ENSG00000165675

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000338144 ENSG00000165675 HEK293_OSMI2_2hA HEK293_TMG_2hB ENOX2 protein_coding protein_coding 8.668819 5.408798 13.14342 0.1276241 0.2004585 1.279393 0.7314626 0.2009797 1.314799 0.1415174 0.1767418 2.6505977 0.07877500 0.03606667 0.09973333 0.06366667 3.079415e-01 1.757025e-16 FALSE TRUE
ENST00000370927 ENSG00000165675 HEK293_OSMI2_2hA HEK293_TMG_2hB ENOX2 protein_coding protein_coding 8.668819 5.408798 13.14342 0.1276241 0.2004585 1.279393 0.1972960 0.4272731 0.240550 0.4272731 0.2405500 -0.8034360 0.02351250 0.08043333 0.01880000 -0.06163333 9.036121e-01 1.757025e-16 FALSE TRUE
ENST00000370935 ENSG00000165675 HEK293_OSMI2_2hA HEK293_TMG_2hB ENOX2 protein_coding protein_coding 8.668819 5.408798 13.14342 0.1276241 0.2004585 1.279393 1.5590043 0.4105669 1.937306 0.1499434 0.2362872 2.2110724 0.17447917 0.07556667 0.14800000 0.07243333 3.102922e-01 1.757025e-16 FALSE TRUE
ENST00000394363 ENSG00000165675 HEK293_OSMI2_2hA HEK293_TMG_2hB ENOX2 protein_coding protein_coding 8.668819 5.408798 13.14342 0.1276241 0.2004585 1.279393 0.4458067 0.9850889 0.000000 0.1788877 0.0000000 -6.6367536 0.07832083 0.18326667 0.00000000 -0.18326667 1.757025e-16 1.757025e-16 FALSE TRUE
ENST00000686943 ENSG00000165675 HEK293_OSMI2_2hA HEK293_TMG_2hB ENOX2 protein_coding protein_coding 8.668819 5.408798 13.14342 0.1276241 0.2004585 1.279393 3.3068145 2.7370378 4.254467 0.3388480 0.5409902 0.6344887 0.40316667 0.50400000 0.32273333 -0.18126667 9.540860e-02 1.757025e-16 FALSE TRUE
MSTRG.34878.6 ENSG00000165675 HEK293_OSMI2_2hA HEK293_TMG_2hB ENOX2 protein_coding   8.668819 5.408798 13.14342 0.1276241 0.2004585 1.279393 2.3575745 0.6478516 5.396293 0.1999681 0.2523629 3.0388055 0.23232500 0.12056667 0.41066667 0.29010000 1.703475e-04 1.757025e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000165675 E001 35.532890 0.0022400121 1.172909e-07 1.176332e-06 X 130622325 130623368 1044 - 1.390 1.734 1.175
ENSG00000165675 E002 2.879689 0.0057473032 4.410162e-02 9.857032e-02 X 130623369 130623380 12 - 0.418 0.747 1.506
ENSG00000165675 E003 22.789640 0.0008533714 1.390360e-01 2.467591e-01 X 130623381 130623913 533 - 1.314 1.441 0.439
ENSG00000165675 E004 225.455892 0.0048511967 8.050824e-09 1.009601e-07 X 130623914 130624976 1063 - 2.241 2.473 0.772
ENSG00000165675 E005 46.823813 0.0005308314 1.305133e-02 3.603176e-02 X 130624977 130625049 73 - 1.605 1.752 0.501
ENSG00000165675 E006 149.621020 0.0002288780 8.720697e-02 1.709056e-01 X 130625050 130625445 396 - 2.138 2.207 0.231
ENSG00000165675 E007 68.390259 0.0022424619 8.765040e-01 9.247407e-01 X 130627958 130628043 86 - 1.817 1.844 0.092
ENSG00000165675 E008 71.539673 0.0005207485 8.681428e-01 9.191954e-01 X 130631468 130631576 109 - 1.842 1.855 0.044
ENSG00000165675 E009 75.306418 0.0003214891 7.444773e-01 8.328058e-01 X 130634984 130635091 108 - 1.856 1.890 0.113
ENSG00000165675 E010 93.897475 0.0003373685 4.346150e-01 5.769358e-01 X 130637229 130637404 176 - 1.966 1.957 -0.030
ENSG00000165675 E011 25.002191 0.0008660760 7.152426e-01 8.112017e-01 X 130637405 130637410 6 - 1.402 1.396 -0.022
ENSG00000165675 E012 65.559709 0.0048333113 7.719381e-01 8.528137e-01 X 130656581 130656695 115 - 1.808 1.810 0.007
ENSG00000165675 E013 61.546507 0.0008645175 4.063998e-01 5.500491e-01 X 130665643 130665749 107 - 1.792 1.773 -0.065
ENSG00000165675 E014 85.267466 0.0003497608 1.416170e-02 3.859226e-02 X 130667530 130667742 213 - 1.949 1.872 -0.260
ENSG00000165675 E015 89.787482 0.0004213265 2.759244e-05 1.655415e-04 X 130669965 130670198 234 - 1.993 1.847 -0.491
ENSG00000165675 E016 56.601131 0.0004222841 2.653658e-04 1.238733e-03 X 130679542 130679645 104 - 1.802 1.640 -0.546
ENSG00000165675 E017 60.077972 0.0004125316 8.220867e-04 3.338303e-03 X 130679646 130679748 103 - 1.820 1.679 -0.476
ENSG00000165675 E018 68.315885 0.0009221708 1.382469e-02 3.782945e-02 X 130688863 130689018 156 - 1.862 1.769 -0.313
ENSG00000165675 E019 58.670892 0.0004096501 2.675692e-02 6.548697e-02 X 130703120 130703254 135 - 1.794 1.708 -0.291
ENSG00000165675 E020 6.531207 0.0025988719 1.123623e-01 2.089901e-01 X 130709243 130709331 89 - 0.935 0.747 -0.732
ENSG00000165675 E021 43.626509 0.0005430615 2.215028e-02 5.598880e-02 X 130783547 130783690 144 - 1.678 1.571 -0.364
ENSG00000165675 E022 2.050182 0.2041829812 6.434588e-01 7.560054e-01 X 130809171 130809261 91 - 0.417 0.529 0.566
ENSG00000165675 E023 30.628654 0.0007381722 7.107527e-03 2.150430e-02 X 130901684 130901731 48 - 1.540 1.379 -0.555
ENSG00000165675 E024 39.914036 0.0007089678 1.153963e-03 4.484568e-03 X 130903049 130903268 220 - 1.656 1.482 -0.594