4.797607e-02 1.055963e-01 14 20995901 20995929 29 + 2.653 2.720 0.221
ENSG00000165792 E039 551.3554245 0.0020289824 3.566855e-03 1.191785e-02 14 20995930 20995951 22 + 2.664 2.748 0.279
ENSG00000165792 E040 73.0331870 0.0064612502 1.597352e-19 9.665076e-18 14 20995952 20996208 257 + 2.110 1.598 -1.729
ENSG00000165792 E041 830.4698514 0.0018424041 9.757039e-03 2.816544e-02 14 20996209 20996292 84 + 2.853 2.920 0.222
ENSG00000165792 E042 960.7906380 0.0009825871 2.616178e-07 2.450687e-06 14 20996527 20996711 185 + 2.893 2.995 0.340
ENSG00000165792 E043 265.7328209 0.0002672785 1.737601e-11 3.476432e-10 14 20996712 20996784 73 + 2.288 2.458 0.567
ENSG00000165792 E044 394.8398982 0.0018583078 1.199153e-12 2.905435e-11 14 20996785 20996811 27 + 2.429 2.639 0.701
ENSG00000165792 E045 501.9357615 0.0012496166 1.448918e-15 5.362243e-14 14 20996812 20996884 73 + 2.541 2.740 0.664
ENSG00000165792 E046 285.1215079 0.0003278734 1.722396e-18 9.217591e-17 14 20996885 20997035 151 + 2.282 2.501 0.731
ENSG00000165792 E047 0.2955422 0.0291861016 7.320065e-01   14 20998430 20998473 44 + 0.149 0.100 -0.660