ENSG00000165626

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000378605 ENSG00000165626 HEK293_OSMI2_2hA HEK293_TMG_2hB BEND7 protein_coding protein_coding 6.555806 5.796206 8.831034 0.1737287 0.3882479 0.6066194 0.6944351 0.0000000 1.2402008 0.00000000 0.18877947 6.9660160 0.10360833 0.00000000 0.14080000 0.14080000 9.977395e-12 7.022566e-17 FALSE TRUE
ENST00000440282 ENSG00000165626 HEK293_OSMI2_2hA HEK293_TMG_2hB BEND7 protein_coding protein_coding 6.555806 5.796206 8.831034 0.1737287 0.3882479 0.6066194 0.9466089 0.5172024 1.1859162 0.05833263 0.04314003 1.1816874 0.14480417 0.08933333 0.13480000 0.04546667 2.361007e-01 7.022566e-17 FALSE FALSE
ENST00000466271 ENSG00000165626 HEK293_OSMI2_2hA HEK293_TMG_2hB BEND7 protein_coding protein_coding 6.555806 5.796206 8.831034 0.1737287 0.3882479 0.6066194 0.2361831 0.8326722 0.0000000 0.08888920 0.00000000 -6.3968995 0.04047917 0.14393333 0.00000000 -0.14393333 7.022566e-17 7.022566e-17 FALSE TRUE
ENST00000480703 ENSG00000165626 HEK293_OSMI2_2hA HEK293_TMG_2hB BEND7 protein_coding protein_coding 6.555806 5.796206 8.831034 0.1737287 0.3882479 0.6066194 0.9079433 1.6128417 0.5463187 0.27097933 0.54631875 -1.5445387 0.14509167 0.28146667 0.05823333 -0.22323333 1.002019e-01 7.022566e-17 FALSE TRUE
ENST00000683141 ENSG00000165626 HEK293_OSMI2_2hA HEK293_TMG_2hB BEND7 protein_coding protein_coding 6.555806 5.796206 8.831034 0.1737287 0.3882479 0.6066194 0.8094480 0.5913629 0.9322687 0.14055123 0.19741836 0.6479027 0.12479583 0.10113333 0.10793333 0.00680000 9.745517e-01 7.022566e-17 FALSE TRUE
ENST00000689161 ENSG00000165626 HEK293_OSMI2_2hA HEK293_TMG_2hB BEND7 protein_coding protein_coding 6.555806 5.796206 8.831034 0.1737287 0.3882479 0.6066194 0.3059227 0.5243404 0.2901807 0.15397295 0.29018067 -0.8319280 0.04550417 0.08946667 0.03213333 -0.05733333 2.495072e-01 7.022566e-17 FALSE TRUE
ENST00000689491 ENSG00000165626 HEK293_OSMI2_2hA HEK293_TMG_2hB BEND7 protein_coding retained_intron 6.555806 5.796206 8.831034 0.1737287 0.3882479 0.6066194 0.1245297 0.3915452 0.0000000 0.39154515 0.00000000 -5.3274903 0.02174167 0.06400000 0.00000000 -0.06400000 7.439018e-01 7.022566e-17 FALSE TRUE
MSTRG.3561.19 ENSG00000165626 HEK293_OSMI2_2hA HEK293_TMG_2hB BEND7 protein_coding   6.555806 5.796206 8.831034 0.1737287 0.3882479 0.6066194 0.1173147 0.0000000 0.4946166 0.00000000 0.49461660 5.6571158 0.01269167 0.00000000 0.05273333 0.05273333 8.921347e-01 7.022566e-17 FALSE TRUE
MSTRG.3561.21 ENSG00000165626 HEK293_OSMI2_2hA HEK293_TMG_2hB BEND7 protein_coding   6.555806 5.796206 8.831034 0.1737287 0.3882479 0.6066194 0.1187713 0.0000000 0.6104012 0.00000000 0.43448323 5.9551296 0.01431250 0.00000000 0.06923333 0.06923333 2.863220e-01 7.022566e-17 FALSE TRUE
MSTRG.3561.3 ENSG00000165626 HEK293_OSMI2_2hA HEK293_TMG_2hB BEND7 protein_coding   6.555806 5.796206 8.831034 0.1737287 0.3882479 0.6066194 0.5433080 0.0000000 1.2797841 0.00000000 0.65079753 7.0109857 0.08322500 0.00000000 0.14913333 0.14913333 2.323118e-01 7.022566e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000165626 E001 0.0000000       10 13438484 13438636 153 -      
ENSG00000165626 E002 1.9144847 0.0073783869 7.334478e-02 0.1488756705 10 13438637 13439497 861 - 0.280 0.581 1.638
ENSG00000165626 E003 0.3289534 0.0290780798 9.020527e-01   10 13441087 13441087 1 - 0.114 0.131 0.223
ENSG00000165626 E004 1.2501346 0.0108592605 2.937993e-02 0.0707360901 10 13441088 13441109 22 - 0.114 0.493 2.808
ENSG00000165626 E005 3.9059860 0.0223618387 8.138538e-03 0.0241358387 10 13441110 13441151 42 - 0.448 0.862 1.796
ENSG00000165626 E006 5.4506306 0.0165898923 3.862256e-04 0.0017215563 10 13441152 13441156 5 - 0.493 1.003 2.106
ENSG00000165626 E007 17.7539896 0.0110479082 3.122901e-05 0.0001850619 10 13441157 13441354 198 - 1.039 1.433 1.394
ENSG00000165626 E008 16.4040150 0.0012399998 5.046685e-03 0.0160588447 10 13441355 13441402 48 - 1.116 1.344 0.806
ENSG00000165626 E009 40.0471770 0.0005722055 3.833969e-02 0.0879871603 10 13441403 13441468 66 - 1.559 1.666 0.362
ENSG00000165626 E010 35.8990694 0.0005777502 3.632969e-01 0.5077200349 10 13441469 13441474 6 - 1.545 1.591 0.156
ENSG00000165626 E011 35.7476678 0.0006126381 3.308025e-01 0.4743739273 10 13441475 13441477 3 - 1.541 1.591 0.169
ENSG00000165626 E012 53.3655356 0.0004313381 2.498650e-02 0.0618458233 10 13441478 13441551 74 - 1.681 1.781 0.337
ENSG00000165626 E013 32.4843296 0.0006433805 9.442225e-02 0.1820106975 10 13441552 13441559 8 - 1.476 1.570 0.323
ENSG00000165626 E014 43.8005784 0.0006710563 1.216431e-02 0.0339250150 10 13441560 13441602 43 - 1.587 1.712 0.425
ENSG00000165626 E015 54.6489345 0.0004774705 6.684901e-04 0.0027831888 10 13441603 13441668 66 - 1.656 1.810 0.523
ENSG00000165626 E016 38.5946140 0.0005929364 8.151525e-03 0.0241660320 10 13441669 13441699 31 - 1.518 1.659 0.483
ENSG00000165626 E017 39.4373733 0.0005698549 8.154337e-03 0.0241732337 10 13441700 13441750 51 - 1.529 1.669 0.476
ENSG00000165626 E018 167.3318293 0.0002252244 2.028349e-02 0.0520775440 10 13441751 13443052 1302 - 2.198 2.252 0.180
ENSG00000165626 E019 17.6747507 0.0010486459 1.106266e-01 0.2064531165 10 13443053 13443095 43 - 1.332 1.198 -0.473
ENSG00000165626 E020 49.9240951 0.0225091781 5.616854e-02 0.1199992411 10 13443096 13443403 308 - 1.776 1.614 -0.552
ENSG00000165626 E021 8.7630895 0.0020297912 2.009715e-01 0.3273878665 10 13443404 13443456 53 - 1.051 0.905 -0.543
ENSG00000165626 E022 19.2758120 0.0009834564 1.208281e-01 0.2211301878 10 13443457 13443704 248 - 1.362 1.235 -0.444
ENSG00000165626 E023 31.8895855 0.0006867421 2.660858e-05 0.0001602580 10 13443705 13445289 1585 - 1.632 1.364 -0.920
ENSG00000165626 E024 3.2515842 0.0048436540 1.116138e-02 0.0315524931 10 13445290 13445315 26 - 0.787 0.381 -1.865
ENSG00000165626 E025 10.9591188 0.0132690067 2.857401e-02 0.0691569463 10 13445316 13445519 204 - 1.190 0.940 -0.908
ENSG00000165626 E026 5.5203086 0.0166031446 8.074430e-02 0.1607090103 10 13445520 13445560 41 - 0.931 0.686 -0.970
ENSG00000165626 E027 23.4889416 0.0008353470 6.859938e-03 0.0208606015 10 13445561 13446443 883 - 1.476 1.277 -0.690
ENSG00000165626 E028 4.1298179 0.0044444977 3.616282e-02 0.0839030650 10 13446444 13446484 41 - 0.847 0.539 -1.293
ENSG00000165626 E029 8.3805062 0.0314719976 1.580100e-01 0.2724837533 10 13446485 13446541 57 - 1.063 0.864 -0.744
ENSG00000165626 E030 22.3962379 0.0100725022 2.440548e-03 0.0085832856 10 13446542 13447265 724 - 1.485 1.217 -0.934
ENSG00000165626 E031 35.5693194 0.0052328164 1.812873e-01 0.3028548279 10 13447266 13447316 51 - 1.604 1.510 -0.321
ENSG00000165626 E032 9.6040818 0.0144836421 9.240207e-01 0.9561450206 10 13447317 13447319 3 - 1.015 1.022 0.028
ENSG00000165626 E033 51.9417824 0.0004498376 1.321487e-01 0.2370912536 10 13452539 13452658 120 - 1.761 1.682 -0.266
ENSG00000165626 E034 0.3686942 0.0308358726 9.010876e-01 0.9409202529 10 13459505 13460083 579 - 0.114 0.131 0.225
ENSG00000165626 E035 69.9520610 0.0057676841 7.016965e-02 0.1436444321 10 13480899 13481124 226 - 1.901 1.794 -0.359
ENSG00000165626 E036 63.3444815 0.0056477360 6.254269e-01 0.7415570709 10 13492611 13492876 266 - 1.822 1.786 -0.120
ENSG00000165626 E037 38.1374755 0.0006124200 5.160852e-02 0.1120145703 10 13496766 13496888 123 - 1.647 1.532 -0.393
ENSG00000165626 E038 0.2944980 0.3761857438 3.455068e-01   10 13496889 13496954 66 - 0.205 0.000 -10.428
ENSG00000165626 E039 16.5137714 0.0013052111 8.973273e-01 0.9384298997 10 13499739 13499777 39 - 1.259 1.243 -0.057
ENSG00000165626 E040 68.4489168 0.0004770781 6.877215e-01 0.7899998137 10 13499778 13500080 303 - 1.856 1.833 -0.078
ENSG00000165626 E041 0.3299976 0.0274424043 1.585964e-01   10 13500510 13500679 170 - 0.000 0.231 10.974
ENSG00000165626 E042 0.0000000       10 13502861 13502976 116 -      
ENSG00000165626 E043 0.0000000       10 13517660 13517742 83 -      
ENSG00000165626 E044 0.2214452 0.0395961635 4.147660e-01   10 13518553 13518658 106 - 0.000 0.131 9.909
ENSG00000165626 E045 28.8848918 0.0010057709 3.804531e-01 0.5247323460 10 13526138 13526221 84 - 1.506 1.443 -0.216
ENSG00000165626 E046 24.7656456 0.0008110733 4.238121e-04 0.0018657756 10 13528473 13529014 542 - 1.522 1.269 -0.876