ENSG00000165637

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000332211 ENSG00000165637 HEK293_OSMI2_2hA HEK293_TMG_2hB VDAC2 protein_coding protein_coding 285.0758 331.8095 291.699 31.59944 10.69784 -0.185869 222.00008 292.43644 203.10618 30.648046 3.285564 -0.5258672 0.7763083 0.87966667 0.6974667 -0.1822000 2.548636e-11 2.548636e-11 FALSE TRUE
ENST00000447677 ENSG00000165637 HEK293_OSMI2_2hA HEK293_TMG_2hB VDAC2 protein_coding protein_coding 285.0758 331.8095 291.699 31.59944 10.69784 -0.185869 37.82895 18.40604 63.31262 0.877218 9.434559 1.7817579 0.1343000 0.05703333 0.2152667 0.1582333 3.496972e-07 2.548636e-11 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000165637 E001 1.2845794 1.084697e-02 6.635897e-01 7.715942e-01 10 75210012 75210131 120 + 0.400 0.326 -0.438
ENSG00000165637 E002 0.8502072 1.453661e-02 9.184234e-01 9.524497e-01 10 75210132 75210153 22 + 0.245 0.265 0.148
ENSG00000165637 E003 1.3243333 1.050123e-02 6.656498e-01 7.733015e-01 10 75210154 75210164 11 + 0.401 0.326 -0.437
ENSG00000165637 E004 5.9010900 2.169795e-02 4.218470e-01 5.649873e-01 10 75210165 75210212 48 + 0.893 0.781 -0.437
ENSG00000165637 E005 1.8339484 8.398178e-03 9.353888e-02 1.806539e-01 10 75210542 75210553 12 + 0.605 0.326 -1.439
ENSG00000165637 E006 16.4968272 1.028669e-02 2.884919e-01 4.290958e-01 10 75210554 75210644 91 + 1.291 1.191 -0.352
ENSG00000165637 E007 70.9684866 9.701601e-02 1.751924e-01 2.949297e-01 10 75210645 75210716 72 + 1.622 1.943 1.084
ENSG00000165637 E008 14.1607037 2.297693e-02 2.342254e-01 3.674290e-01 10 75210717 75210774 58 + 1.247 1.107 -0.499
ENSG00000165637 E009 17.8066507 2.625458e-02 3.823634e-01 5.265928e-01 10 75210775 75210795 21 + 1.324 1.221 -0.361
ENSG00000165637 E010 37.8516790 6.566152e-04 9.306886e-01 9.603853e-01 10 75210796 75210803 8 + 1.585 1.585 -0.002
ENSG00000165637 E011 72.8875362 3.362580e-04 2.972213e-01 4.385265e-01 10 75210804 75210812 9 + 1.885 1.845 -0.134
ENSG00000165637 E012 82.9560346 3.105636e-04 5.362201e-02 1.155902e-01 10 75210813 75210813 1 + 1.960 1.888 -0.241
ENSG00000165637 E013 335.4162266 1.212365e-02 7.877995e-02 1.575599e-01 10 75210814 75210847 34 + 2.578 2.469 -0.362
ENSG00000165637 E014 352.9978402 1.729250e-02 1.244775e-01 2.263602e-01 10 75210848 75210848 1 + 2.601 2.490 -0.369
ENSG00000165637 E015 490.8322358 2.673059e-03 4.759229e-01 6.146024e-01 10 75210849 75210855 7 + 2.695 2.671 -0.081
ENSG00000165637 E016 547.6825775 3.941494e-03 7.373877e-01 8.275871e-01 10 75210856 75210863 8 + 2.737 2.721 -0.056
ENSG00000165637 E017 923.9121161 3.423463e-03 6.503849e-02 1.351010e-01 10 75210864 75210938 75 + 2.991 2.930 -0.204
ENSG00000165637 E018 28.7064650 6.845961e-04 9.142700e-02 1.773613e-01 10 75211034 75211133 100 + 1.531 1.427 -0.358
ENSG00000165637 E019 1140.0531792 1.298642e-03 3.946411e-04 1.754025e-03 10 75211134 75211189 56 + 3.089 3.017 -0.240
ENSG00000165637 E020 0.6028395 4.529233e-01 3.852320e-01 5.294236e-01 10 75211456 75211481 26 + 0.331 0.105 -2.067
ENSG00000165637 E021 1.4509703 8.410678e-02 4.939089e-01 6.309393e-01 10 75211482 75211659 178 + 0.462 0.325 -0.766
ENSG00000165637 E022 1490.1239752 7.231332e-05 1.490837e-04 7.430924e-04 10 75212230 75212298 69 + 3.186 3.152 -0.111
ENSG00000165637 E023 1492.9305087 1.556418e-04 1.485558e-04 7.406755e-04 10 75214021 75214070 50 + 3.189 3.151 -0.125
ENSG00000165637 E024 20.7493203 9.083655e-04 9.812372e-04 3.895728e-03 10 75217888 75217932 45 + 1.463 1.222 -0.840
ENSG00000165637 E025 16.6142910 1.785499e-03 5.716055e-02 1.217400e-01 10 75217933 75217945 13 + 1.324 1.167 -0.551
ENSG00000165637 E026 23.8565262 9.250749e-04 3.070322e-02 7.333583e-02 10 75217946 75217991 46 + 1.468 1.319 -0.517
ENSG00000165637 E027 0.8480291 1.475125e-02 3.851563e-02 8.830427e-02 10 75217992 75218238 247 + 0.000 0.380 10.905
ENSG00000165637 E028 2657.5758114 4.227772e-04 4.779334e-07 4.243476e-06 10 75219063 75219215 153 + 3.448 3.392 -0.184
ENSG00000165637 E029 20.6372008 9.444388e-04 2.432810e-02 6.049120e-02 10 75219216 75219303 88 + 1.421 1.257 -0.573
ENSG00000165637 E030 1834.1684423 7.503898e-04 2.130347e-03 7.628250e-03 10 75219304 75219356 53 + 3.281 3.235 -0.153
ENSG00000165637 E031 2114.6755226 1.019435e-03 6.203441e-01 7.375411e-01 10 75220743 75220970 228 + 3.311 3.316 0.014
ENSG00000165637 E032 3.5449614 4.394755e-03 9.203882e-03 2.679526e-02 10 75220971 75221032 62 + 0.849 0.471 -1.631
ENSG00000165637 E033 1401.5222680 1.427288e-04 7.975172e-23 6.943348e-21 10 75222252 75222402 151 + 3.068 3.178 0.365
ENSG00000165637 E034 8.6849933 1.563536e-02 9.058421e-03 2.642416e-02 10 75229310 75229643 334 + 0.744 1.092 1.321
ENSG00000165637 E035 1136.5864749 8.305004e-04 1.529652e-17 7.312338e-16 10 75229644 75229701 58 + 2.948 3.098 0.497
ENSG00000165637 E036 1531.8172842 1.559215e-03 1.153156e-19 7.065391e-18 10 75230898 75231448 551 + 3.050 3.236 0.618