ENSG00000165688

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000371717 ENSG00000165688 HEK293_OSMI2_2hA HEK293_TMG_2hB PMPCA protein_coding protein_coding 180.5461 245.6071 138.9414 10.5009 2.492443 -0.8218304 130.65203 205.94727 82.86407 6.391918 1.898639 -1.3133525 0.7036875 0.8399667 0.5964000 -0.2435667 4.918305e-06 5.125233e-12 FALSE TRUE
ENST00000619192 ENSG00000165688 HEK293_OSMI2_2hA HEK293_TMG_2hB PMPCA protein_coding retained_intron 180.5461 245.6071 138.9414 10.5009 2.492443 -0.8218304 40.67071 33.07273 46.20271 7.080979 1.706708 0.4822113 0.2402708 0.1330667 0.3323333 0.1992667 3.806360e-04 5.125233e-12 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000165688 E001 0.000000       9 136408327 136408351 25 +      
ENSG00000165688 E002 2.884886 8.306757e-03 5.930169e-01 7.154701e-01 9 136409459 136410640 1182 + 0.603 0.522 -0.369
ENSG00000165688 E003 2.001267 9.300475e-03 7.556819e-01 8.409546e-01 9 136410641 136410643 3 + 0.478 0.430 -0.244
ENSG00000165688 E004 24.279937 7.799302e-04 5.954431e-02 1.258408e-01 9 136410644 136410657 14 + 1.440 1.311 -0.448
ENSG00000165688 E005 31.672297 6.642851e-04 1.151412e-01 2.130545e-01 9 136410658 136410659 2 + 1.526 1.432 -0.323
ENSG00000165688 E006 32.736577 6.436580e-04 4.654099e-02 1.030162e-01 9 136410660 136410660 1 + 1.557 1.438 -0.407
ENSG00000165688 E007 200.484622 7.803200e-04 1.536088e-14 4.930654e-13 9 136410661 136410673 13 + 2.392 2.179 -0.713
ENSG00000165688 E008 442.011932 3.122197e-03 3.789561e-06 2.772538e-05 9 136410674 136410701 28 + 2.687 2.547 -0.464
ENSG00000165688 E009 467.675705 3.011660e-03 6.408509e-06 4.452208e-05 9 136410702 136410705 4 + 2.707 2.574 -0.443
ENSG00000165688 E010 514.414439 2.613237e-03 3.376156e-07 3.091211e-06 9 136410706 136410714 9 + 2.753 2.612 -0.469
ENSG00000165688 E011 649.615968 2.852986e-03 4.710838e-06 3.373352e-05 9 136410715 136410739 25 + 2.844 2.719 -0.416
ENSG00000165688 E012 1.213605 1.086478e-02 8.254621e-03 2.442852e-02 9 136411118 136411405 288 + 0.602 0.153 -2.829
ENSG00000165688 E013 1499.360120 1.576166e-03 4.328562e-06 3.123698e-05 9 136411997 136412171 175 + 3.179 3.095 -0.281
ENSG00000165688 E014 917.006437 2.419656e-04 3.063272e-06 2.287276e-05 9 136412172 136412199 28 + 2.946 2.889 -0.189
ENSG00000165688 E015 2.430413 2.540706e-01 6.488077e-01 7.602577e-01 9 136412200 136412489 290 + 0.398 0.508 0.566
ENSG00000165688 E016 1125.946925 6.271569e-04 4.208477e-04 1.854320e-03 9 136412490 136412569 80 + 3.028 2.981 -0.156
ENSG00000165688 E017 2.281017 6.287793e-03 2.827908e-01 4.228358e-01 9 136412570 136412606 37 + 0.603 0.430 -0.829
ENSG00000165688 E018 1095.944173 1.004195e-03 2.639288e-02 6.473277e-02 9 136412810 136412892 83 + 3.005 2.974 -0.104
ENSG00000165688 E019 3.504288 4.809562e-03 4.167560e-03 1.361309e-02 9 136412893 136412965 73 + 0.876 0.463 -1.774
ENSG00000165688 E020 504.757777 1.269390e-03 7.805390e-02 1.563463e-01 9 136414553 136414554 2 + 2.669 2.637 -0.107
ENSG00000165688 E021 1063.926098 9.667760e-04 5.755320e-01 7.011215e-01 9 136414555 136414647 93 + 2.969 2.970 0.001
ENSG00000165688 E022 6.605800 1.197470e-01 1.436967e-01 2.530433e-01 9 136414648 136414675 28 + 1.044 0.720 -1.248
ENSG00000165688 E023 9.597614 2.090310e-03 8.143772e-03 2.414775e-02 9 136416067 136416290 224 + 1.162 0.890 -0.999
ENSG00000165688 E024 1261.504704 8.200908e-05 6.879859e-02 1.413816e-01 9 136416291 136416391 101 + 3.051 3.041 -0.033
ENSG00000165688 E025 75.409590 3.600437e-04 4.124804e-45 1.934237e-42 9 136416392 136416950 559 + 2.165 1.601 -1.900
ENSG00000165688 E026 907.527159 2.050079e-04 1.154555e-01 2.135108e-01 9 136416951 136416999 49 + 2.910 2.898 -0.040
ENSG00000165688 E027 1545.169614 9.571305e-04 9.033062e-01 9.424733e-01 9 136417000 136417193 194 + 3.126 3.134 0.027
ENSG00000165688 E028 654.610478 9.408484e-04 3.027716e-01 4.446876e-01 9 136417194 136417214 21 + 2.736 2.769 0.110
ENSG00000165688 E029 506.960487 2.855626e-03 2.199702e-01 3.503791e-01 9 136418017 136418020 4 + 2.612 2.661 0.164
ENSG00000165688 E030 990.124198 2.410877e-04 2.688965e-05 1.617914e-04 9 136418021 136418109 89 + 2.885 2.957 0.241
ENSG00000165688 E031 496.398213 1.799573e-04 5.997433e-04 2.532138e-03 9 136418555 136418557 3 + 2.582 2.659 0.255
ENSG00000165688 E032 1193.072582 4.945956e-04 8.284704e-04 3.361056e-03 9 136418558 136418673 116 + 2.973 3.036 0.210
ENSG00000165688 E033 1237.050669 8.251490e-04 5.997171e-02 1.265591e-01 9 136418828 136418918 91 + 3.003 3.047 0.148
ENSG00000165688 E034 1014.904660 1.481130e-04 1.250732e-04 6.370109e-04 9 136419044 136419106 63 + 2.902 2.966 0.211
ENSG00000165688 E035 20.960401 1.189542e-03 9.547442e-02 1.835924e-01 9 136419107 136420933 1827 + 1.372 1.248 -0.431
ENSG00000165688 E036 1469.857948 7.027530e-04 1.829089e-10 3.084249e-09 9 136421832 136421976 145 + 3.023 3.138 0.382
ENSG00000165688 E037 58.459280 4.182941e-04 2.340199e-13 6.317236e-12 9 136421977 136422788 812 + 1.938 1.603 -1.130
ENSG00000165688 E038 30.759579 8.151668e-03 1.366932e-03 5.199293e-03 9 136422789 136423094 306 + 1.608 1.370 -0.817
ENSG00000165688 E039 2961.081888 1.919182e-03 9.112739e-18 4.505170e-16 9 136423095 136423761 667 + 3.266 3.456 0.634