ENSG00000165782

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000250489 ENSG00000165782 HEK293_OSMI2_2hA HEK293_TMG_2hB PIP4P1 protein_coding protein_coding 39.30596 61.56953 25.64256 2.669999 1.012709 -1.263348 8.374479 15.2785326 4.876948 1.78199845 1.0434928 -1.6454444 0.20327917 0.24680000 0.1875667 -0.05923333 5.223904e-01 5.532754e-21 FALSE TRUE
ENST00000398020 ENSG00000165782 HEK293_OSMI2_2hA HEK293_TMG_2hB PIP4P1 protein_coding protein_coding 39.30596 61.56953 25.64256 2.669999 1.012709 -1.263348 24.724301 43.7135068 14.603428 1.12442673 0.7334193 -1.5811145 0.60356667 0.71130000 0.5734333 -0.13786667 1.227975e-01 5.532754e-21 FALSE TRUE
ENST00000554028 ENSG00000165782 HEK293_OSMI2_2hA HEK293_TMG_2hB PIP4P1 protein_coding retained_intron 39.30596 61.56953 25.64256 2.669999 1.012709 -1.263348 2.674325 0.9158714 3.217502 0.04215434 0.4946384 1.8015342 0.08545000 0.01500000 0.1249667 0.10996667 2.819589e-17 5.532754e-21 FALSE FALSE
ENST00000557041 ENSG00000165782 HEK293_OSMI2_2hA HEK293_TMG_2hB PIP4P1 protein_coding retained_intron 39.30596 61.56953 25.64256 2.669999 1.012709 -1.263348 2.503839 1.4549044 2.618385 0.10580490 0.1621434 0.8433703 0.07654583 0.02356667 0.1020000 0.07843333 5.532754e-21 5.532754e-21 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000165782 E001 2.258113 0.0620601140 8.698092e-01 9.202727e-01 14 20457681 20457857 177 - 0.498 0.470 -0.137
ENSG00000165782 E002 611.272490 0.0010173036 4.796594e-08 5.196137e-07 14 20457858 20458346 489 - 2.616 2.740 0.412
ENSG00000165782 E003 290.737427 0.0001873225 2.896609e-05 1.729721e-04 14 20458347 20458385 39 - 2.305 2.414 0.362
ENSG00000165782 E004 669.787092 0.0010497821 4.621759e-03 1.487965e-02 14 20458386 20458588 203 - 2.703 2.768 0.215
ENSG00000165782 E005 320.368668 0.0005025295 8.432121e-01 9.023504e-01 14 20458589 20458616 28 - 2.432 2.432 0.001
ENSG00000165782 E006 442.387093 0.0018834422 9.734435e-01 9.874066e-01 14 20458617 20458702 86 - 2.570 2.575 0.019
ENSG00000165782 E007 56.196849 0.0004644045 1.343387e-36 3.693768e-34 14 20458703 20459205 503 - 2.051 1.461 -1.999
ENSG00000165782 E008 395.595686 0.0001992677 3.146593e-01 4.573906e-01 14 20459206 20459296 91 - 2.505 2.530 0.084
ENSG00000165782 E009 294.901395 0.0011926001 1.668114e-01 2.840290e-01 14 20459388 20459440 53 - 2.362 2.406 0.148
ENSG00000165782 E010 14.835885 0.0011664302 1.514812e-12 3.603422e-11 14 20459441 20459627 187 - 1.506 0.899 -2.167
ENSG00000165782 E011 407.489384 0.0003887686 7.875665e-01 8.639257e-01 14 20459628 20459733 106 - 2.528 2.538 0.034
ENSG00000165782 E012 35.755119 0.0005790239 4.629379e-29 7.188705e-27 14 20459734 20460191 458 - 1.881 1.231 -2.227
ENSG00000165782 E013 381.060068 0.0001998142 1.659002e-01 2.828601e-01 14 20460192 20460260 69 - 2.525 2.501 -0.082
ENSG00000165782 E014 287.251251 0.0001966013 7.551595e-01 8.405762e-01 14 20460261 20460298 38 - 2.374 2.386 0.039
ENSG00000165782 E015 46.553406 0.0052344378 4.344037e-33 9.134905e-31 14 20460299 20460654 356 - 2.028 1.293 -2.501
ENSG00000165782 E016 442.974419 0.0006662473 5.037794e-01 6.397178e-01 14 20460655 20460845 191 - 2.578 2.569 -0.032
ENSG00000165782 E017 19.684447 0.0009842992 2.013428e-11 3.988461e-10 14 20460846 20461162 317 - 1.573 1.060 -1.798
ENSG00000165782 E018 65.453696 0.0161667190 3.329009e-01 4.765688e-01 14 20461163 20461183 21 - 1.687 1.768 0.276
ENSG00000165782 E019 223.879259 0.0063228535 8.602936e-01 9.138675e-01 14 20461184 20461465 282 - 2.264 2.280 0.055