ENSG00000165629

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356708 ENSG00000165629 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP5F1C protein_coding protein_coding 198.1866 113.6555 289.2471 21.81262 9.769785 1.347558 125.10685 87.55943 171.62196 20.665683 3.938468 0.970819 0.6561125 0.7589333 0.5946667 -0.1642667 0.01633127 1.290343e-05 FALSE TRUE
ENST00000460820 ENSG00000165629 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP5F1C protein_coding processed_transcript 198.1866 113.6555 289.2471 21.81262 9.769785 1.347558 45.24828 11.23540 75.98271 2.265764 10.101194 2.756525 0.2027125 0.1111333 0.2611000 0.1499667 0.09174304 1.290343e-05 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000165629 E001 1.392187 0.0439128189 1.181772e-01 2.173202e-01 10 7788043 7788080 38 + 0.234 0.510 1.648
ENSG00000165629 E002 1.392187 0.0439128189 1.181772e-01 2.173202e-01 10 7788081 7788084 4 + 0.234 0.510 1.650
ENSG00000165629 E003 1.543702 0.0133547901 2.066663e-01 3.345608e-01 10 7788085 7788095 11 + 0.290 0.509 1.229
ENSG00000165629 E004 1.993982 0.0086545397 6.196109e-01 7.369655e-01 10 7788096 7788105 10 + 0.426 0.509 0.421
ENSG00000165629 E005 3.177399 0.0047536633 6.555380e-01 7.654172e-01 10 7788106 7788110 5 + 0.636 0.565 -0.317
ENSG00000165629 E006 3.772851 0.0041510420 3.088447e-01 4.511086e-01 10 7788111 7788115 5 + 0.723 0.565 -0.680
ENSG00000165629 E007 4.360815 0.0037606761 2.706319e-01 4.092624e-01 10 7788116 7788127 12 + 0.778 0.615 -0.680
ENSG00000165629 E008 8.758890 0.0060375958 7.941462e-01 8.684554e-01 10 7788128 7788146 19 + 1.002 0.975 -0.099
ENSG00000165629 E009 10.936542 0.0271572217 5.342078e-01 6.662941e-01 10 7788147 7788158 12 + 1.102 1.044 -0.212
ENSG00000165629 E010 34.070160 0.0073333440 1.166859e-01 2.152315e-01 10 7788159 7788174 16 + 1.584 1.461 -0.420
ENSG00000165629 E011 50.567050 0.0042173003 1.458393e-01 2.560048e-01 10 7788175 7788176 2 + 1.742 1.652 -0.307
ENSG00000165629 E012 55.072951 0.0034384951 9.349222e-02 1.805781e-01 10 7788177 7788178 2 + 1.781 1.685 -0.327
ENSG00000165629 E013 105.590403 0.0009397486 4.916944e-07 4.354026e-06 10 7788179 7788183 5 + 2.091 1.891 -0.672
ENSG00000165629 E014 412.324370 0.0005753596 9.481529e-12 1.983489e-10 10 7788184 7788209 26 + 2.665 2.514 -0.502
ENSG00000165629 E015 740.605707 0.0007969632 1.445875e-07 1.424201e-06 10 7788210 7788263 54 + 2.904 2.794 -0.363
ENSG00000165629 E016 758.972083 0.0005744680 4.869557e-07 4.315456e-06 10 7796121 7796155 35 + 2.910 2.815 -0.315
ENSG00000165629 E017 1.811234 0.0131013190 6.136583e-01 7.323019e-01 10 7796156 7796588 433 + 0.463 0.369 -0.507
ENSG00000165629 E018 2.742810 0.0326240133 1.735914e-01 2.928518e-01 10 7796606 7797046 441 + 0.463 0.698 1.069
ENSG00000165629 E019 1400.617792 0.0012124891 1.543276e-03 5.776103e-03 10 7797047 7797178 132 + 3.167 3.093 -0.244
ENSG00000165629 E020 1709.207466 0.0001737582 1.087917e-01 2.037553e-01 10 7798990 7799194 205 + 3.237 3.217 -0.066
ENSG00000165629 E021 13.220382 0.0257881180 6.074759e-06 4.242746e-05 10 7799195 7799550 356 + 1.302 0.658 -2.427
ENSG00000165629 E022 1219.058614 0.0002333548 2.402158e-01 3.743771e-01 10 7799772 7799915 144 + 3.078 3.089 0.036
ENSG00000165629 E023 686.555527 0.0005768855 8.080876e-01 8.780450e-01 10 7800027 7800051 25 + 2.833 2.836 0.010
ENSG00000165629 E024 904.040122 0.0006456228 2.922820e-01 4.332330e-01 10 7800052 7800091 40 + 2.947 2.961 0.047
ENSG00000165629 E025 16.719524 0.0317505646 7.292479e-08 7.605077e-07 10 7801513 7801569 57 + 1.415 0.613 -3.008
ENSG00000165629 E026 4.216813 0.0160904044 6.091109e-01 7.286577e-01 10 7802243 7802269 27 + 0.742 0.659 -0.344
ENSG00000165629 E027 553.962880 0.0006311868 1.676653e-01 2.851549e-01 10 7802270 7802273 4 + 2.731 2.756 0.083
ENSG00000165629 E028 1344.075903 0.0004024706 1.641516e-03 6.093808e-03 10 7802274 7802425 152 + 3.110 3.148 0.127
ENSG00000165629 E029 977.143923 0.0011716569 1.075087e-04 5.566482e-04 10 7802758 7802854 97 + 2.956 3.028 0.238
ENSG00000165629 E030 542.665298 0.0002236056 1.253537e-18 6.833923e-17 10 7806974 7807010 37 + 2.672 2.817 0.483
ENSG00000165629 E031 583.836789 0.0001483766 1.752380e-22 1.477450e-20 10 7807659 7807815 157 + 2.701 2.851 0.500