ENSG00000165644

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372538 ENSG00000165644 HEK293_OSMI2_2hA HEK293_TMG_2hB COMTD1 protein_coding protein_coding 78.02624 144.9403 43.61401 12.77015 0.3767896 -1.732364 1.219988 1.597692 3.398048 1.5976923 0.09292322 1.083955 0.02752917 0.01333333 0.07793333 0.06460000 7.315173e-02 1.899856e-08 FALSE  
ENST00000460899 ENSG00000165644 HEK293_OSMI2_2hA HEK293_TMG_2hB COMTD1 protein_coding processed_transcript 78.02624 144.9403 43.61401 12.77015 0.3767896 -1.732364 10.966833 15.911175 5.587227 2.2186255 0.53994196 -1.508163 0.16384583 0.10953333 0.12790000 0.01836667 6.579894e-01 1.899856e-08 TRUE  
ENST00000469299 ENSG00000165644 HEK293_OSMI2_2hA HEK293_TMG_2hB COMTD1 protein_coding protein_coding 78.02624 144.9403 43.61401 12.77015 0.3767896 -1.732364 5.474758 11.152926 2.449165 1.9809838 1.22516271 -2.182475 0.05250833 0.07596667 0.05660000 -0.01936667 8.063095e-01 1.899856e-08 FALSE  
ENST00000470947 ENSG00000165644 HEK293_OSMI2_2hA HEK293_TMG_2hB COMTD1 protein_coding processed_transcript 78.02624 144.9403 43.61401 12.77015 0.3767896 -1.732364 9.341132 21.208598 5.762313 1.0641682 0.41084745 -1.878108 0.10707917 0.14976667 0.13203333 -0.01773333 8.059517e-01 1.899856e-08 FALSE  
ENST00000490521 ENSG00000165644 HEK293_OSMI2_2hA HEK293_TMG_2hB COMTD1 protein_coding processed_transcript 78.02624 144.9403 43.61401 12.77015 0.3767896 -1.732364 12.215850 20.047305 7.290370 2.8242694 0.19706056 -1.458086 0.17470417 0.13710000 0.16716667 0.03006667 2.111963e-01 1.899856e-08 FALSE  
ENST00000494596 ENSG00000165644 HEK293_OSMI2_2hA HEK293_TMG_2hB COMTD1 protein_coding processed_transcript 78.02624 144.9403 43.61401 12.77015 0.3767896 -1.732364 7.528881 18.497884 1.926208 1.5545707 0.28194496 -3.256834 0.07725000 0.12776667 0.04426667 -0.08350000 1.899856e-08 1.899856e-08 FALSE  
MSTRG.4229.1 ENSG00000165644 HEK293_OSMI2_2hA HEK293_TMG_2hB COMTD1 protein_coding   78.02624 144.9403 43.61401 12.77015 0.3767896 -1.732364 5.752859 10.665206 3.841040 2.1712222 0.44681550 -1.470944 0.07333333 0.07200000 0.08790000 0.01590000 6.526088e-01 1.899856e-08 FALSE  
MSTRG.4229.11 ENSG00000165644 HEK293_OSMI2_2hA HEK293_TMG_2hB COMTD1 protein_coding   78.02624 144.9403 43.61401 12.77015 0.3767896 -1.732364 16.393855 32.358584 8.435719 4.5713588 0.46573370 -1.938302 0.18801667 0.22103333 0.19323333 -0.02780000 5.638076e-01 1.899856e-08 FALSE  
MSTRG.4229.6 ENSG00000165644 HEK293_OSMI2_2hA HEK293_TMG_2hB COMTD1 protein_coding   78.02624 144.9403 43.61401 12.77015 0.3767896 -1.732364 5.775708 8.654990 3.110197 0.6164285 0.43569698 -1.473561 0.08506667 0.06000000 0.07136667 0.01136667 7.078057e-01 1.899856e-08 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000165644 E001 8.233899 0.0020151460 2.274646e-13 6.149031e-12 10 75233575 75233640 66 - 1.367 0.561 -3.077
ENSG00000165644 E002 7.684614 0.0178942480 1.484208e-07 1.458320e-06 10 75233641 75233661 21 - 1.266 0.604 -2.532
ENSG00000165644 E003 9.029121 0.0472459699 1.583354e-05 1.004931e-04 10 75233662 75233694 33 - 1.307 0.695 -2.288
ENSG00000165644 E004 21.562387 0.0008975936 4.768468e-15 1.644588e-13 10 75233695 75233970 276 - 1.647 1.063 -2.038
ENSG00000165644 E005 29.394717 0.0110591756 3.360799e-02 7.898343e-02 10 75233971 75233977 7 - 1.525 1.346 -0.617
ENSG00000165644 E006 65.030161 0.0035590581 5.996469e-01 7.210126e-01 10 75233978 75233983 6 - 1.742 1.713 -0.096
ENSG00000165644 E007 650.174704 0.0040561364 4.594168e-02 1.019278e-01 10 75233984 75234225 242 - 2.654 2.725 0.236
ENSG00000165644 E008 71.532988 0.0004293785 3.278225e-01 4.712959e-01 10 75234226 75234285 60 - 1.795 1.747 -0.161
ENSG00000165644 E009 112.046438 0.0014564662 9.255071e-01 9.570924e-01 10 75234286 75234425 140 - 1.940 1.947 0.023
ENSG00000165644 E010 55.543949 0.0090262544 7.919957e-01 8.669545e-01 10 75234426 75234435 10 - 1.659 1.644 -0.050
ENSG00000165644 E011 111.136868 0.0003313113 1.307358e-01 2.351800e-01 10 75234436 75234609 174 - 1.988 1.929 -0.200
ENSG00000165644 E012 858.821151 0.0002416355 5.209800e-02 1.128944e-01 10 75234610 75234743 134 - 2.802 2.834 0.107
ENSG00000165644 E013 611.315567 0.0002037341 3.804077e-01 5.246968e-01 10 75234938 75234992 55 - 2.665 2.682 0.059
ENSG00000165644 E014 85.185640 0.0053349567 3.872231e-01 5.313697e-01 10 75234993 75235059 67 - 1.861 1.818 -0.144
ENSG00000165644 E015 587.404750 0.0033621019 1.978640e-01 3.235516e-01 10 75235060 75235178 119 - 2.690 2.660 -0.100
ENSG00000165644 E016 427.208533 0.0009891127 5.352326e-01 6.671496e-01 10 75235267 75235314 48 - 2.512 2.531 0.063
ENSG00000165644 E017 470.460925 0.0001344993 1.038349e-01 1.963547e-01 10 75235315 75235372 58 - 2.539 2.573 0.113
ENSG00000165644 E018 142.659814 0.0002386132 3.840427e-01 5.282413e-01 10 75235373 75235615 243 - 2.076 2.045 -0.101
ENSG00000165644 E019 191.612517 0.0002605965 4.923498e-01 6.295334e-01 10 75235616 75235619 4 - 2.161 2.184 0.077
ENSG00000165644 E020 389.932214 0.0002434139 2.931181e-01 4.341531e-01 10 75235620 75235743 124 - 2.504 2.482 -0.072
ENSG00000165644 E021 25.174875 0.0291349811 9.638574e-02 1.849413e-01 10 75235744 75235834 91 - 1.449 1.272 -0.617
ENSG00000165644 E022 407.464128 0.0050443083 4.857178e-01 6.235477e-01 10 75235835 75236069 235 - 2.478 2.515 0.122