ENSG00000165660

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000298492 ENSG00000165660 HEK293_OSMI2_2hA HEK293_TMG_2hB ABRAXAS2 protein_coding protein_coding 15.22145 6.155082 25.34188 0.3327952 0.7186984 2.039901 10.8247482 5.21426126 16.878291 0.27742410 0.8339913 1.692724 0.78610417 0.848233333 0.66593333 -0.18230000 2.106834e-03 3.553877e-06 FALSE TRUE
MSTRG.4777.1 ENSG00000165660 HEK293_OSMI2_2hA HEK293_TMG_2hB ABRAXAS2 protein_coding   15.22145 6.155082 25.34188 0.3327952 0.7186984 2.039901 0.5940513 0.03606877 2.571298 0.02042625 0.5782553 5.808164 0.02390833 0.005566667 0.10056667 0.09500000 3.553877e-06 3.553877e-06 FALSE TRUE
MSTRG.4777.4 ENSG00000165660 HEK293_OSMI2_2hA HEK293_TMG_2hB ABRAXAS2 protein_coding   15.22145 6.155082 25.34188 0.3327952 0.7186984 2.039901 1.8815619 0.60534628 3.380217 0.33567444 0.3503685 2.461907 0.09564167 0.099633333 0.13366667 0.03403333 7.654806e-01 3.553877e-06 FALSE TRUE
MSTRG.4777.5 ENSG00000165660 HEK293_OSMI2_2hA HEK293_TMG_2hB ABRAXAS2 protein_coding   15.22145 6.155082 25.34188 0.3327952 0.7186984 2.039901 0.8931085 0.04609097 1.634878 0.02849523 0.4513570 4.874068 0.03599167 0.007133333 0.06533333 0.05820000 1.261665e-02 3.553877e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000165660 E001 0.2955422 0.0295414772 3.455600e-01   10 124801757 124801762 6 + 0.066 0.217 1.982
ENSG00000165660 E002 0.8941153 0.0567936998 5.336837e-01 6.658415e-01 10 124801763 124801798 36 + 0.219 0.359 0.977
ENSG00000165660 E003 0.8941153 0.0567936998 5.336837e-01 6.658415e-01 10 124801799 124801803 5 + 0.219 0.359 0.977
ENSG00000165660 E004 0.8941153 0.0567936998 5.336837e-01 6.658415e-01 10 124801804 124801809 6 + 0.219 0.359 0.977
ENSG00000165660 E005 10.7542408 0.0158336971 1.931938e-02 5.002506e-02 10 124801810 124801818 9 + 1.059 0.744 -1.201
ENSG00000165660 E006 66.9969928 0.0004695503 2.994968e-03 1.024924e-02 10 124801819 124801901 83 + 1.785 1.660 -0.424
ENSG00000165660 E007 58.5041208 0.0004380697 1.841859e-03 6.732681e-03 10 124806831 124806834 4 + 1.732 1.586 -0.495
ENSG00000165660 E008 98.6071409 0.0003094664 9.305473e-05 4.893801e-04 10 124806835 124806921 87 + 1.953 1.814 -0.468
ENSG00000165660 E009 72.0957850 0.0003980485 4.382208e-02 9.806123e-02 10 124816576 124816612 37 + 1.806 1.739 -0.226
ENSG00000165660 E010 82.8347243 0.0006145567 3.252250e-01 4.686544e-01 10 124819384 124819450 67 + 1.851 1.839 -0.039
ENSG00000165660 E011 49.0502763 0.0070353300 8.925700e-01 9.353721e-01 10 124826595 124826598 4 + 1.615 1.656 0.140
ENSG00000165660 E012 126.0130556 0.0002567566 1.557429e-02 4.178768e-02 10 124826599 124826785 187 + 2.043 1.986 -0.189
ENSG00000165660 E013 112.2799038 0.0002877906 4.566574e-03 1.472802e-02 10 124828756 124828875 120 + 2.000 1.921 -0.268
ENSG00000165660 E014 111.8355666 0.0003218136 5.949266e-03 1.847445e-02 10 124829393 124829477 85 + 1.997 1.921 -0.258
ENSG00000165660 E015 58.6996184 0.0004351532 2.562993e-02 6.318498e-02 10 124831349 124831352 4 + 1.725 1.635 -0.308
ENSG00000165660 E016 115.6413495 0.0002454649 7.261741e-03 2.190664e-02 10 124831353 124831463 111 + 2.011 1.940 -0.239
ENSG00000165660 E017 190.5916487 0.0009102459 2.448108e-01 3.798107e-01 10 124834502 124834828 327 + 2.212 2.210 -0.005
ENSG00000165660 E018 316.5413258 0.0012618743 4.328375e-02 9.708020e-02 10 124834829 124835686 858 + 2.409 2.496 0.290
ENSG00000165660 E019 330.6082025 0.0036441927 7.502391e-15 2.518259e-13 10 124835687 124836667 981 + 2.369 2.641 0.909